Executive summary: Neonatal encephalopathy and neurologic outcome, second edition. Report of the American college of obstetricians and gynecologists’ task force on neonatal encephalopathy. Obstet Gynecol. 2014;123:896–901.

Google Scholar 

Aslam S, Strickland T, Molloy EJ. Neonatal encephalopathy: need for recognition of multiple etiologies for optimal management. Front Pediatr. 2019;7:142.

Article  PubMed  PubMed Central  Google Scholar 

Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy. Early Hum Dev. 2010;86:329–38.

Article  PubMed  Google Scholar 

Nelson KB. Is it HIE? And why that matters. Acta Paediatrica. 2007;96:1113–4.

Article  PubMed  Google Scholar 

Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009;361:1349–58.

Article  CAS  PubMed  Google Scholar 

Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365:663–70.

Article  PubMed  Google Scholar 

Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353:1574–84.

Article  CAS  PubMed  Google Scholar 

Peebles PJ, Duello TM, Eickhoff JC, McAdams RM. Antenatal and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy. J Perinatol. 2020;40:63–9.

Article  CAS  PubMed  Google Scholar 

Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol. 1976;33:696–705.

Article  CAS  PubMed  Google Scholar 

Robertson CM, Finer NN, Grace MG. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr. 1989;114:753–60.

Article  CAS  PubMed  Google Scholar 

Shankaran S, Woldt E, Koepke T, Bedard MP, Nandyal R. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev. 1991;25:135–48.

Article  CAS  PubMed  Google Scholar 

Allen KA, Brandon DH. Hypoxic ischemic encephalopathy: pathophysiology and experimental treatments. Newborn Infant Nurs Rev. 2011;11:125–33.

Article  PubMed  PubMed Central  Google Scholar 

Juul SE, Comstock BA, Heagerty PJ, Mayock DE, Goodman AM, Hauge S, et al. High-dose erythropoietin for asphyxia and encephalopathy (HEAL): a randomized controlled trial - background, aims, and study protocol. Neonatology. 2018;113:331–8.

Article  CAS  PubMed  Google Scholar 

Kleuskens DG, Goncalves Costa F, Annink KV, van den Hoogen A, Alderliesten T, Groenendaal F, et al. Pathophysiology of cerebral hyperperfusion in term neonates with hypoxic-ischemic encephalopathy: a systematic review for future research. Front Pediatr. 2021;9:631258.

Article  PubMed  PubMed Central  Google Scholar 

Lawn JE, Cousens S, Zupan J, Steering LNS, T. 4 million neonatal deaths: when? where? why? Lancet. 2005;365:891–900.

Article  PubMed  Google Scholar 

Bruckmann EK, Velaphi S. Intrapartum asphyxia and hypoxic ischaemic encephalopathy in a public hospital: incidence and predictors of poor outcome. S Afr Med J. 2015;105:298–303.

Article  CAS  PubMed  Google Scholar 

Horn AR, Swingler GH, Myer L, Harrison MC, Linley LL, Nelson C, et al. Defining hypoxic ischemic encephalopathy in newborn infants: benchmarking in a South African population. J Perinat Med. 2013;41:211–7.

Article  PubMed  Google Scholar 

Pedroza-Garcia KA, Calderon-Vallejo D, Quintanar JL. Neonatal hypoxic-ischemic encephalopathy: perspectives of neuroprotective and neuroregenerative treatments. Neuropediatrics. 2022;53:402–17.

Article  CAS  PubMed  Google Scholar 

Tetorou K, Sisa C, Iqbal A, Dhillon K, Hristova M. Current therapies for neonatal hypoxic-ischaemic and infection-sensitised hypoxic-ischaemic brain damage. Front Synaptic Neurosci. 2021;13:709301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greco P, Nencini G, Piva I, Scioscia M, Volta CA, Spadaro S, et al. Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future. Acta Neurol Belg. 2020;120:277–88.

Article  CAS  PubMed  Google Scholar 

Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;1:CD003311.

Article  PubMed  PubMed Central  Google Scholar 

Thayyil S, Bassett P, Shankaran S. Questions about the HELIX trial – authors’ reply. Lancet Glob Health. 2021;9:e1654–5.

Article  CAS  PubMed  Google Scholar 

Aker K, Stoen R, Martinez-Biarge M, Thomas N. Questions about the HELIX trial. Lancet Glob Health. 2021;9:e1651.

Article  CAS  PubMed  Google Scholar 

Kainth D, Sharma A, Sankar MJ. Questions about the HELIX trial. Lancet Glob Health. 2021;9:e1652.

Article  CAS  PubMed  Google Scholar 

Kali GTJ, Pillay S, Pepper MS, Horn AR, leaders Ns. Questions about the HELIX trial. Lancet Glob Health. 2021;9:e1653.

Article  CAS  PubMed  Google Scholar 

Khurana S, Chawla D, Jain S. Questions about the HELIX trial. Lancet Glob Health. 2021;9:e1650.

Article  CAS  PubMed  Google Scholar 

Kali GT, Martinez-Biarge M, Van Zyl J, Smith J, Rutherford M. Therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy had favourable outcomes at a referral hospital in a middle-income country. Acta Paediatr. 2016;105:806–15.

Article  CAS  PubMed  Google Scholar 

Abate BB, Bimerew M, Gebremichael B, Mengesha Kassie A, Kassaw M, Gebremeskel T, et al. Effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis of randomized control trials. PLoS ONE. 2021;16:e0247229.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azzopardi D, Brocklehurst P, Edwards D, Halliday H, Levene M, Thoresen M, et al. The TOBY Study whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr. 2008;8:17.

Article  PubMed  PubMed Central  Google Scholar 

Robertson NJ, Nakakeeto M, Hagmann C, Cowan FM, Acolet D, Iwata O, et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial. The Lancet. 2008;372:801–3.

Article  Google Scholar 

Simbruner G, Mittal RA, Rohlmann F, Muche R, neo.n EnTP. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics. 2010;126:e771–8.

Article  PubMed  Google Scholar 

Tagin MA, Woolcott CG, Vincer MJ, Whyte RK, Stinson DA. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med. 2012;166:558–66.

Article  PubMed