Schieving JH, de Vries M, van Vugt JMG, Weemaes C, van Deuren M, Nicolai J, et al. Alpha-fetoprotein, a fascinating protein and biomarker in neurology. Eur J Paediatr Neurol. 2014;18:243–8.

Article  CAS  PubMed  Google Scholar 

Wang XW, Xie H. Alpha-fetoprotein enhances the proliferation of human hepatoma cells in vitro. Life Sci. 1999;64:17–23.

Article  CAS  PubMed  Google Scholar 

Renaud M, Tranchant C, Koenig M, Anheim M. Autosomal recessive cerebellar ataxias with elevated alpha-fetoprotein: uncommon diseases. Common Biomarker Mov Disord. 2020;35:2139–49.

Article  CAS  PubMed  Google Scholar 

Cuckle HS, Wald NJ, Lindenbaum RH. Maternal serum alpha-fetoprotein measurement: a screening test for Down syndrome. Lancet. 1984;1:926–9.

Article  CAS  PubMed  Google Scholar 

De Mees C, Laes J-F, Bakker J, Smitz J, Hennuy B, Van Vooren P, et al. Alpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action. Mol Cell Biol. 2006;26:2012–8.

Article  PubMed  PubMed Central  Google Scholar 

Gabant P, Forrester L, Nichols J, Van Reeth T, De Mees C, Pajack B, et al. Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Proc Natl Acad Sci U S A. 2002;99:12865–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitsuhashi N, Kobayashi S, Doki T, Kimura F, Shimizu H, Yoshidome H, et al. Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma. J Gastroenterol Hepatol. 2008;23:e189–97.

Article  CAS  PubMed  Google Scholar 

Li P, Wang S-S, Liu H, Li N, McNutt MA, Li G, et al. Elevated serum alpha fetoprotein levels promote pathological progression of hepatocellular carcinoma. World J Gastroenterol. 2011;17:4563–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirajima S, Komatsu S, Ichikawa D, Kubota T, Okamoto K, Shiozaki A, et al. Liver metastasis is the only independent prognostic factor in AFP-producing gastric cancer. World J Gastroenterol. 2013;19:6055–61.

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Röcken C, Treiber G, Jentsch-Ulrich K, Malfertheiner P, Ebert MPA. Clinical implications of alpha-fetoprotein expression in gastric adenocarcinoma. Dig Dis. 2003;21:357–62.

Article  PubMed  Google Scholar 

Li M, Zhou S, Liu X, Li P, McNutt MA, Li G. alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand. Cancer Lett. 2007;249:227–34.

Article  CAS  PubMed  Google Scholar 

Li M, Liu X, Zhou S, Li P, Li G. Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes. BMC Cancer. 2005;5:96.

Article  PubMed  PubMed Central  Google Scholar 

Wang S, Zhu M, Wang Q, Hou Y, Li L, Weng H, et al. Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling. Cell Death Dis. 2018;9:1027.

Article  PubMed  PubMed Central  Google Scholar 

Chen T, Dai X, Dai J, Ding C, Zhang Z, Lin Z, et al. AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway. Cell Death Dis. 2020;11:822.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Wang S, Jiang W, Li H, Liu Z, Zhang C, et al. Impact of intracellular alpha fetoprotein on retinoic acid receptors-mediated expression of GADD153 in human hepatoma cell lines. Int J Cancer. 2012;130:754–64.

Article  CAS  PubMed  Google Scholar 

Wang S, Jiang W, Chen X, Zhang C, Li H, Hou W, et al. Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma. J Hepatol. 2012;57:322–9.

Article  CAS  PubMed  Google Scholar 

Zhang C, Chen X, Liu H, Li H, Jiang W, Hou W, et al. Alpha fetoprotein mediates HBx induced carcinogenesis in the hepatocyte cytoplasm. Int J Cancer. 2015;137:1818–29.

Article  CAS  PubMed  Google Scholar 

Parpart S, Roessler S, Dong F, Rao V, Takai A, Ji J, et al. Modulation of miR-29 expression by α-fetoprotein is linked to the hepatocellular carcinoma epigenome. Hepatology. 2014;60:872–83.

Article  CAS  PubMed  Google Scholar 

Stine ZE, Walton ZE, Altman BJ, Hsieh AL, Dang CV. MYC, metabolism, and cancer. Cancer Discov. 2015;5:1024–39.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu P, Ge M, Hu J, Li X, Che L, Sun K, et al. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis. Hepatology. 2017;66:167–81.

Article  CAS  PubMed  Google Scholar 

Dang CV. MYC on the path to cancer. Cell. 2012;149:22–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anauate AC, Leal MF, Calcagno DQ, Gigek CO, Karia BTR, Wisnieski F, et al. The complex network between MYC oncogene and microRNAs in gastric cancer: an overview. Int J Mol Sci. 2020;21:1782.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol. 1999;19.

Gherardi E, Birchmeier W, Birchmeier C, Vande Woude G. Targeting MET in cancer: rationale and progress. Nat Rev Cancer. 2012;12:89.

Article  CAS  PubMed  Google Scholar 

Cecchi F, Rabe DC, Bottaro DP. Targeting the HGF/Met signalling pathway in cancer. Eur J Cancer. 2010;46:1260–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han H, Jain AD, Truica MI, Izquierdo-Ferrer J, Anker JF, Lysy B, et al. Small-molecule MYC inhibitors suppress tumor growth and enhance immunotherapy. Cancer Cell. 2019;36:483.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dejure FR, Royla N, Herold S, Kalb J, Walz S, Ade CP, et al. The MYC mRNA 3′-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels. EMBO J. 2017;36:1854–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guan L, Zou Q, Liu Q, Lin Y, Chen S. HSP90 inhibitor ganetespib (STA-9090) inhibits tumor growth in c-Myc-dependent esophageal squamous cell carcinoma. Onco Targets Ther. 2020;13:2997–3011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Pashtan I, Tsutsumi S, Xu W, Neckers L. Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors. Cell Cycle. 2009;8:2050–6.

Article  CAS  PubMed  Google Scholar 

Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, et al. Quantitative analysis of Hsp90-client interactions reveals principles of substrate recognition. Cell. 2012;150:987–1001.

Article  CAS