Ma’Ayeh M, Rood KM, Kniss D, Costantine MM. Novel interventions for the prevention of preeclampsia. Curr Hypertens Rep. 2020;22:17.

Article  PubMed  PubMed Central  Google Scholar 

Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124:1094–112.

Article  CAS  PubMed  Google Scholar 

MacDonald TM, Walker SP, Hannan NJ, Tong S, Kaitu’U-Lino TJ. Clinical tools and biomarkers to predict preeclampsia. EBioMedicine. 2022;75:103780.

Article  CAS  PubMed  Google Scholar 

Yang Y, Le Ray I, Zhu J, Zhang J, Hua J, Reilly M. Preeclampsia prevalence, risk factors, and pregnancy outcomes in Sweden and China. JAMA Netw Open. 2021;4:e218401.

Article  PubMed  PubMed Central  Google Scholar 

Phipps EA, Thadhani R, Benzing T, Karumanchi SA. Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol. 2019;15:275–89.

Article  PubMed  PubMed Central  Google Scholar 

Jia X, Yang S, Wang X, Ruan J, Huang W. HOXB3 promotes trophoblast cell proliferation, invasion, and migration to alleviate preeclampsia via mediating the Notch/Wnt/beta-catenin pathway. Eur J Pharmacol. 2023;960:176015.

Article  CAS  PubMed  Google Scholar 

Shen R, Ruan H, Lin S, Liu B, Song H, Li L, et al. Lysine succinylation, the metabolic bridge between cancer and immunity. Genes Dis. 2023;10:2470–8.

Article  CAS  PubMed  Google Scholar 

Walter M, Chen IP, Vallejo-Gracia A, Kim IJ, Bielska O, Lam VL, et al. SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. PLoS Pathog. 2022;18:e1010811.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao J, Wang D, Wang D, Wu Q, Shang Q, Gao C, et al. SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis. Exp Mol Med. 2023;55:253–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Y, Qi Y, Wang L, Zheng Z, Zhang Y, Zheng J. SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis. Free Radic Biol Med. 2019;134:458–67.

Article  CAS  PubMed  Google Scholar 

Schworer S, Becker F, Feller C, Baig AH, Kober U, Henze H, et al. Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature. 2016;540:428–32.

Article  PubMed  Google Scholar 

Zhu L, Yu S, Jiang S, Ge G, Yan Y, Zhou Y, et al. Loss of HOXB3 correlates with the development of hormone receptor negative breast cancer. PeerJ. 2020;8:e10421.

Article  PubMed  PubMed Central  Google Scholar 

Daftary GS, Taylor HS. Endocrine regulation of HOX genes. Endocr Rev. 2006;27:331–55.

Article  CAS  PubMed  Google Scholar 

Zhu S, Yang Z, Zhang Z, Zhang H, Li S, Wu T, et al. HOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer. Cell Death Dis. 2023;14:215.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong W, Peng H, Tian A, Wei Y, Li H, Tian J, et al. Expression of miRNA-1233 in placenta from patients with hypertensive disorder complicating pregnancy and its role in disease pathogenesis. Int J Clin Exp Med. 2015;8:9121–7.

PubMed  PubMed Central  Google Scholar 

Zhou J, Guo X, Sun Y, Ma L, Zhe R. Levels of serum Hoxb3 and sFlt-1 in pre-eclamptic patients and their effects on pregnancy outcomes. J Obstet Gynaecol Res. 2020;46:2010–8.

Article  CAS  PubMed  Google Scholar 

Wang H, Zhang X, Liu C, Chen S, Liu X, Fan S. TAGLN2-regulated trophoblast migration, invasion and fusion are impaired in preeclampsia. Front Cell Dev Biol. 2022;10:810633.

Article  PubMed  PubMed Central  Google Scholar 

Peng W, Tong C, Li L, Huang C, Ran Y, Chen X, et al. Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia. FASEB J. 2019;33:6327–38.

Article  CAS  PubMed  Google Scholar 

Liu B, Hu Y, Wan L, Wang L, Cheng L, Sun H, et al. Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma. Front Endocrinol (Lausanne). 2022;13:1031210.

Article  PubMed  Google Scholar 

Chen G, Chen L, Huang Y, Zhu X, Yu Y. Increased FUN14 domain containing 1 (FUNDC1) ubiquitination level inhibits mitophagy and alleviates the injury in hypoxia-induced trophoblast cells. Bioengineered. 2022;13:3620–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akcora YD, Irtegun KS, Agacayak E, Deveci E. Evaluation of protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E in the placenta of women with preeclampsia. Cell Mol Biol (Noisy-le-grand). 2017;63:51–5.

Article  Google Scholar 

Horgan R, Hage DY, Waller J, Abuhamad A, Saade G. Low-dose aspirin therapy for the prevention of preeclampsia: time to reconsider our recommendations? Am J Obstet Gynecol. 2023;229:410–8.

Article  CAS  PubMed  Google Scholar 

Tolcher MC, Sangi-Haghpeykar H, Mendez-Figueroa H, Aagaard KM. Low-dose aspirin for preeclampsia prevention: efficacy by ethnicity and race. Am J Obstet Gynecol MFM. 2020;2:100184.

Article  PubMed  Google Scholar 

Xu TT, Zhou F, Deng CY, Huang GQ, Li JK, Wang XD. Low-dose aspirin for preventing preeclampsia and its complications: a meta-analysis. J Clin Hypertens (Greenwich). 2015;17:567–73.

Article  CAS  PubMed  Google Scholar 

Walsh SW, Strauss JR. The road to low-dose aspirin therapy for the prevention of preeclampsia began with the placenta. Int J Mol Sci. 2021;22(13):6985.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fabbrizi E, Fiorentino F, Carafa V, Altucci L, Mai A, Rotili D. Emerging roles of SIRT5 in metabolism, cancer, and SARS-CoV-2 infection. Cells. 2023;12(6):852.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Yang Y, Li Y, Zhao Y, Jiang H. Sirt5 attenuates cisplatin-induced acute kidney injury through regulation of Nrf2/HO-1 and Bcl-2. Biomed Res Int. 2019;2019:4745132.

Article  PubMed  PubMed Central  Google Scholar 

Teng P, Cui K, Yao S, Fei B, Ling F, Li C, et al. SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration. Cell Death Differ. 2024;31:65–77.

Article  CAS  PubMed  Google Scholar 

Liu Z, Yu Y, Zhang X, Wang C, Pei J, Gu W. Transcriptomic profiling in hypoxia-induced trophoblast cells for preeclampsia. Placenta. 2023;136:8–17.

Article  CAS  PubMed  Google Scholar 

Liu Z, Tang Y, Zhang X, Pei J, Wang C, Liu H, et al. Crosstalk between placental trophoblast and decidual immune cells in recurrent miscarriage. Int J Med Sci. 2023;20:1174–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe J, Holland OJ, et al. Mitoc