Systematic review: genetic polymorphisms in the pharmacokinetics of high-dose methotrexate in pediatric acute lymphoblastic leukemia patients

SEER (2023) Cancer Stat Facts: Childhood Leukemia (Ages 0–19). In: The Surveillance Research Program (SRP) in NCI’s Division of Cancer Control and Population Sciences (DCCPS) [Accessed Januari 2024]

Brown P, Inaba H, Annesley C et al (2020) Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice guidelines in Oncology. J Natl Compr Canc Netw 18:81–112

Article  CAS  PubMed  Google Scholar 

Inaba H, Mullighan CG (2020) Pediatric acute lymphoblastic leukemia. Hematologica 105:2524–2539

Article  CAS  Google Scholar 

Daetwyler E, Bargetzi M, Otth M, Scheinemann K (2022) Late effects of high-dose methotrexate treatment in childhood cancer survivors—a systematic review. BMC Cancer 22:267

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu M, Wu S, Wang Y, Zhao Y, Wang X, Wei C, Liu X, Hao F, Hu C (2022) Association between high-dose methotrexate-induced toxicity and polymorphisms within methotrexate pathway genes in acute lymphoblastic leukemia. Front Pharmacol. https://doi.org/10.3389/fphar.2022.1003812

Article  PubMed  PubMed Central  Google Scholar 

Hamed KM, Dighriri IM, Baomar AF et al (2022) Overview of Methotrexate Toxicity: a Comprehensive Literature Review. Cureus. https://doi.org/10.7759/cureus.29518

Article  PubMed  PubMed Central  Google Scholar 

Moriyama T, Relling MV, Yang JJ (2015) Inherited genetic variation in childhood acute lymphoblastic leukemia. Blood 125:3988–3995

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sajith M, Pawar A, Bafna V, Bartakke S, Subramanian K, Vaidya N (2020) Serum Methotrexate Level and Side effects of High Dose Methotrexate infusion in Pediatric patients with Acute Lymphoblastic Leukemia (ALL). Indian J Hematol Blood Transfus 36:51–58

Article  PubMed  Google Scholar 

Howard SC, McCormick J, Pui C-H, Buddington RK, Harvey RD (2016) Preventing and managing toxicities of high-dose methotrexate. Oncologist 21:1471–1482

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stocco G, Franca R, Verzegnassi F, Londero M, Rabusin M, Decorti G (2013) Pharmacogenomic approaches for tailored anti-leukemic therapy in children. Curr Med Chem 20:2237–2253

Article  CAS  PubMed  Google Scholar 

Chae H, Kim M, Choi SH, Kim S-K, Lee J-W, Chung N-G, Cho B, Kim Y (2020) Influence of plasma methotrexate level and MTHFR genotype in Korean pediatric patients with acute lymphoblastic leukemia. J Chemother 32:251–259

Article  CAS  PubMed  Google Scholar 

Taylor ZL, Thompson LE, Bear H, Mizuno T, Vinks AA, Ramsey LB (2021) Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model. Clin Transl Sci 14:2267–2277

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han J, Liu L, Meng L, Guo H, Zhang J, Han Z-Q, Hong Z-Y (2021) Effect of polymorphisms of ABCB1 and MTHFR on Methotrexate-related toxicities in adults with hematological malignancies. Front Oncol. https://doi.org/10.3389/fonc.2021.759805

Article  PubMed  PubMed Central  Google Scholar 

Ramsey LB, Panetta JC, Smith C et al (2013) Genome-wide study of methotrexate clearance replicates SLCO1B1. Blood 121:898–904

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo Q, Sun J-L, Li R, Li X (2024) Involvement of the ABCB1 C3435T variant but not the MTHFR C677T or MTHFR A1298C variant in high-dose methotrexate-induced toxicity in pediatric acute lymphoblastic leukemia patients in China. Int J Gen Med 17:1221–1231

Article  PubMed  PubMed Central  Google Scholar 

Zhou Y, He H, Ding L, Wang T, Liu X, Zhang M, Zhang A, Fu J (2024) Effects of gene polymorphisms on delayed MTX clearance, toxicity, and metabolomic changes after HD-MTX treatment in children with acute lymphoblastic leukemia. Eur J Pediatr 183:581–590

Article  CAS  PubMed  Google Scholar 

Li M, Kong X-Y, Wang S-M (2023) Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia. Cancer Chemother Pharmacol 91:77–87

Article  CAS  PubMed  Google Scholar 

de Oliveira Henz P, Pinhatti AV, Gregianin LJ, Martins M, Curra M, de Araújo BV, Dalla Costa T (2023) Population pharmacokinetic model of methotrexate in Brazilian pediatric patients with acute lymphoblastic leukemia. Pharm Res 40:1777–1787

Article  PubMed  Google Scholar 

Tan Y, Kong Q, Li X, Tang Y, Mai H, Zhen Z, Zhou D, Chen H (2023) Relationship between methylenetetrahydrofolate reductase gene polymorphisms and methotrexate drug metabolism and toxicity. Transl Pediatr 12:31–45

Article  PubMed  PubMed Central  Google Scholar 

Shen Y, Wang Z, Zhou F, Jin R (2021) The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia. Open Life Sci 16:1203–1212

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng Y, Chen M-H, Zhuang Q, Lin B-J, Chen Y-Y, Yang L, Liu M-B, Que W-C, Qiu H-Q (2021) Genetic factors involved in delayed methotrexate elimination in children with acute lymphoblastic leukemia. Pediatr Blood Cancer 68:28858

Article  Google Scholar 

Schulte RR, Choi L, Utreja N, Van Driest SL, Stein CM, Ho RH (2021) Effect of SLCO1B1 polymorphisms on high-dose methotrexate clearance in children and young adults with leukemia and lymphoblastic lymphoma. Clin Transl Sci 14:343–353

Article  CAS  PubMed  Google Scholar 

Esmaili MA, Kazemi A, Zaker F, Faranoush M, Rezvany MR (2020) Effects of reduced Mir-24 expression on plasma methotrexate levels, therapy-related toxicities, and patient outcomes in pediatric acute lymphoblastic leukemia. Rep Biochem Mol Biol 8:358–365

CAS  PubMed  PubMed Central  Google Scholar 

Kotur N, Lazic J, Ristivojevic B et al (2020) Pharmacogenomic markers of methotrexate response in the consolidation phase of pediatric acute lymphoblastic leukemia treatment. Genes (Basel) 11:468

Article  CAS  PubMed  Google Scholar 

Cwiklinska M, Czogala M, Kwiecinska K et al (2020) Polymorphisms of SLC19A1 80 G > A, MTHFR 677 C > T, and tandem TS repeats influence pharmacokinetics, acute liver toxicity, and vomiting in children with acute lymphoblastic leukemia treated with high doses of methotrexate. Front Pediatr 8:307

Article  PubMed  PubMed Central  Google Scholar 

Razali RH, Noorizhab MNF, Jamari H, James RJ, Teh KH, Ibrahim HM, Teh LK, Salleh MZ (2020) Association of ABCC2 with levels and toxicity of methotrexate in Malaysian childhood Acute Lymphoblastic Leukemia (ALL). Pediatr Hematol Oncol 37:185–197

Article  CAS  PubMed  Google Scholar 

Zhang Y-X, Ma Y, Zhang H, Zhang W-P, Yang X-Y (2020) Genetic polymorphism in MDR1 C3435T is a determinant of methotrexate cerebrospinal fluid concentrations in Chinese children with acute lymphoblastic leukemia. Int J Clin Pharmacol Ther 58:254–260

Article  CAS  PubMed  Google Scholar 

Wang S-M, Kong X-Y, Li M, Sun L-L, Yan D (2020) Association of GGH promoter methylation levels with methotrexate concentrations in Chinese children with acute lymphoblastic leukemia. Pharmacotherapy 40:614–622

Article  CAS  PubMed  Google Scholar 

Mahmoud L, Ben, Mdhaffar M, Frikha R, Ghozzi H, Hakim A, Sahnoun Z, Elloumi M, Zeghal K (2018) Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia. Adv Clin Exp Med 27:1061–1068

Article  PubMed  Google Scholar 

Wang S-M, Zeng W-X, Wu W–S, Sun L-L, Yan D (2018) Association between a microRNA binding site polymorphism in SLCO1A2 and the risk of delayed methotrexate elimination in Chinese children with acute lymphoblastic leukemia. Leuk Res 65:61–66

Article  CAS  PubMed 

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