Rewiring the brain: Inflammation’s impact on glutamate and neural networks in depression

Haroon E, Miller AH, Sanacora G. Inflammation, Glutamate, and Glia: A trio of trouble in mood disorders. Neuropsychopharmacology. 2017;42:193–215.

Article  CAS  PubMed  Google Scholar 

Haroon E, Woolwine BJ, Chen X, Pace TW, Parekh S, Spivey JR, et al. IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacology. 2014;39:1777–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haroon E, Felger JC, Woolwine BJ, Chen X, Parekh S, Spivey JR, et al. Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings. Brain Behav Immun. 2015;46:17–22.

Article  CAS  PubMed  Google Scholar 

Haroon E, Fleischer CC, Felger JC, Chen X, Woolwine BJ, Patel T, et al. Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression. Mol Psychiatry. 2016;21:1351–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Beltran DJ, Tsygankova VD, Woolwine BJ, Patel T, Baer W, et al. Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression. Transl Psychiatry. 2021;11:456.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haroon E, Chen X, Li Z, Patel T, Woolwine BJ, Hu XP, et al. Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia. Transl Psychiatry. 2018;8:189.

Article  PubMed  PubMed Central  Google Scholar 

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