Single-cell peripheral immunoprofiling of lewy body and Parkinson’s disease in a multi-site cohort

Yi S, Wang L, Wang H, Ho MS, Zhang S. Pathogenesis of α-synuclein in Parkinson’s Disease: from a neuron-glia crosstalk perspective. Int J Mol Sci. 2022;23:14753.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stefanis L. α-Synuclein in Parkinson’s disease. Cold Spring Harb Perspect Med. 2012;2:a009399.

Article  PubMed  PubMed Central  Google Scholar 

Meade RM, Fairlie DP, Mason JM. Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles. Mol Neurodegener. 2019;14:29.

Article  PubMed  PubMed Central  Google Scholar 

Kim WS, Kågedal K, Halliday GM. Alpha-synuclein biology in Lewy body diseases. Alzheimers Res Ther. 2014;6:73.

Article  PubMed  PubMed Central  Google Scholar 

Weintraub D. What’s in a name? The time has come to unify Parkinson’s disease and dementia with Lewy bodies. Mov Disord. 2023;38:1977–81.

Article  PubMed  Google Scholar 

Phongpreecha T, Gajera CR, Liu CC, Vijayaragavan K, Chang AL, Becker M, et al. Single-synapse analyses of Alzheimer’s disease implicate pathologic tau, DJ1, CD47, and ApoE. Sci Adv. 2021;7:eabk0473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tansey MG, Romero-Ramos M. Immune system responses in Parkinson’s disease: Early and dynamic. Eur J Neurosci. 2019;49:364–83.

Article  PubMed  Google Scholar 

Hirsch EC, Standaert DG. Ten unsolved questions about neuroinflammation in Parkinson’s disease. Mov Disord. 2021;36:16–24.

Article  PubMed  Google Scholar 

Pajares M, I. Rojo A, Manda G, Boscá L, Cuadrado A. Inflammation in Parkinson’s disease: mechanisms and therapeutic implications. Cells. 2020;9:1687.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V. Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol. 2022;22:657–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tan E-K, Chao Y-X, West A, Chan L-L, Poewe W, Jankovic J. Parkinson disease and the immune system — associations, mechanisms and therapeutics. Nat Rev Neurol. 2020;16:303–18.

Article  PubMed  Google Scholar 

Harms AS, Ferreira SA, Romero-Ramos M. Periphery and brain, innate and adaptive immunity in Parkinson’s disease. Acta Neuropathol (Berl). 2021;141:527–45.

Article  CAS  PubMed  Google Scholar 

Harms AS, Yang Y-T, Tansey MG. Central and peripheral innate and adaptive immunity in Parkinson’s disease. Sci Transl Med. 2023;15:eadk3225.

Article  CAS  PubMed  Google Scholar 

Gate D, Saligrama N, Leventhal O, Yang AC, Unger MS, Middeldorp J, et al. Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature. 2020;577:399–404.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rocha NP, Assis F, Scalzo PL, Vieira ÉLM, Barbosa IG, de Souza MS, et al. Reduced Activated T Lymphocytes (CD4+CD25+) and Plasma Levels of Cytokines in Parkinson’s Disease. Mol Neurobiol. 2018;55:1488–97.

Article  CAS  PubMed  Google Scholar 

Cen L, Yang C, Huang S, Zhou M, Tang X, Li K, et al. Peripheral lymphocyte subsets as a marker of Parkinson’s disease in a Chinese population. Neurosci Bull. 2017;33:493–500.

Article  PubMed  PubMed Central  Google Scholar 

Niwa F, Kuriyama N, Nakagawa M, Imanishi J. Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson’s disease. Geriatr Gerontol Int. 2012;12:102–7.

Article  PubMed  Google Scholar 

Chen Y, Qi B, Xu W, Ma B, Li L, Chen Q, et al. Clinical correlation of peripheral CD4+-cell sub-sets, their imbalance and Parkinson’s disease. Mol Med Rep. 2015;12:6105–11.

Article  CAS  PubMed  Google Scholar 

Kustrimovic N, Rasini E, Legnaro M, Marino F, Cosentino M. Expression of dopaminergic receptors on human CD4+ T lymphocytes: flow cytometric analysis of naive and memory subsets and relevance for the neuroimmunology of neurodegenerative disease. J Neuroimmune Pharmacol. 2014;9:302–12.

Article  PubMed  Google Scholar 

Su Y, Shi C, Wang T, Liu C, Yang J, Zhang S, et al. Dysregulation of peripheral monocytes and pro-inflammation of alpha-synuclein in Parkinson’s disease. J Neurol. 2022;269:6386–94.

Article  CAS  PubMed  Google Scholar 

Hasegawa Y, Inagaki T, Sawada M, Suzumura A. Impaired cytokine production by peripheral blood mononuclear cells and monocytes/macrophages in Parkinson’s disease. Acta Neurol Scand. 2000;101:159–64.

Article  CAS  PubMed  Google Scholar 

Bessler H, Djaldetti R, Salman H, Bergman M, Djaldetti M. IL-1β, IL-2, IL-6 and TNF-α production by peripheral blood mononuclear cells from patients with Parkinson’s disease. Biomed Pharmacother. 1999;53:141–5.

Article  CAS  PubMed  Google Scholar 

Reale M, Iarlori C, Thomas A, Gambi D, Perfetti B, Di Nicola M, et al. Peripheral cytokines profile in Parkinson’s disease. Brain Behav Immun. 2009;23:55–63.

Article  CAS  PubMed  Google Scholar 

Li Y, Yang Y, Zhao A, Luo N, Niu M, Kang W, et al. Parkinson’s disease peripheral immune biomarker profile: a multicentre, cross-sectional and longitudinal study. J Neuroinflammation. 2022;19:116.

Article  PubMed  PubMed Central  Google Scholar 

Phongpreecha T, Fernandez R, Mrdjen D, Culos A, Gajera CR, Wawro AM, et al. Single-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases. Sci Adv. 2020;6:eabd5575.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grayson JM, Short SM, Lee CJ, Park N, Marsac C, Sette A, et al. T cell exhaustion is associated with cognitive status and amyloid accumulation in Alzheimer’s disease. Sci Rep. 2023;13:15779.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández Zapata C, Giacomello G, Spruth EJ, Middeldorp J, Gallaccio G, Dehlinger A, et al. Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease. Nat Commun. 2022;13:7210.

Article  PubMed  PubMed Central  Google Scholar 

Fiala M, Lin J, Ringman J, Kermani-Arab V, Tsao G, Patel A, et al. Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2005;7:221–32.

Article  CAS  PubMed  Google Scholar 

Vasantharekha R, Priyanka HP, Nair RS, Hima L, Pratap UP, Srinivasan AV, et al. Alterations in immune responses are associated with dysfunctional intracellular signaling in peripheral blood mononuclear cells of men and women with mild cognitive impairment and Alzheimer’s disease. Mol Neurobiol. 2023 [cited 2023 Dec 20].https://doi.org/10.1007/s12035-023-03764-3

Cook DA, Kannarkat GT, Cintron AF, Butkovich LM, Fraser KB, Chang J, et al. LRRK2 levels in immune cells are increased in Parkinson’s disease. Npj Park Dis. 2017;3:1–12.

Google Scholar 

Gopinath A, Mackie P, Hashimi B, Buchanan AM, Smith AR, Bouchard R, et al. DAT and TH expression marks human Parkinson’s disease in peripheral immune cells. Npj Park Dis. 2022;8:1–14.

Google Scholar 

Jiang S-S, Wang Y-L, Xu Q-H, Gu L-Y, Kang R-Q, Yang W-Y, et al. Cytokine and chemokine map of peripheral specific immune cell subsets in Parkinson’s disease. Npj Park Dis. 2023;9:1–9.

Google Scholar 

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