Research ArticleNeuroscienceStem cells Open Access | 10.1172/JCI168982

Marija Mihailovich,1,2 Pierre-Luc Germain,1,3 Reinald Shyti,1,2 Davide Pozzi,4,5 Roberta Noberini,1 Yansheng Liu,6 Davide Aprile,2,7 Erika Tenderini,1 Flavia Troglio,1,2,7 Sebastiano Trattaro,1,2,7 Sonia Fabris,8 Ummi Ciptasari,9 Marco Tullio Rigoli,1,2,7 Nicolò Caporale,1,2,7 Giuseppe D’Agostino,1 Filippo Mirabella,2 Alessandro Vitriolo,1,2,7 Daniele Capocefalo,2,7 Adrianos Skaros,1,2 Agnese Virginia Franchini,1 Sara Ricciardi,10,11 Ida Biunno,12 Antonino Neri,7,8 Nael Nadif Kasri,9 Tiziana Bonaldi,1,7 Rudolf Aebersold,6 Michela Matteoli,4,5 and Giuseppe Testa1,2,7

1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

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1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

Find articles by Franchini, A. in: JCI | PubMed | Google Scholar

1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

Find articles by Ricciardi, S. in: JCI | PubMed | Google Scholar

1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

Find articles by Biunno, I. in: JCI | PubMed | Google Scholar

1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems Engineering Srl, c/o OpenZone, Bresso, Milan, Italy.

Address correspondence to: Giuseppe Testa, Head of Neurogenomics Research Centre, Testa Group - Neurogenomics Research Centre, Human Technopole, Palazzo Italia, Viale Rita Levi-Montalcini, 1, 20157 Milan, Italy. Phone: 39.0230247166; Email: giuseppe.testa@fht.org.

Authorship note: M Mihailovich, PLG, and RS contributed equally to this work. M Mihailovich and GT are co–senior authors.

Find articles by Neri, A. in: JCI | PubMed | Google Scholar

1European Institute of Oncology (IEO) IRCCS, Milan, Italy.

2Human Technopole, Milan, Italy.

3Computational Neurogenomics, D-HEST Institute for Neuroscience, Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.

4Department of Biomedical Sciences, Humanitas University, Milan, Italy.

5IRCCS Humanitas Research Hospital, Milan, Italy.

6Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.

7Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

8Hematology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

9Department of Cognitive Neurosciences, RadboudUmc, Donders Institute for Brain Cognition and Behaviour, Nijmegen, Netherlands.

10Department of Biosciences, University of Milan, Milan, Italy.

11National Institute of Molecular Genetics, Fondazione Romeo ed Enrica Invernizzi, Milan, Italy.

12Integrated Systems E