Siramshetty VB, Nickel J, Omieczynski C, Gohlke B-O, Drwal MN, Preissner R (2016) WITHDRAWN—a resource for withdrawn and discontinued drugs. Nucleic Acids Res 44(D1):D1080–D1086
Article CAS PubMed Google Scholar
Ulloa JL, Stahl S, Yates J, Woodhouse N, Kenna JG, Jones HB, Waterton JC, Hockings PD (2013) Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition. NMR Biomed 26(10):1258–1270
Article CAS PubMed PubMed Central Google Scholar
Weinmann HJ, Schuhmann-Giampieri G, Schmitt-Willich H, Vogler H, Frenzel T, Gries H (1991) A new lipophilic gadolinium chelate as a tissue-specific contrast medium for MRI. Magn Reson Med 22(2):233–237
Article CAS PubMed Google Scholar
Hamm B, Staks T, Muhler A, Bollow M, Taupitz M, Frenzel T, Wolf KJ, Weinmann HJ, Lange L (1995) Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology 195(3):785–792
Article CAS PubMed Google Scholar
Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ (2000) Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology 118(2):422–430
Article CAS PubMed Google Scholar
van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE (1999) Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther 290(1):153–157
Weinmann HJ, Bauer H, Frenzel T, Muhler A, Ebert W (1996) Mechanism of hepatic uptake of gadoxetate disodium. Acad Radiol 3(Suppl 2):S232-234
Muhler A, Clement O, Saeed M, Lake JR, Stites DP, Berthezene Y, Brasch RC (1993) Gadolinium-ethoxybenzyl-DTPA, a new liver-directed magnetic resonance contrast agent absence of acute hepatotoxic, cardiovascular, or immunogenic effects. Investig Radiol 28(1):26–32
Saito K, Ledsam J, Sourbron S, Otaka J, Araki Y, Akata S, Tokuuye K (2013) Assessing liver function using dynamic Gd-EOB-DTPA-enhanced MRI with a standard 5-phase imaging protocol. J Magn Reson Imaging 37(5):1109–1114
Pastor CM, Mullhaupt B, Stieger B (2014) The role of organic anion transporters in diagnosing liver diseases by magnetic resonance imaging. Drug Metab Dispos 42(4):675–684
Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, Weitschies W, Hosten N, Siegmund W, Kuhn JP (2012) Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging. Radiology 264(3):741–750
Kato N, Yokawa T, Tamura A, Heshiki A, Ebert W, Weinmann HJ (2002) Gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid interaction with clinical drugs in rats. Invest Radiol 37(12):680–684
Article CAS PubMed Google Scholar
Ryeom HK, Kim SH, Kim JY, Kim HJ, Lee JM, Chang YM, Kim YS, Kang DS (2004) Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Korean J Radiol 5(4):231–239
Article PubMed PubMed Central Google Scholar
Nilsson H, Blomqvist L, Douglas L, Nordell A, Janczewska I, Naslund E, Jonas E (2013) Gd-EOB-DTPA-enhanced MRI for the assessment of liver function and volume in liver cirrhosis. Br J Radiol 86(1026):20120653
Article CAS PubMed PubMed Central Google Scholar
Yamada A, Hara T, Li F, Fujinaga Y, Ueda K, Kadoya M, Doi K (2011) Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging. Radiology 260(3):727–733
Sourbron S, Sommer WH, Reiser MF, Zech CJ (2012) Combined quantification of liver perfusion and function with dynamic gadoxetic acid-enhanced MR imaging. Radiology 263(3):874–883
Dahlqvist Leinhard O, Dahlstrom N, Kihlberg J, Sandstrom P, Brismar TB, Smedby O, Lundberg P (2012) Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA: a pilot study. Eur Radiol 22(3):642–653
Article CAS PubMed Google Scholar
Noren B, Forsgren MF, Dahlqvist Leinhard O, Dahlstrom N, Kihlberg J, Romu T, Kechagias S, Almer S, Smedby O, Lundberg P (2013) Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA. Eur Radiol 23(1):174–181
Lagadec M, Doblas S, Giraudeau C, Ronot M, Lambert SA, Fasseu M, Paradis V, Moreau R, Pastor CM, Vilgrain V, Daire JL, Van Beers BE (2015) Advanced fibrosis: correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver. Radiology 274(2):379–386
Kukuk GM, Schaefer SG, Fimmers R, Hadizadeh DR, Ezziddin S, Spengler U, Schild HH, Willinek WA (2014) Hepatobiliary magnetic resonance imaging in patients with liver disease: correlation of liver enhancement with biochemical liver function tests. Eur Radiol 24(10):2482–2490
Karageorgis A, Lenhard SC, Yerby B, Forsgren MF, Liachenko S, Johansson E, Pilling MA, Peterson RA, Yang X, Williams DP, Ungersma SE, Morgan RE, Brouwer KLR, Jucker BM, Hockings PD (2017) A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function. PLoS ONE 13(5):e0197213
Melillo N, Scotcher D, Kenna JG, Green C, Hines CD, Laitinen I, Hockings PD, Ogungbenro K, Gunwhy ER, Sourbron S (2023) Use of in vivo imaging and physiologically-based kinetic modelling to predict hepatic transporter mediated drug-drug interactions in rats. Pharmaceutics 15(3):896
Article CAS PubMed PubMed Central Google Scholar
Scotcher D, Melillo N, Tadimalla S, Darwich AS, Ziemian S, Ogungbenro K, Schütz G, Sourbron S, Galetin A (2021) Physiologically based pharmacokinetic modeling of transporter-mediated hepatic disposition of imaging biomarker gadoxetate in rats. Mol Pharm 18(8):2997–3009
Article CAS PubMed PubMed Central Google Scholar
Waterton JC (2021) Survey of water proton longitudinal relaxation in liver in vivo. Magn Reson Mater Phys Biol Med 34(6):779–789
Montelius M, Sourbron S, Melillo N, Scotcher D, Galetin A, Schuetz G, Green C, Johansson E, Waterton JC, Hockings P (2021) Acute and chronic rifampicin effect on gadoxetate uptake in rats using gadoxetate DCE-MRI. In: Proceedings of the Annual Meeting & Exhibition, International Society of Magnetic Resonance in Medicine, held virtually. Abstract nr 2764. https://cds.ismrm.org/protected/21MProceedings/PDFfiles/2764.html.
Ziemian S, Green C, Sourbron S, Jost G, Schutz G, Hines CDG (2021) Ex vivo gadoxetate relaxivities in rat liver tissue and blood at five magnetic field strengths from 1.41 to 7 T. NMR Biomed 34(1):e4401
Article CAS PubMed Google Scholar
Waterton JC, Hines CDG, Hockings PD, Laitinen I, Ziemian S, Campbell S, Gottschalk M, Green C, Haase M, Hassemer K, Juretschke HP, Koehler S, Lloyd W, Luo Y, Mahmutovic Persson I, O’Connor JPB, Olsson LE, Pindoria K, Schneider JE, Sourbron S, Steinmann D, Strobel K, Tadimalla S, Teh I, Veltien A, Zhang X, Schutz G (2019) Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems. Magn Reson Imaging 59:121–129
Article PubMed PubMed Central Google Scholar
Green C, Tadimalla S, Steinmann D, Sourbron S, Koehler S, Juretschke H-P, Laitinen I, Waterton JC, Hockings PD, Hines CD (2019) Inter-site repeatability and quantitative assessment of hepatic transporter function with DCE-MRI in rats. In: Proceedings of the 27th Annual Meeting & Exhibition, International Society of Magnetic Resonance in Medicine, Montréal, QC, Canada. Abstract nr 1773. https://cds.ismrm.org/protected/19MProceedings/PDFfiles/1773.html.
Kenna JG, Waterton JC, Baudy A, Galetin A, Hines CD, Hockings P, Patel M, Scotcher D, Sourbron S, Ziemian S (2018) Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury. Drug-Induced Liver Toxicity. Springer, pp 627–651
Gunwhy ER, Tadimalla S, Waterton JC, Hockings PD, Schütz G, Green C, Kenna JG, Sourbron S (2023) A novel approach to derive robust arterial input functions for DCE-MRI in small animals. In: Proceedings of the Annual Meeting & Exhibition, International Society of Magnetic Resonance in Medicine, Toronto, ON, Canada. Abstract nr 2761.
Kenna JG, Green C, Hines CD, Laitinen I, Galetin A, Hockings PD, Melillo N, Montelius M, Scotcher D, Sourbron S, Waterton JC, Schütz G (2021) In vivo imaging and evaluation of drug-drug interaction risk arising via hepatobiliary transporters. In: Proceedings of the 60th Annual Meeting, Society of Toxicology, held virtually. p 157. Abstract nr 2358. https://www.toxicology.org/pubs/docs/Tox/2021Tox.pdf.
Sourbron S (2020) plaresmedima/PMI-0.4-TRISTAN-RATS: TRISTAN RATS v3.1 (v3.1). Zenodo. 10.5281/zenodo.4382479
Gunwhy ER, Sourbron S (2023) TRISTAN-rat (v2.0.0). Zenodo. 10.5281/zenodo.7839203
Gunwhy ER, Green C, Laitinen I, Tadimalla S, Sourbron S, Hockings PD, Schütz G, Kenna JG, Waterton JC, Hines CDG (2023) Rat gadoxetate MRI signal dataset for the IMI-WP2-TRISTAN reproducibility study. Zenodo. https://doi.org/10.5281/zenodo.7838397
Raunig DL, McShane LM, Pennello G, Gatsonis C, Carson PL, Voyvodic JT, Wahl RL, Kurland BF, Schwarz AJ, Gönen M (2015) Quantitative imaging biomarkers: a review of statistical methods for technical performance assessment. Stat Methods Med Res 24(1):27–67
Vallat R (2018) Pingouin: statistics in python. J Open Source Softw 3(31):1026
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