Benson AB, Venook AP, Al-Hawary MM, Azad N, Chen YJ, Ciombor KK et al (2022) Rectal cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw 20(10):1139–1167

Article  CAS  PubMed  Google Scholar 

Conroy T, Bosset JF, Etienne PL, Rio E, Francois E, Mesgouez-Nebout N et al (2021) Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 22(5):702–715

Article  CAS  PubMed  Google Scholar 

Fokas E, Allgauer M, Polat B, Klautke G, Grabenbauer GG, Fietkau R et al (2019) Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO/ARO/AIO-12. J Clin Oncol 37(34):3212–3222

Article  CAS  PubMed  Google Scholar 

Fokas E, Schlenska-Lange A, Polat B, Klautke G, Grabenbauer GG, Fietkau R et al (2022) Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for patients with locally advanced rectal cancer: long-term results of the CAO/ARO/AIO-12 randomized clinical trial. JAMA Oncol 8(1):e215445

Article  PubMed  Google Scholar 

Jin J, Tang Y, Hu C, Jiang LM, Jiang J, Li N et al (2022) Multicenter, randomized, phase III trial of short-term radiotherapy plus chemotherapy versus long-term chemoradiotherapy in locally advanced rectal cancer (STELLAR). J Clin Oncol 40(15):1681–1692

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R et al (2004) Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351(17):1731–1740

Article  CAS  PubMed  Google Scholar 

Downing A, Glaser AW, Finan PJ, Wright P, Thomas JD, Gilbert A et al (2019) Functional outcomes and health-related quality of life after curative treatment for rectal cancer: a population-level study in england. Int J Radiat Oncol Biol Phys 103(5):1132–1142

Article  PubMed  Google Scholar 

Wolff HA, Conradi LC, Beissbarth T, Leha A, Hohenberger W, Merkel S et al (2013) Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: long-term results of the German CAO/ARO/AIO-94 phase III trial. Radiother Oncol 108(1):48–54

Article  CAS  PubMed  Google Scholar 

Verheij FS, Omer DM, Williams H, Lin ST, Qin LX, Buckley JT et al (2024) Long-term results of organ preservation in patients with rectal Adenocarcinoma treated with total neoadjuvant therapy: the randomized phase II OPRA trial. J Clin Oncol 42(5):500–506

Article  CAS  PubMed  Google Scholar 

Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, Yuval JB, Thompson HM et al (2022) Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol 40(23):2546–2556

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schrag D, Shi Q, Weiser MR, Gollub MJ, Saltz LB, Musher BL et al (2023) Preoperative treatment of locally advanced rectal cancer. N Engl J Med 389(4):322–334

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mantello G, Galofaro E, Caravatta L, Di Carlo C, Montrone S, Arpa D et al (2023) Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group. Radiol Med 128(7):869–876

Article  PubMed  PubMed Central  Google Scholar 

Swartjes H, van Rees JM, van Erning FN, Verheij M, Verhoef C, de Wilt JHW et al (2023) Locally recurrent rectal cancer: toward a second chance at cure? A population-based, retrospective cohort study. Ann Surg Oncol 30(7):3915–3924

Article  PubMed  PubMed Central  Google Scholar 

Hagemans JAW, van Rees JM, Alberda WJ, Rothbarth J, Nuyttens J, van Meerten E et al (2020) Locally recurrent rectal cancer; long-term outcome of curative surgical and non-surgical treatment of 447 consecutive patients in a tertiary referral centre. Eur J Surg Oncol 46(3):448–454

Article  CAS  PubMed  Google Scholar 

Valentini V, Morganti AG, Gambacorta MA, Mohiuddin M, Doglietto GB, Coco C et al (2006) Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: a multicentric phase II study. Int J Radiat Oncol Biol Phys 64(4):1129–1139

Article  PubMed  Google Scholar 

Voogt ELK, Nordkamp S, Nieuwenhuijzen GAP, Creemers GJ, Peulen HMU, Rutten HJT et al (2021) Curative treatment of locally recurrent rectal cancer: is induction chemotherapy warranted? Br J Surg 108(6):e213–e4

Article  CAS  PubMed  Google Scholar 

Denost Q, Frison E, Salut C, Sitta R, Rullier A, Harji D et al (2021) A phase III randomized trial evaluating chemotherapy followed by pelvic reirradiation versus chemotherapy alone as preoperative treatment for locally recurrent rectal cancer—GRECCAR 15 trial protocol. Colorectal Dis 23(7):1909–1918

Article  CAS  PubMed  Google Scholar 

Cisel B, Pietrzak L, Michalski W, Wyrwicz L, Rutkowski A, Kosakowska E et al (2019) Long-course preoperative chemoradiation versus 5 x 5 Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: long-term results of the randomized polish II study. Ann Oncol 30(8):1298–1303

Article  CAS  PubMed  Google Scholar 

Rodel C, Graeven U, Fietkau R, Hohenberger W, Hothorn T, Arnold D et al (2015) Oxaliplatin added to fluorouracil-based preoperative chemoradiotherapy and postoperative chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open-label, randomised, phase 3 trial. Lancet Oncol 16(8):979–989

Article  PubMed  Google Scholar 

Glimelius B (2003) Recurrent rectal cancer. The pre-irradiated primary tumour: can more radiotherapy be given? Colorectal Dis 5(5):501–503

Article  PubMed  Google Scholar 

Bosman SJ, Holman FA, Nieuwenhuijzen GA, Martijn H, Creemers GJ, Rutten HJ (2014) Feasibility of reirradiation in the treatment of locally recurrent rectal cancer. Br J Surg 101(10):1280–1289

Article  CAS  PubMed  Google Scholar 

Calvo FA, Sole CV, Rutten HJ, Dries WJ, Lozano MA, Cambeiro M et al (2020) ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in locally recurrent rectal cancer. Clin Transl Radiat Oncol 24:41–48

PubMed  PubMed Central  Google Scholar 

Voogt ELK, van Rees JM, Hagemans JAW, Rothbarth J, Nieuwenhuijzen GAP, Cnossen JS et al (2021) Intraoperative electron beam radiation therapy (IOERT) versus high-dose-rate Intraoperative brachytherapy (HDR-IORT) in patients with an R1 resection for locally advanced or locally recurrent rectal cancer. Int J Radiat Oncol Biol Phys 110(4):1032–1043

Article  PubMed  Google Scholar 

Harrison LB, Minsky BD, Enker WE, Mychalczak B, Guillem J, Paty PB et al (1998) High dose rate intraoperative radiation therapy (HDR-IORT) as part of the management strategy for locally advanced primary and recurrent rectal cancer. Int J Radiat Oncol Biol Phys 42(2):325–330

Article  CAS  PubMed  Google Scholar 

Keogh C, O’Sullivan NJ, Temperley HC, Flood MP, Ting P, Walsh C et al (2023) Redo pelvic surgery and combined metastectomy for locally recurrent rectal cancer with known oligometastatic disease: a multicentre review. Cancers 15(18)

Rodel C, Grabenbauer GG, Matzel KE, Schick C, Fietkau R, Papadopoulos T et al (2000) Extensive surgery after high-dose preoperative chemoradiotherapy for locally advanced recurrent rectal cancer. Dis Colon Rectum 43(3):312–319

Article  CAS  PubMed  Google Scholar 

Terezakis S, Morikawa L, Wu A, Zhang Z, Shi W, Weiser MR et al (2015) Long-term survival after high-dose-rate Brachytherapy for locally advanced or recurrent colorectal adenocarcinoma. Ann Surg Oncol 22(7):2168–2178

Article  PubMed  PubMed Central  Google Scholar 

Calvo FA, Sole CV, Alvarez de Sierra P, Gomez-Espi M, Blanco J, Lozano MA et al (2013) Prognostic impact of external beam radiation therapy in patients treated with and without extended surgery and intraoperative electrons for locally recurrent rectal cancer: 16-year experience in a single institution. Int J Radiat Oncol Biol Phys 86(5):892–900

Article  PubMed  Google Scholar 

Roeder F, Goetz JM, Habl G, Bischof M, Krempien R, Buechler MW et al (2012) Intraoperative electron radiation therapy (IOERT) in the management of locally recurrent rectal cancer. BMC Cancer 12:592

Article  PubMed  PubMed Central  Google Scholar 

Alektiar KM, Zelefsky MJ, Paty PB, Guillem J, Saltz LB, Cohen AM et al (2000) High-dose-rate intraoperative brachytherapy for recurrent colorectal cancer. Int J Radiat Oncol Biol Phys 48(1):219–226