Ahuja CS, Wilson JR, Nori S, Kotter MRN, Druschel C, Curt A, Fehlings MG. Traumatic spinal cord injury. Nat Rev Dis Primers. 2017;3:17018. https://doi.org/10.1038/nrdp.2017.18. PMID: 28447605.

Jug M, Kejžar N, Cimerman M, Bajrović FF. Window of opportunity for surgical decompression in patients with acute traumatic cervical spinal cord injury. J Neurosurg Spine. 2019;32(5):633–641. doi: 10.3171/2019.10.SPINE19888. PMID: 31881537.

Saadeh YS, Smith BW, Joseph JR, Jaffer SY, Buckingham MJ, Oppenlander ME, Szerlip NJ, Park P. The impact of blood pressure management after spinal cord injury: a systematic review of the literature. Neurosurg Focus. 2017;43(5):E20. https://doi.org/10.3171/2017.8.FOCUS17428. PMID: 29088944.

Wilson JR, Cadotte DW, Fehlings MG. Clinical predictors of neurological outcome, functional status, and survival after traumatic spinal cord injury: a systematic review. J Neurosurg Spine. 2012;17(1 Suppl):11–26. https://doi.org/10.3171/2012.4.AOSPINE1245. PMID: 22985366.

Fehlings MG, Tetreault LA, Wilson JR, Aarabi B, Anderson P, Arnold PM, Brodke DS, Burns AS, Chiba K, Dettori JR, Furlan JC, Hawryluk G, Holly LT, Howley S, Jeji T, Kalsi-Ryan S, Kotter M, Kurpad S, Marino RJ, Martin AR, Massicotte E, Merli G, Middleton JW, Nakashima H, Nagoshi N, Palmieri K, Singh A, Skelly AC, Tsai EC, Vaccaro A, Yee A, Harrop JS. A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury and Central Cord Syndrome: Recommendations on the Timing (≤ 24 Hours Versus > 24 Hours) of Decompressive Surgery. Global Spine J. 2017;7(3 Suppl):195S-202S. doi: 10.1177/2192568217706367. Epub 2017 Sep 5. PMID: 29164024; PMCID: PMC5684850.

Fehlings MG, Vaccaro A, Wilson JR, Singh A, Cadotte W, Harrop D, Aarabi JS, Shaffrey B, Dvorak C, Fisher M, Arnold C, Massicotte P, Lewis EM, Rampersaud S. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical timing in Acute spinal cord Injury Study (STASCIS). PLoS ONE. 2012;7(2):e32037. https://doi.org/10.1371/journal.pone.0032037. Epub 2012 Feb 23. PMID: 22384132; PMCID: PMC3285644.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jug M, Kejžar N, Vesel M, Al Mawed S, Dobravec M, Herman S, Bajrović FF. Neurological recovery after traumatic cervical spinal cord Injury is Superior if Surgical Decompression and Instrumented Fusion are performed within 8 hours versus 8 to 24 hours after Injury: a single Center experience. J Neurotrauma. 2015;32(18):1385–92. https://doi.org/10.1089/neu.2014.3767. Epub 2015 Apr 22. PMID: 25658291.

Article  PubMed  Google Scholar 

Grassner L, Wutte C, Klein B, Mach O, Riesner S, Panzer S, Vogel M, Bühren V, Strowitzki M, Vastmans J, Maier D. Early decompression (< 8 h) after traumatic cervical spinal cord Injury improves functional outcome as assessed by spinal cord independence measure after one year. J Neurotrauma. 2016;33(18):1658–66. https://doi.org/10.1089/neu.2015.4325. Epub 2016 May 9. PMID: 27050499.

Article  PubMed  Google Scholar 

Wilson JR, Witiw CD, Badhiwala J, Kwon BK, Fehlings MG, Harrop JS. Early Surgery for Traumatic Spinal Cord Injury: Where Are We Now? Global Spine J. 2020;10(1 Suppl):84S-91S. doi: 10.1177/2192568219877860. Epub 2020 Jan 6. PMID: 31934526; PMCID: PMC6947677.

Hager S, Eberbach H, Lefering R, Hammer TO, Kubosch D, Jäger C, Südkamp NP, Bayer J, TraumaRegister DGU®. Possible advantages of early stabilization of spinal fractures in multiply injured patients with leading thoracic trauma - analysis based on the TraumaRegister DGU®. Scand J Trauma Resusc Emerg Med. 2020;28(1):42. https://doi.org/10.1186/s13049-020-00737-6. PMID: 32448190; PMCID: PMC7245984.

Article  PubMed  PubMed Central  Google Scholar 

Hax J, Teuben M, Halvachizadeh S, Berk T, Scherer J, Jensen KO, Lefering R, Pape HC, Sprengel K, TraumaRegister DGU. Timing of Spinal Surgery in Polytrauma: The Relevance of Injury Severity, Injury Level and Associated Injuries. Global Spine J. 2023 Nov 14:21925682231216082. doi: 10.1177/21925682231216082. Epub ahead of print. PMID: 37963389.

Ter Wengel PV, Martin E, De Witt Hamer PC, Feller RE, van Oortmerssen JAE, van der Gaag NA, Oner FC, Vandertop WP. Impact of early (< 24 h) Surgical decompression on neurological recovery in thoracic spinal cord Injury: a Meta-analysis. J Neurotrauma. 2019;36(18):2609–17. Epub 2019 May 9. PMID: 30816058.

Article  PubMed  Google Scholar 

Fehlings MG, Wilson JR, Cho N. Methylprednisolone for the treatment of acute spinal cord injury: counterpoint. Neurosurgery. 2014;61 Suppl 1:36–42. https://doi.org/10.1227/NEU.0000000000000412. PMID: 25032529.

Martirosyan NL, Feuerstein JS, Theodore N, Cavalcanti DD, Spetzler RF, Preul MC. Blood supply and vascular reactivity of the spinal cord under normal and pathological conditions. J Neurosurg Spine. 2011;15(3):238–51. Epub 2011 Jun 10. PMID: 21663407.

Article  PubMed  Google Scholar 

Hosman AJF, Barbagallo G, The SCI-POEM, Study EC, van de Meent H, Öner FC, De Iure F, Bonavita J, Kreinest M, Lindtner RA, Quraishi NA, Thumbikat P, Bilić V, Reynolds JJ, Belci M, Börcek AÖ, Morris S, Hoffmann C, Signorelli F, Uznov K, van Middendorp JJ. Neurological recovery after early versus delayed surgical decompression for acute traumatic spinal cord injury. Bone Joint J. 2023;105-B(4):400–411. https://doi.org/10.1302/0301-620X.105B4.BJJ-2022-0947.R2. PMID: 36924174.

Haghnegahdar A, Behjat R, Saadat S, Badhiwala J, Farrokhi MR, Niakan A, Eghbal K, Barzideh E, Shahlaee A, Ghaffarpasand F, Ghodsi Z, Vaccaro AR, Sadeghi-Naini M, Fehlings MG, Guest JD, Derakhshan P, Rahimi-Movaghar V. A Randomized Controlled Trial of Early versus Late Surgical decompression for thoracic and thoracolumbar spinal cord Injury in 73 patients. Neurotrauma Rep. 2020;1(1):78–87. https://doi.org/10.1089/neur.2020.0027. PMID: 34223533; PMCID: PMC8240887.

Article  PubMed  PubMed Central  Google Scholar 

Wutte C, Klein B, Becker J, Mach O, Panzer S, Strowitzki M, Maier D, Grassner L. Earlier decompression (< 8 hours) results in Better neurological and functional outcome after traumatic thoracolumbar spinal cord Injury. J Neurotrauma. 2019;36(12):2020–7. https://doi.org/10.1089/neu.2018.6146. Epub 2019 Jan 25. PMID: 30489193.

Article  PubMed  Google Scholar 

Wutte C, Becker J, Klein B, Mach O, Panzer S, Stuby FM, Strowitzki M, Maier D, Thomé C, Grassner L. Early decompression (< 8 hours) improves functional bladder outcome and mobility after traumatic thoracic spinal cord Injury. World Neurosurg. 2020;134:e847–54. Epub 2019 Nov 9. PMID: 31715410.

Article  PubMed  Google Scholar 

Dvorak MF, Noonan VK, Fallah N, Fisher CG, Finkelstein J, Kwon BK, Rivers CS, Ahn H, Paquet J, Tsai EC, Townson A, Attabib N, Bailey CS, Christie SD, Drew B, Fourney DR, Fox R, Hurlbert RJ, Johnson MG, Linassi AG, Parent S, Fehlings MG, RHSCIR Network. The influence of time from injury to surgery on motor recovery and length of hospital stay in acute traumatic spinal cord injury: an observational Canadian cohort study. J Neurotrauma. 2015;32(9):645–54. https://doi.org/10.1089/neu.2014.3632. Epub 2014 Nov 19. PMID: 25333195; PMCID: PMC4410758.

Article  PubMed  PubMed Central  Google Scholar 

Ahuja CS, Badhiwala JH, Fehlings MG. Time is spine: the importance of early intervention for traumatic spinal cord injury. Spinal Cord. 2020;58(9):1037–9. https://doi.org/10.1038/s41393-020-0477-8. Epub 2020 May 11. PMID: 32393795; PMCID: PMC7471096.

Article  PubMed  PubMed Central  Google Scholar 

Saadoun S, Chen S, Papadopoulos MC. Intraspinal pressure and spinal cord perfusion pressure predict neurological outcome after traumatic spinal cord injury. J Neurol Neurosurg Psychiatry. 2017;88(5):452–3. https://doi.org/10.1136/jnnp-2016-314600. Epub 2016 Nov 18. PMID: 27864426.

Article  PubMed  Google Scholar 

Hogg FRA, Kearney S, Zoumprouli A, Papadopoulos MC, Saadoun S. Acute spinal cord Injury: correlations and causal relations between intraspinal pressure, spinal cord perfusion pressure, lactate-to-pyruvate ratio, and Limb Power. Neurocrit Care. 2021;34(1):121–9. https://doi.org/10.1007/s12028-020-00988-2. PMID: 32435965; PMCID: PMC7940162.

Article  CAS  PubMed  Google Scholar 

Yue JK, Winkler EA, Rick JW, Deng H, Partow CP, Upadhyayula PS, Birk HS, Chan AK, Dhall SS. Update on critical care for acute spinal cord injury in the setting of polytrauma. Neurosurg Focus. 2017;43(5):E19. https://doi.org/10.3171/2017.7.FOCUS17396. PMID: 29088951.

Phang I, Zoumprouli A, Papadopoulos MC, Saadoun S. Microdialysis to optimize cord perfusion and drug delivery in spinal cord Injury. Ann Neurol. 2016;80(4):522–31. https://doi.org/10.1002/ana.24750. Epub 2016 Aug 19. PMID: 27463064.

Article  CAS  PubMed  Google Scholar 

Phang I, Zoumprouli A, Saadoun S, Papadopoulos MC. Safety profile and probe placement accuracy of intraspinal pressure monitoring for traumatic spinal cord injury: injured spinal cord pressure evaluation study. J Neurosurg Spine. 2016;25(3):398–405. Epub 2016 Apr 29. PMID: 27129044.

Article  PubMed  Google Scholar 

Phang I, Werndle MC, Saadoun S, Varsos G, Czosnyka M, Zoumprouli A, Papadopoulos MC. Expansion duroplasty improves intraspinal pressure, spinal cord perfusion pressure, and vascular pressure reactivity index in patients with traumatic spinal cord injury: injured spinal cord pressure evaluation study. J Neurotrauma. 2015;32(12):865–74. Epub 2015 May 4. PMID: 25705999; PMCID: PMC4492612.

Article  PubMed  PubMed Central  Google Scholar 

Chen S, Smielewski P, Czosnyka M, Papadopoulos MC, Saadoun S. Continuous monitoring and visualization of Optimum spinal cord perfusion pressure in patients with Acute Cord Injury. J Neurotrauma. 2017;34(21):2941–9. https://doi.org/10.1089/neu.2017.4982. Epub 2017 May 24. PMID: 28351230.

Article  PubMed  Google Scholar 

Fehlings MG, Wilson JR, Tetreault LA, Aarabi B, Anderson P, Arnold PM, Brodke DS, Burns AS, Chiba K, Dettori JR, Furlan JC, Hawryluk G, Holly LT, Howley S, Jeji T, Kalsi-Ryan S, Kotter M, Kurpad S, Kwon BK, Marino RJ, Martin AR, Massicotte E, Merli G, Middleton JW, Nakashima H, Nagoshi N, Palmieri K, Skelly AC, Singh A, Tsai EC, Vaccaro A, Yee A, Harrop JS. A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Use of Methylprednisolone Sodium Succinate. Global Spine J. 2017;7(3 Suppl):203S-211S. doi: 10.1177/2192568217703085. Epub 2017 Sep 5. PMID: 29164025; PMCID: PMC5686915.

Liu Z, Yang Y, He L, Pang M, Luo C, Liu B, Rong L. High-dose methylprednisolone for acute traumatic spinal cord injury: a meta-analysis. Neurology. 2019;93(9):e841–50. https://doi.org/10.1212/WNL.0000000000007998. Epub 2019 Jul 29. PMID: 31358617.

Article  CAS  PubMed  Google Scholar