Chen YP, Chan ATC, Le QT, et al. Nasopharyngeal carcinoma. Lancet (London England). 2019;394(10192):64–80.

Article  PubMed  Google Scholar 

Chang ET, Ye W, Zeng YX, Adami HO. The evolving epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2021;30(6):1035–47.

CAS  Google Scholar 

Li WF, Chen NY, Zhang N, et al. Concurrent chemoradiotherapy with/without induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: long-term results of phase 3 randomized controlled trial. Int J Cancer. 2019;145(1):295–305.

Article  CAS  PubMed  Google Scholar 

Wee J, Tan EH, Tai BC, et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American joint committee on cancer/international union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncology Off J Am Soc Clin Oncol. 2005;23(27):6730–8.

Article  CAS  Google Scholar 

Yang J, Liang ZG, Jiang YT, et al. Efficacy and safety of concurrent chemoradiotherapy combined with induction chemotherapy or adjuvant chemotherapy in patients with stage II-IVA nasopharyngeal carcinoma: a propensity score matching analysis and meta-analysis. Front Oncol. 2021;11:778836.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee AW, Ma BB, Ng WT, Chan AT. Management of nasopharyngeal carcinoma: current practice and future perspective. J Clin Oncology Off J Am Soc Clin Oncol. 2015;33(29):3356–64.

Article  Google Scholar 

Su WH, Hildesheim A, Chang YS. Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers. Front Oncol. 2013;3:299.

Article  PubMed  PubMed Central  Google Scholar 

Larbcharoensub N, Mahaprom K, Jiarpinitnun C, et al. Characterization of PD-L1 and PD-1 expression and CD8 + tumor-infiltrating lymphocyte in Epstein-Barr virus-associated nasopharyngeal carcinoma. Am J Clin Oncol. 2018;41(12):1204–10.

Article  CAS  PubMed  Google Scholar 

Yang Y, Qu S, Li J, et al. Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2021;22(8):1162–74.

Article  CAS  PubMed  Google Scholar 

Mai HQ, Chen QY, Chen D, et al. Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial. Nat Med. 2021;27(9):1536–43.

Article  CAS  PubMed  Google Scholar 

Kato T, Noma K, Ohara T, et al. Cancer-Associated fibroblasts affect Intratumoral CD8(+) and FoxP3(+) T cells Via IL6 in the tumor microenvironment. Clin cancer Res Off J Am Association Cancer Res. 2018;24(19):4820–33.

Article  CAS  Google Scholar 

Huang C, Ding J, Huang C, et al. Abnormal variation and prognostic significance of circulating immune cells in patients with nasopharyngeal carcinoma treated with chemoradiotherapy: a prospective cohort study. Translational cancer Res. 2023;12(12):3718–27.

Article  CAS  Google Scholar 

Zhu J, Fang R, Pan Z, Qian X. Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma. BMC Cancer. 2022;22(1):716.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu T, Huang Z, Su B, et al. Prognostic significance of circulating CD19 + B lymphocytes in EBV-associated nasopharyngeal carcinoma. Med Oncol (Northwood Lond Engl). 2014;31(10):198.

Article  Google Scholar 

Kumarasamy C, Tiwary V, Sunil K, et al. Prognostic utility of platelet-lymphocyte ratio, neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in head and neck cancers: a detailed PRISMA compliant systematic review and meta-analysis. Cancers. 2021;13:16.

Article  Google Scholar 

Zeng X, Liu G, Pan Y, Li Y. Development and validation of immune inflammation-based index for predicting the clinical outcome in patients with nasopharyngeal carcinoma. J Cell Mol Med. 2020;24(15):8326–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gianni C, Palleschi M, Schepisi G, et al. Circulating inflammatory cells in patients with metastatic breast cancer: implications for treatment. Front Oncol. 2022;12:882896.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou JY, Chen T, Li W, Ye K, Wei ZB. Effect of pretreatment serum LDH and ALP levels on the prognosis of patients with nasopharyngeal carcinoma. Lin chuang er bi yan hou tou jing wai ke za zhi = J Clin Otorhinolaryngology Head Neck Surgery. 2017;31(14):1069–1073.

Lu ZJ, Liu LT, Sun XS, et al. Establishment and validation of a prognostic nomogram to predict early metastasis in nasopharyngeal carcinoma patients within six months after radiotherapy and to guide intensive treatment. Radiotherapy Oncology: J Eur Soc Therapeutic Radiol Oncol. 2021;162:202–11.

Article  CAS  Google Scholar 

Su K, Huang W, Li X, et al. Evaluation of Lactate Dehydrogenase and Alkaline phosphatase as predictive biomarkers in the prognosis of hepatocellular carcinoma and development of a new nomogram. J Hepatocellular Carcinoma. 2023;10:69–79.

Article  Google Scholar 

Yang H, Wang K, Liang Z, et al. Prognostic role of pre-treatment serum albumin in patients with nasopharyngeal carcinoma: a meta-analysis and systematic review. Clin Otolaryngology Off J ENT-UK Official J Neth Soc Oto-Rhino-Laryngology Cervico-Facial Surg. 2020;45(2):167–76.

Article  Google Scholar 

Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity. 2004;21(2):137–48.

Article  CAS  PubMed  Google Scholar 

Philip M, Schietinger A. CD8(+) T cell differentiation and dysfunction in cancer. Nat Rev Immunol. 2022;22(4):209–23.

Article  CAS  PubMed  Google Scholar 

Huff WX, Kwon JH, Henriquez M et al. The evolving role of CD8(+)CD28(-) immunosenescent T cells in cancer immunology. Int J Mol Sci 2019;20(11).

Xu X, Wei F, Xiao L, et al. High proportion of circulating CD8 + CD28- senescent T cells is an independent predictor of distant metastasis in nasopharyngeal canrcinoma after radiotherapy. J Translational Med. 2023;21(1):64.

Article  CAS  Google Scholar 

Chen M, Jin F, Ma L. The detection and significance of T cells in nasopharyngeal carcinoma patients. J Cancer Res Ther. 2018;14(Supplement):S331–5.

Article  CAS  PubMed  Google Scholar 

Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Q, Yu L, Yang P, Hu Q. Prognostic value of inflammatory markers in nasopharyngeal carcinoma patients in the intensity-modulated radiotherapy era. Cancer Manage Res. 2021;13:6799–810.

Article  Google Scholar 

Zhang J, Feng W, Ye Z, et al. Prognostic significance of platelet-to-lymphocyte ratio in patients with nasopharyngeal carcinoma: a meta-analysis. Future Oncol (London England). 2020;16(5):117–27.

Article  CAS  Google Scholar 

Xu XR, Zhang D, Oswald BE, et al. Platelets are versatile cells: new discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond. Crit Rev Clin Lab Sci. 2016;53(6):409–30.

Article  CAS  PubMed  Google Scholar 

Laursen I, Briand P, Lykkesfeldt AE. Serum albumin as a modulator on growth of the human breast cancer cell line, MCF-7. Anticancer Res. 1990;10(2a):343–51.

CAS  PubMed  Google Scholar 

Schwartz MK. Lactic dehydrogenase. An old enzyme reborn as a cancer marker? Am J Clin Pathol. 1991;96(4):441–3.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Xu T, Wang Y, et al. Prognostic role of Lactate Dehydrogenase expression in urologic cancers: a systematic review and Meta-analysis. Oncol Res Treat. 2016;39(10):592–604.

Article  CAS  PubMed  Google Scholar 

Petrelli F, Cabiddu M, Coinu A, et al. Prognostic role of lactate dehydrogenase in solid tumors: a systematic review and meta-analysis of 76 studies. Acta Oncol (Stockholm Sweden). 2015;54(7):961–70.

Article  CAS  Google Scholar