Andromanakos N, Skandalakis P, Troupis T, Filippou D. Constipation of anorectal outlet obstruction: pathophysiology, evaluation and management. J Gastroenterol Hepatol. 2006;21(4):638–46.

Article  PubMed  Google Scholar 

Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(9):1582–91.

Article  PubMed  Google Scholar 

Nag A, Martin SA, Mladsi D, Olayinka-Amao O, Purser M, Vekaria RM. The humanistic and economic burden of chronic idiopathic constipation in the USA: a systematic literature review. Clin Exp Gastroenterol. 2020;13:255–65.

Article  PubMed  PubMed Central  Google Scholar 

Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, Gangarosa LM, Thiny MT, Stizenberg K, Morgan DR. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143(5):1179–87.

Article  PubMed  Google Scholar 

Rao SS, Brenner DM. Efficacy and safety of over-the-counter therapies for chronic constipation: an updated systematic review. Am J Gastroenterol. 2021;116(6):1156.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang J-F, Sun Z-M, Li J-X. Clinical efficacy of Qi Di laxative decoction in the treatment of functional constipation: a protocol for systematic review and meta-analysis. Medicine. 2020;99(51): e23806.

Article  PubMed  PubMed Central  Google Scholar 

Rao SS, Lembo A, Chey WD, Friedenberg K, Quigley EM. Effects of the vibrating capsule on colonic circadian rhythm and bowel symptoms in chronic idiopathic constipation. Neurogastroenterol Motil. 2020;32(11): e13890.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ulbricht C, Conquer J, Costa D, Hamilton W, Higdon ER, Isaac R, Rusie E, Rychlik I, Serrano JMG, Tanguay-Colucci S. An evidence-based systematic review of senna (Cassia senna) by the Natural Standard Research Collaboration. J Diet Suppl. 2011;8(2):189–238.

Article  PubMed  CAS  Google Scholar 

Heidelbaugh J, Martinez de Andino N, Pineles D, Poppers DM. Diagnosing constipation spectrum disorders in a primary care setting. J Clin Med. 2021;10(5):1092.

Yang D, Wang H, Liu Q, Yuan P, Chen T, Zhang L, Yang S, Zhou Z, Lu Y, Du G. Structural landscape on a series of rhein: Berberine cocrystal salt solvates: the formation, dissolution elucidation from experimental and theoretical investigations. Chin Chem Lett. 2022;33(6):3207–11.

Article  CAS  Google Scholar 

Huang T, Ning Z, Hu D, Zhang M, Zhao L, Lin C, Zhong LL, Yang Z, Xu H, Bian Z. Uncovering the mechanisms of Chinese herbal medicine (MaZiRenWan) for functional constipation by focused network pharmacology approach. Front Pharmacol. 2018;9:270.

Article  PubMed  PubMed Central  Google Scholar 

Zhong LL, Cheng C-W, Kun W, Dai L, Hu D-D, Ning Z-W, Xiao H-T, Lin C-Y, Zhao L, Huang T. Efficacy of MaZiRenWan, a Chinese herbal medicine, in patients with functional constipation in a randomized controlled trial. Clin Gastroenterol Hepatol. 2019;17(7):1303–10.

Lin H, Zhang H, Xiang X. Clinical observation of 68 cases of side effects of Chinese traditional medicine in treating constipation with psychotropic drugs. Nei Mongol J Tradit Chin Med. 2008;27(7):17–8.

Google Scholar 

Li X, Li H, Yang M. Therapeutic effect of modified MaZiRen pill for treating constipation caused by opium alike. Chin J Exp Tradit Med Formulae. 2012;18:312–4.

Google Scholar 

Lu Y. Treatment of 45 cases of constipation caused by chemotherapy with hemp seed pill. Henan Tradit Chin Med. 2014;34:810–1.

Google Scholar 

Chang Y. A clinical Study on the treatment of functional chronic constipation in children with hemp seed pill. Chin Pediatr Integr Tradit West Med. 2017;9:216–8.

Google Scholar 

He J, Wang L, Wang Y, Li Z, Chen F, Liu Z. Metabolomics combined with network pharmacology uncovers effective targets of Tao-Hong-Si-Wu decoction for its protection from sepsis-associated acute lung injury. J Anal Test. 2023;7(2):172–86.

Article  Google Scholar 

Xiang L, Ru Y, Shi J, Wang L, Zhao H, Huang Y, Cai Z. Derivatization of N-acyl glycines by 3-nitrophenylhydrazine for targeted metabolomics analysis and their application to the study of diabetes progression in mice. Anal Chem. 2023;95(4):2183–91.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin S, Zhang H, Wang C, Su X-L, Song Y, Wu P, Yang Z, Wong M-H, Cai Z, Zheng C. Metabolomics reveal nanoplastic-induced mitochondrial damage in human liver and lung cells. Environ Sci Technol. 2022;56(17):12483–93.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang H-J, Li B, Zhang M-T, Chai C-F, Li X-R, Li N, Xiao H, Bian W. Mass spectrometry and mass spectrometry imaging-based thyroid cancer analysis. J Anal Test. 2022;6(3):235–46.

Article  Google Scholar 

Nicholson JK, Wilson ID. Understanding ‘global’ systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov. 2003;2(8):668–76.

Article  PubMed  CAS  Google Scholar 

Mattoli L, Gianni M, Burico M. Mass spectrometry-based metabolomic analysis as a tool for quality control of natural complex products. Mass Spectrom Rev. 2023;42(4):1358–96.

Article  PubMed  CAS  Google Scholar 

Zhang R, Liu X, Wang T, Yu J, Wang M, Sun J, Yu X, Niu N, Chen L. HPLC fingerprint combined with chemometrics and network pharmacology for Q-markers prediction analysis of Saposhnikovia divaricata. J Anal Test. 2024;8(1):83–94.

Article  Google Scholar 

Liu Y, Ju Y, Qin X. Studies on the compatibility mechanism and material basis of Danggui Buxue decoction against anemia mice using metabonomics and network pharmacology. J Pharm Pharmacol. 2021;73(6):767–77.

Article  PubMed  Google Scholar 

Zhou Y, Dai Z, Deng K, Wang Y, Ying J, Chu D, Zhou J, Tang C. Eight Zhes Decoction ameliorates the lipid dysfunction of nonalcoholic fatty liver disease using integrated lipidomics, network pharmacology and pharmacokinetics. J Pharm Anal. 2023. https://doi.org/10.1016/j.jpha.2023.05.012.

Article  PubMed  PubMed Central  Google Scholar 

Yu H, Zhang L, Yang R, Jiang Y, Liao J, Chai S, Deng X, Wang L, Pu X, Zhang Y. Integrated multiomics and synergistic functional network revealed the mechanism in the tolerance of different ecotypes of Salvia miltiorrhiza Bge. to doxycycline pollution. Environ Sci Technol. 2023;57(26):9603–14.

Article  PubMed  CAS  Google Scholar 

Lam KS. Discovery of novel metabolites from marine actinomycetes. Curr Opin Microbiol. 2006;9(3):245–51.

Article  PubMed  CAS  Google Scholar 

Want EJ, Nordström A, Morita H, Siuzdak G. From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics. J Proteome Res. 2007;6(2):459–68.

Article  PubMed  CAS  Google Scholar 

Cheng C-W, Bian Z-X, Zhu L-X, Wu JC, Sung JJ. Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation. Am J Gastroenterol. 2011;106(1):120–9.

Article  PubMed  Google Scholar 

Luan H, Ji F, Chen Y, Cai Z. statTarget: a streamlined tool for signal drift correction and interpretations of quantitative mass spectrometry-based omics data. Anal Chim Acta. 2018;1036:66–72.

Article  PubMed  CAS  Google Scholar 

Xiang L, Wang L, Xia Y, Wang Y, Shi J, Zhang C-L, Xie L, Ru Y, Cheng CK, Pu Y. Exercise alleviates diabetic kidney disease through PPARδ-CPT1α pathway-dependent fatty acid β-oxidation. The Innovation Life. 2024; https://doi.org/10.59717/j.xinn-life.2024.100065

Bai LL, Chen H, Zhou P, Yu J. Identification of tumor necrosis factor-alpha (TNF-α) inhibitor in rheumatoid arthritis using network pharmacology and molecular docking. front Pharmacol. 2021;12:1247.

Article  Google Scholar 

Liu Y, Grimm M, Dai W-T, Hou M-C, Xiao Z-X, Cao Y. CB-Dock: a web server for cavity detection-guided protein–ligand blind docking. Acta Pharmacol Sin. 2020;41(1):138–44.

Article  PubMed  Google Scholar 

Yang J, Guo W, Xu X, Zhao L, Xu Y, Wang Y. Analysis of fatty acid in biological samples using liquid chromatography–quadrupole-orbitrap mass spectrometry under parallel reaction monitoring mode. J Anal Test. 2023;8:1–8.

Google Scholar 

Yu J-B, Zhao Z-X, Peng R, Pan L-B, Fu J, Ma S-R, Han P, Cong L, Zhang Z-W, Sun L-X. Gut microbiota-based pharmacokinetics and the antidepressant mechanism of paeoniflorin. Front Pharmacol. 2019;10:268.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jaswal V, Palanivelu J, Ramalingam C. Effects of the Gut microbiota on amygdalin and its use as an anti-cancer therapy: substantial review on the key components involved in altering dose efficacy and toxicity. Biochem Biophys Rep. 2018;14:125–32.

PubMed