Yi S, Wang L, Wang H, Ho MS, Zhang S. Pathogenesis of α-synuclein in Parkinson’s Disease: from a neuron-glia crosstalk perspective. Int J Mol Sci. 2022;23:14753.
Article CAS PubMed PubMed Central Google Scholar
Stefanis L. α-Synuclein in Parkinson’s disease. Cold Spring Harb Perspect Med. 2012;2:a009399.
Article PubMed PubMed Central Google Scholar
Meade RM, Fairlie DP, Mason JM. Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles. Mol Neurodegener. 2019;14:29.
Article PubMed PubMed Central Google Scholar
Kim WS, Kågedal K, Halliday GM. Alpha-synuclein biology in Lewy body diseases. Alzheimers Res Ther. 2014;6:73.
Article PubMed PubMed Central Google Scholar
Weintraub D. What’s in a name? The time has come to unify Parkinson’s disease and dementia with Lewy bodies. Mov Disord. 2023;38:1977–81.
Phongpreecha T, Gajera CR, Liu CC, Vijayaragavan K, Chang AL, Becker M, et al. Single-synapse analyses of Alzheimer’s disease implicate pathologic tau, DJ1, CD47, and ApoE. Sci Adv. 2021;7:eabk0473.
Article CAS PubMed PubMed Central Google Scholar
Tansey MG, Romero-Ramos M. Immune system responses in Parkinson’s disease: Early and dynamic. Eur J Neurosci. 2019;49:364–83.
Hirsch EC, Standaert DG. Ten unsolved questions about neuroinflammation in Parkinson’s disease. Mov Disord. 2021;36:16–24.
Pajares M, I. Rojo A, Manda G, Boscá L, Cuadrado A. Inflammation in Parkinson’s disease: mechanisms and therapeutic implications. Cells. 2020;9:1687.
Article CAS PubMed PubMed Central Google Scholar
Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol. 2022;22:657–73.
Article CAS PubMed PubMed Central Google Scholar
Tan E-K, Chao Y-X, West A, Chan L-L, Poewe W, Jankovic J. Parkinson disease and the immune system — associations, mechanisms and therapeutics. Nat Rev Neurol. 2020;16:303–18.
Harms AS, Ferreira SA, Romero-Ramos M. Periphery and brain, innate and adaptive immunity in Parkinson’s disease. Acta Neuropathol (Berl). 2021;141:527–45.
Article CAS PubMed Google Scholar
Harms AS, Yang Y-T, Tansey MG. Central and peripheral innate and adaptive immunity in Parkinson’s disease. Sci Transl Med. 2023;15:eadk3225.
Article CAS PubMed Google Scholar
Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature. 2020;577:399–404.
Article CAS PubMed PubMed Central Google Scholar
Rocha NP, Assis F, Scalzo PL, Vieira ÉLM, Barbosa IG, de Souza MS, et al. Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson’s Disease. Mol Neurobiol. 2018;55:1488–97.
Article CAS PubMed Google Scholar
Cen L, Yang C, Huang S, Zhou M, Tang X, Li K, et al. Peripheral lymphocyte subsets as a marker of Parkinson’s disease in a Chinese population. Neurosci Bull. 2017;33:493–500.
Article PubMed PubMed Central Google Scholar
Niwa F, Kuriyama N, Nakagawa M, Imanishi J. Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson’s disease. Geriatr Gerontol Int. 2012;12:102–7.
Chen Y, Qi B, Xu W, Ma B, Li L, Chen Q, et al. Clinical correlation of peripheral CD4+-cell sub-sets, their imbalance and Parkinson’s disease. Mol Med Rep. 2015;12:6105–11.
Article CAS PubMed Google Scholar
Kustrimovic N, Rasini E, Legnaro M, Marino F, Cosentino M. Expression of dopaminergic receptors on human CD4+ T lymphocytes: flow cytometric analysis of naive and memory subsets and relevance for the neuroimmunology of neurodegenerative disease. J Neuroimmune Pharmacol. 2014;9:302–12.
Su Y, Shi C, Wang T, Liu C, Yang J, Zhang S, et al. Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson’s disease. J Neurol. 2022;269:6386–94.
Article CAS PubMed Google Scholar
Hasegawa Y, Inagaki T, Sawada M, Suzumura A. Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson’s disease. Acta Neurol Scand. 2000;101:159–64.
Article CAS PubMed Google Scholar
Bessler H, Djaldetti R, Salman H, Bergman M, Djaldetti M. IL-1β, IL-2, IL-6 and TNF-α production by peripheral blood mononuclear cells from patients with Parkinson’s disease. Biomed Pharmacother. 1999;53:141–5.
Article CAS PubMed Google Scholar
Reale M, Iarlori C, Thomas A, Gambi D, Perfetti B, Di Nicola M, et al. Peripheral cytokines profile in Parkinson’s disease. Brain Behav Immun. 2009;23:55–63.
Article CAS PubMed Google Scholar
Li Y, Yang Y, Zhao A, Luo N, Niu M, Kang W, et al. Parkinson’s disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study. J Neuroinflammation. 2022;19:116.
Article PubMed PubMed Central Google Scholar
Phongpreecha T, Fernandez R, Mrdjen D, Culos A, Gajera CR, Wawro AM, et al. Single-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases. Sci Adv. 2020;6:eabd5575.
Article CAS PubMed PubMed Central Google Scholar
Grayson JM, Short SM, Lee CJ, Park N, Marsac C, Sette A, et al. T cell exhaustion is associated with cognitive status and amyloid accumulation in Alzheimer’s disease. Sci Rep. 2023;13:15779.
Article CAS PubMed PubMed Central Google Scholar
Fernández Zapata C, Giacomello G, Spruth EJ, Middeldorp J, Gallaccio G, Dehlinger A, et al. Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease. Nat Commun. 2022;13:7210.
Article PubMed PubMed Central Google Scholar
Fiala M, Lin J, Ringman J, Kermani-Arab V, Tsao G, Patel A, et al. Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2005;7:221–32.
Article CAS PubMed Google Scholar
Vasantharekha R, Priyanka HP, Nair RS, Hima L, Pratap UP, Srinivasan AV, et al. Alterations in immune responses are associated with dysfunctional intracellular signaling in peripheral blood mononuclear cells of men and women with mild cognitive impairment and Alzheimer’s disease. Mol Neurobiol. 2023 [cited 2023 Dec 20].https://doi.org/10.1007/s12035-023-03764-3
Cook DA, Kannarkat GT, Cintron AF, Butkovich LM, Fraser KB, Chang J, et al. LRRK2 levels in immune cells are increased in Parkinson’s disease. Npj Park Dis. 2017;3:1–12.
Gopinath A, Mackie P, Hashimi B, Buchanan AM, Smith AR, Bouchard R, et al. DAT and TH expression marks human Parkinson’s disease in peripheral immune cells. Npj Park Dis. 2022;8:1–14.
Jiang S-S, Wang Y-L, Xu Q-H, Gu L-Y, Kang R-Q, Yang W-Y, et al. Cytokine and chemokine map of peripheral specific immune cell subsets in Parkinson’s disease. Npj Park Dis. 2023;9:1–9.
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