The impact of sex on metastasis

Wang, Y. et al. Sex disparities in the clinical characteristics, synchronous distant metastasis occurrence and prognosis: a pan-cancer analysis. J. Cancer 12, 498–507 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Kaneko, S. & Li, X. X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism. Sci. Adv. https://doi.org/10.1126/sciadv.aar5598 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Liu, Q. et al. Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation. Nat. Commun. 15, 1148 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kong, N. et al. Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer. Proc. Natl Acad. Sci. USA 119, e2112696119 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, J. et al. Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature 619, 632–639 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwon, H. et al. Androgen conspires with the CD8+ T cell exhaustion program and contributes to sex bias in cancer. Sci. Immunol. 7, 2630 (2022).

Article  Google Scholar 

Tang, J. J. et al. Androgens drive sexual dimorphism in liver metastasis by promoting hepatic accumulation of neutrophils. Cell Rep. 39, 110987 (2022).

Article  CAS  PubMed  Google Scholar 

Hermann, C. D. et al. TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer. J. Exp. Med. 218, e20210911 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ishikawa, K. et al. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320, 661–664 (2008).

Article  CAS  PubMed  Google Scholar 

Fu, A. et al. Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer. Cell 185, 1356–1372.e26 (2022).

Article  CAS  PubMed  Google Scholar 

Pace, F. & Watnick, P. I. The interplay of sex steroids, the immune response, and the intestinal microbiota. Trends Microbiol. 29, 849–859 (2021).

Article  CAS  PubMed  Google Scholar 

Rosiello, G. et al. Sex- and age-related differences in the distribution of bladder cancer metastases. Jpn. J. Clin. Oncol. 51, 976–983 (2021).

Article  PubMed  Google Scholar 

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