Limandjaja GC, Niessen FB, Scheper RJ, Gibbs S. Hypertrophic scars and keloids: overview of the evidence and practical guide for differentiating between these abnormal scars. Exp Dermatol. 2021;30:146–61.

Article  CAS  PubMed  Google Scholar 

He S, Liu X, Yang Y, Huang W, Xu S, Yang S, Zhang X, Roberts MS. Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. Br J Dermatol. 2010;162:538–46.

Article  CAS  PubMed  Google Scholar 

Zhang T, Wang XF, Wang ZC, Lou D, Fang QQ, Hu YY, Zhao WY, Zhang LY, Wu LH, Tan WQ. Current potential therapeutic strategies targeting the TGF-beta/Smad signaling pathway to attenuate keloid and hypertrophic scar formation. Biomed Pharmacother. 2020;129:110287.

Article  CAS  PubMed  Google Scholar 

Elsaie ML. Update on management of keloid and hypertrophic scars: a systemic review. J Cosmet Dermatol. 2021;20:2729–38.

Article  PubMed  Google Scholar 

Morelli Coppola M, Salzillo R, Segreto F, Persichetti P. Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives. Clin Cosmet Investig Dermatol. 2018;11:387–96.

Article  PubMed  PubMed Central  Google Scholar 

Barnes L, Kaya G, Rollason V. Topical corticosteroid-induced skin atrophy: a comprehensive review. Drug Saf. 2015;38:493–509.

Article  CAS  PubMed  Google Scholar 

Berman B, Bieley HC. Keloids. J Am Acad Dermatol. 1995;33:117–23.

Article  CAS  PubMed  Google Scholar 

Bürgi W, Schmid K. Preparation and properties of Zn-α2-glycoprotein of normal human plasma. J Biol Chem. 1961;236:1066–74.

Article  PubMed  Google Scholar 

Tada T, Ohkubo I, Niwa M, Sasaki M, Tateyama H, Eimoto T. Immunohistochemical localization of Zn-A2-glycoprotein in normal human tissues. J Histochem Cytochem. 1991;39:1221–6.

Article  CAS  PubMed  Google Scholar 

Kong B, Michalski CW, Hong X, Valkovskaya N, Rieder S, Abiatari I, Streit S, Erkan M, Esposito I, Friess H, Kleeff J. AZGP1 is a tumor suppressor in pancreatic cancer inducing mesenchymal-to-epithelial transdifferentiation by inhibiting TGF-beta-mediated ERK signaling. Oncogene. 2010;29:5146–58.

Article  CAS  PubMed  Google Scholar 

Hao Y, Baker D, Ten Dijke P. TGF-beta-mediated epithelial-mesenchymal transition and cancer metastasis. Int J Mol Sci. 2019;20:2767.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen SH, Arany I, Apisarnthanarax N, Rajaraman S, Tyring SK, Horikoshi T, Brysk H, Brysk MM. Response of keratinocytes from normal and psoriatic epidermis to interferon-gamma differs in the expression of zinc-alpha(2)-glycoprotein and cathepsin D. FASEB J. 2000;14:565–71.

Article  CAS  PubMed  Google Scholar 

Bao Y, Bing C, Hunter L, Jenkins JR, Wabitsch M, Trayhurn P. Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes. FEBS Lett. 2005;579:41–7.

Article  CAS  PubMed  Google Scholar 

Noh JY, Shin JU, Kim JH, Kim SH, Kim BM, Kim YH, Park S, Kim TG, Shin KO, Park K, Lee KH. ZAG regulates the skin barrier and immunity in atopic dermatitis. J Invest Dermatol. 2019;139:1648–57.

Article  CAS  PubMed  Google Scholar 

Limandjaja GC, van den Broek LJ, Breetveld M, Waaijman T, Monstrey S, de Boer EM, Scheper RJ, Niessen FB, Gibbs S. Characterization of in vitro reconstructed human normotrophic, hypertrophic, and keloid scar models. Tissue Eng Part C Methods. 2018;24:242–53.

Article  CAS  PubMed  Google Scholar 

Limandjaja GC, Niessen FB, Scheper RJ, Gibbs S. The keloid disorder: heterogeneity, histopathology, mechanisms and models. Front Cell Dev Biol. 2020;8:360.

Article  PubMed  PubMed Central  Google Scholar 

Dong X, Mao S, Wen H. Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation. Biomed Rep. 2013;1:833–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jung BK, Roh TS, Roh H, Lee JH, Yun CO, Lee WJ. Effect of mortalin on scar formation in human dermal fibroblasts and a rat incisional scar model. Int J Mol Sci. 2022;2022:23.

Google Scholar 

Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J. Keloids: the paradigm of skin fibrosis-pathomechanisms and treatment. Matrix Biol. 2016;51:37–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghahary A, Shen YJ, Scott PG, Tredget EE. Expression of mRNA for transforming growth factor-beta 1 is reduced in hypertrophic scar and normal dermal fibroblasts following serial passage in vitro. J Invest Dermatol. 1994;103:684–6.

Article  CAS  PubMed  Google Scholar 

Iernacka A, Dobaczewski M, Frangogiannis NG. TGF-β signaling in fibrosis. Growth Factors. 2011;29:196–202.

Article  Google Scholar 

Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685–700.

Article  CAS  PubMed  Google Scholar 

Fasciglione GF, Gioia M, Tsukada H, Liang J, Iundusi R, Tarantino U, Coletta M, Pourmotabbed T, Marini S. The collagenolytic action of MMP-1 is regulated by the interaction between the catalytic domain and the hinge region. J Biol Inorg Chem. 2012;17:663–72.

Article  CAS  PubMed  Google Scholar 

Schiller M, Javelaud D, Mauviel A. TGF-beta-induced SMAD signaling and gene regulation: consequences for extracellular matrix remodeling and wound healing. J Dermatol Sci. 2004;35:83–92.

Article  CAS  PubMed  Google Scholar 

Bhogal RK, Stoica CM, McGaha TL, Bona CA. Molecular aspects of regulation of collagen gene expression in fibrosis. J Clin Immunol. 2005;25:592–603.

Article  CAS  PubMed  Google Scholar 

Latronico T, Mascia C, Pati I, Zuccala P, Mengoni F, Marocco R, Tieghi T, Belvisi V, Lichtner M, Vullo V, Mastroianni CM, Liuzzi GM. Liver fibrosis in HCV monoinfected and HIV/HCV coinfected patients: dysregulation of matrix metalloproteinases (MMPs) and their tissue inhibitors TIMPs and effect of HCV protease inhibitors. Int J Mol Sci. 2016;17:455.

Article  PubMed  PubMed Central  Google Scholar 

Fujiwara M, Muragaki Y, Ooshima A. Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration. Br J Dermatol. 2005;153:295–300.

Article  CAS  PubMed  Google Scholar 

Dubois V, Delort L, Mishellany F, Jarde T, Billard H, Lequeux C, et al. Zinc-α2-glycoprotein: a new biomarker of breast cancer? Anticancer Res. 2010;30:2919–25.

CAS  PubMed  Google Scholar 

Hassan MI, Waheed A, Yadav S, Singh TP, Ahmad F. Zinc alpha 2-glycoprotein: a multidisciplinary protein. Mol Cancer Res. 2008;6:892–906.

Article  CAS  PubMed  Google Scholar 

Ji D, Li M, Zhan T, Yao Y, Shen J, Tian H, Zhang Z, Gu J. Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients. Carcinogenesis. 2013;34:1265–72.

Article  CAS  PubMed  Google Scholar 

Horiguchi K, Shirakihara T, Nakano A, Imamura T, Miyazono K, Saitoh M. Role of ras signaling in the induction of snail by transforming growth factor-beta. J Biol Chem. 2009;284:245–53.

Article  CAS