Ranke MB, Wit JM. Growth hormone - past, present and future. Nat Rev Endocrinol. 2018;14:285–300.

Article  CAS  PubMed  Google Scholar 

Cheng RQ, Ying YQ, Qiu ZQ, Fu JF, Gong CX, Yang YL, et al. Early recombinant human growth hormone treatment improves mental development and alleviates deterioration of motor function in infants and young children with Prader-Willi syndrome. World J Pediatr. 2023;19:438–49.

Article  CAS  PubMed  Google Scholar 

Bamba V, Kanakatti SR. Approach to the patient: safety of growth hormone replacement in children and adolescents. J Clin Endocrinol Metab. 2022;107:847–61.

Article  PubMed  Google Scholar 

Soliman AT, Elawwa A, Itani M, Jour C, De Sanctis V. Responses to growth hormone (GH) therapy in short children with normal GH secretion and no bone age delay: an analysis of potential factors affecting their response to rhGH therapy. A controlled study. Acta Biomed. 2019;90:43–51.

CAS  PubMed  PubMed Central  Google Scholar 

Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, et al. Growth hormone deficit: influence of puberty on the response to treatment. An Pediatr (Engl Ed). 2022;96:221–9 (in Spanish).

Article  PubMed  Google Scholar 

Ismail NA, Eldin Metwaly NS, El-Moguy FA, Hafez MH, Abd El Dayem SM, Farid TM. Bone age is the best predictor of growth response to recombinant human growth hormone in Turner’s syndrome. Indian J Hum Genet. 2010;16:119–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dörr HG, Bettendorf M, Hauffa BP, Mehls O, Rohrer T, Stahnke N, et al. Different relationships between the first 2 years on growth hormone treatment and the d3-growth hormone receptor polymorphism in short small-for-gestational-age (SGA) children. Clin Endocrinol (Oxf). 2011;75:656–60.

Article  PubMed  Google Scholar 

Binder G, Baur F, Schweizer R, Ranke MB. The d3-growth hormone (GH) receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short small-for-gestational-age children. J Clin Endocrinol Metab. 2006;91:659–64.

Article  CAS  PubMed  Google Scholar 

Göpel E, Rockstroh D, Pfäffle H, Schlicke M, Pozza SB, Gannagé-Yared MH, et al. A Comprehensive cohort analysis comparing growth and GH therapy response in IGF1R mutation carriers and SGA children. J Clin Endocrinol Metab. 2020;105:e1705–17.

Article  Google Scholar 

Kronenberg HM. Developmental regulation of the growth plate. Nature. 2003;423:332–6.

Article  CAS  PubMed  Google Scholar 

Creo AL, Schwenk WF 2nd. Bone age: a handy tool for pediatric providers. Pediatrics. 2017;140:e20171486.

Kvist OF, Dallora AL, Nilsson O, Anderberg P, Berglund JS, Flodmark CE, et al. Comparison of reliability of magnetic resonance imaging using cartilage and T1-weighted sequences in the assessment of the closure of the growth plates at the knee. Acta Radiol Open. 2020;9:2058460120962732.

PubMed  PubMed Central  Google Scholar 

Recht MP, Goodwin DW, Winalski CS, White LM. MRI of articular cartilage: revisiting current status and future directions. AJR Am J Roentgenol. 2005;185:899–914.

Article  PubMed  Google Scholar 

Dedouit F, Auriol J, Rousseau H, Rougé D, Crubézy E, Telmon N. Age assessment by magnetic resonance imaging of the knee: a preliminary study. Forensic Sci Int. 2012;217:e1–7.

Google Scholar 

Saint-Martin P, Rérolle C, Dedouit F, Bouilleau L, Rousseau H, Rougé D, et al. Age estimation by magnetic resonance imaging of the distal tibial epiphysis and the calcaneum. Int J Legal Med. 2013;127:1023–30.

Article  PubMed  Google Scholar 

Urschler M, Krauskopf A, Widek T, Sorantin E, Ehammer T, Borkenstein M, et al. Applicability of greulich-pyle and tanner-whitehouse grading methods to MRI when assessing hand bone age in forensic age estimation: a pilot study. Forensic Sci Int. 2016;266:281–8.

Article  PubMed  Google Scholar 

Schmeling A, Schulz R, Reisinger W, Mühler M, Wernecke KD, Geserick G. Studies on the time frame for ossification of the medial clavicular epiphyseal cartilage in conventional radiography. Int J Legal Med. 2004;118:5–8.

Article  PubMed  Google Scholar 

Kellinghaus M, Schulz R, Vieth V, Schmidt S, Pfeiffer H, Schmeling A. Enhanced possibilities to make statements on the ossification status of the medial clavicular epiphysis using an amplified staging scheme in evaluating thin-slice CT scans. Int J Legal Med. 2010;124:321–5.

Article  PubMed  Google Scholar 

Vieth V, Schulz R, Heindel W, Pfeiffer H, Buerke B, Schmeling A, et al. Forensic age assessment by 3.0T MRI of the knee: proposal of a new MRI classification of ossification stages. Eur Radiol. 2018;28:3255–62.

Article  PubMed  Google Scholar 

Wilson JD. Peking union medical college hospital, a palace of endocrine treasures. J Clin Endocrinol Metab. 1993;76:815–6.

CAS  PubMed  Google Scholar 

Li H, Ji CY, Zong XN, Zhang YQ. Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years. Zhonghua Er Ke Za Zhi. 2009;47:487–92.

PubMed  Google Scholar 

Greulich WWPS. Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Stanford (CA): Stanford University Press; 1959.

Google Scholar 

Carel JC, Eugster EA, Rogol A, Ghizzoni L, Palmert MR, Antoniazzi F, et al. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics. 2009;123:e752–62.

Article  PubMed  Google Scholar 

Bangalore Krishna K, Fuqua JS, Rogol AD, Klein KO, Popovic J, Houk CP, et al. Use of gonadotropin-releasing hormone analogs in children: update by an international consortium. Horm Res Paediatr. 2019;91:357–72.

Article  CAS  PubMed  Google Scholar 

Mauras N, Ross JL, Gagliardi P, Yu YM, Hossain J, Permuy J, et al. Randomized trial of aromatase inhibitors, growth hormone, or combination in pubertal boys with idiopathic, short stature. J Clin Endocrinol Metab. 2016;101:4984–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hero M, Norjavaara E, Dunkel L. Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial. J Clin Endocrinol Metab. 2005;90:6396–402.

Article  CAS  PubMed  Google Scholar 

Bayley N, Pinneau SR. Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr. 1952;40:423–41.

Article  CAS  PubMed  Google Scholar 

Chen K, Shi W, Mao K, He W, Ahmed AM, Fang K. Design of growth trend map of children and adolescents based on bone age. Comput Intell Neurosci. 2022;2022:1325061.

PubMed  PubMed Central  Google Scholar 

Xu S, Gu X, Pan H, Zhu H, Gong F, Li Y, et al. Reference ranges for serum IGF-1 and IGFBP-3 levels in Chinese children during childhood and adolescence. Endocr J. 2010;57:221–8.

Article  CAS  PubMed  Google Scholar 

Cohen LE. Idiopathic short stature: a clinical review. JAMA. 2014;311:1787–96.

Article  PubMed  Google Scholar 

Deodati A, Cianfarani S. Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ. 2011;342:c7157.

Article  PubMed  Google Scholar 

Schena L, Meazza C, Pagani S, Paganelli V, Bozzola E, Tinelli C, et al. Efficacy of long-term growth hormone therapy in short nongrowth hormone-deficient children. J Pediatr Endocrinol Metab. 2017;30:197–201.

Article  CAS  PubMed  Google Scholar 

Lanes R, Gunczler P. Final height after combined growth hormone and gonadotrophin-releasing hormone analog therapy in short healthy children entering into normally timed puberty. Clin Endocrinol (Oxf). 1998;49:197–202.

Article  CAS  PubMed  Google Scholar 

Balducci R, Toscano V, Mangiantini A, Municchi G, Vaccaro F, Picone S, et al. Adult height in short normal adolescent girls treated with gonadotropin-releasing hormone analog and growth hormone. J Clin Endocrinol Metab. 1995;80:3596–600.

CAS  PubMed  Google Scholar 

Lazar L, Levy S, Oron T, Meyerovitch J, de Vries L, Shalitin S, et al. The beneficial effect of combined GH/GnRHa therapy in increasing adult height outcome in children with ISS. J Clin Endocrinol Metab. 2019;104:3287–95.