Research ArticleTransplantation Open Access | 10.1172/JCI177460

Nana Talvard-Balland,1,2 Lukas M. Braun,1,3 Karen O. Dixon,4,5 Melissa Zwick,1,3 Helena Engel,1 Alina Hartmann,1 Sandra Duquesne,1 Livius Penter,6,7 Geoffroy Andrieux,8 Lukas Rindlisbacher,9 Andrea Acerbis,1 Jule Ehmann,1 Christoph Köllerer,1 Michela Ansuinelli,6,10 Andres Rettig,1 Kevin Moschallski,1 Petya Apostolova,11,12 Tilman Brummer,11,13,14 Anna L. Illert,1,11,15 Markus A. Schramm,16 Yurong Cheng,17 Anna Köttgen,17 Justus Duyster,1 Hans D. Menssen,18 Jerome Ritz,6 Bruce R. Blazar,19 Melanie Boerries,8,11 Annette Schmitt-Gräff,20 Nurefsan Sariipek,21 Peter Van Galen,21 Joerg M. Buescher,22 Nina Cabezas-Wallscheid,22 Heike L. Pahl,1 Erika L. Pearce,12 Robert J. Soiffer,6 Catherine J. Wu,6 Luca Vago,23 Burkhard Becher,9 Natalie Köhler,1,2 Tobias Wertheimer,1,9 Vijay K. Kuchroo,4 and Robert Zeiser1,11,13

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Talvard-Balland, N. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Braun, L. in: JCI | PubMed | Google Scholar |

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Dixon, K. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Zwick, M. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Engel, H. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Hartmann, A. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Duquesne, S. in: JCI | PubMed | Google Scholar |

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Penter, L. in: JCI | PubMed | Google Scholar |

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Andrieux, G. in: JCI | PubMed | Google Scholar |

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Rindlisbacher, L. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Acerbis, A. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Address correspondence to: Robert Zeiser, Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, 79106 Freiburg, Germany. Phone: 49.761.270.34580; Email: robert.zeiser@uniklinik-freiburg.de.

Authorship note: NTB and LMB are co–first authors. NK, TW, VKK, and RZ are co–senior authors.

Find articles by Ehmann, J. in: JCI | PubMed | Google Scholar

1Department of Internal Medicine I, Faculty of Medicine and Medical Center,

2CIBSS–Centre for Integrative Biological Signalling Studies, and

3Faculty of Biology, University of Freiburg, Freiburg, Germany.

4Gene Lay Institute of Immunology and Inflammation, Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

5Department of Biomedicine, University of Basel and University Hospital of Basel, Basel, Switzerland.

6Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.

7Department of Hematology, Oncology, and Tumorimmunology, Campus Virchow Klinikum, Berlin, Charité–Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

8Institute of Medical Bioinformatics and Systems Medicine, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

9Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

10Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy

11German Cancer Consortium (DKTK) Partner Site Freiburg, a partnership between German Cancer Research Center (DKFZ) and Medical Center, University of Freiburg, Freiburg, Germany.

12The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

13Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.

14Institute of Molecular Medicine and Cell Research (IMMZ), Freiburg, Germany.

15Department of Internal Medicine III, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.

16Department of Rheumatology and Clinical Immunology, Medical Center,

17Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center–University of Freiburg, Freiburg, Germany.

18Novartis Pharma, Basel, Switzerland.

19University of Minnesota, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, Minneapolis, Minnesota, USA.

20University of Freiburg, Freiburg, Germany.

21Division of Hematology, Brigham and Women’s Hospital, Boston, Massachusetts, USA.

22Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

23Unit of Immunogenetics, Leukemia Genomics and Immunobiology, Division of Immunology, Transplantation and Infectious Disease, IRCCS San Raffaele Scientific Institute, Milano