Allis, C. D. & Jenuwein, T. The molecular hallmarks of epigenetic control. Nat. Rev. Genet. 17, 487–500 (2016).
Article CAS PubMed Google Scholar
Mashtalir, N. et al. A structural model of the endogenous human BAF complex informs disease mechanisms. Cell 183, 802–817 (2020).
Article CAS PubMed PubMed Central Google Scholar
Hanahan, D. Hallmarks of cancer: new dimensions. Cancer Discov. 12, 31–46 (2022).
Article CAS PubMed Google Scholar
Lai, W. K. M. & Pugh, B. F. Understanding nucleosome dynamics and their links to gene expression and DNA replication. Nat. Rev. Mol. Cell Biol. 18, 548–562 (2017).
Article CAS PubMed PubMed Central Google Scholar
Mittal, P. & Roberts, C. W. M. The SWI/SNF complex in cancer—biology, biomarkers and therapy. Nat. Rev. Clin. Oncol. 17, 435–448 (2020).
Article CAS PubMed PubMed Central Google Scholar
Cramer, P. Organization and regulation of gene transcription. Nature 573, 45–54 (2019).
Article CAS PubMed Google Scholar
Chi, P., Allis, C. D. & Wang, G. G. Covalent histone modifications—miswritten, misinterpreted and mis-erased in human cancers. Nat. Rev. Cancer 10, 457–469 (2010).
Article CAS PubMed PubMed Central Google Scholar
Conery, A. R., Rocnik, J. L. & Trojer, P. Small molecule targeting of chromatin writers in cancer. Nat. Chem. Biol. 18, 124–133 (2022).
Article CAS PubMed Google Scholar
Tsherniak, A. et al. Defining a cancer dependency map. Cell 170, 564–576 (2017).
Article CAS PubMed PubMed Central Google Scholar
Dharia, N. V. et al. A first-generation pediatric cancer dependency map. Nat. Genet. 53, 529–538 (2021).
Article CAS PubMed PubMed Central Google Scholar
Lyko, F. The DNA methyltransferase family: a versatile toolkit for epigenetic regulation. Nat. Rev. Genet. 19, 81–92 (2018).
Article CAS PubMed Google Scholar
Baylin, S. B. & Jones, P. A. Epigenetic determinants of cancer. Cold Spring Harb. Perspect. Biol. https://doi.org/10.1101/cshperspect.a019505 (2016).
Article PubMed PubMed Central Google Scholar
Whittaker, S. J. et al. Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. J. Clin. Oncol. 28, 4485–4491 (2010).
Article CAS PubMed Google Scholar
O’Connor, O. A. et al. Belinostat in patients with relapsed or refractory peripheral T-cell lymphoma: results of the pivotal phase II BELIEF (CLN-19) study. J. Clin. Oncol. 33, 2492–2499 (2015).
Article PubMed PubMed Central Google Scholar
San-Miguel, J. F. et al. Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial. Lancet Haematol. 3, e506–e515 (2016).
Eckschlager, T., Plch, J., Stiborova, M. & Hrabeta, J. Histone deacetylase inhibitors as anticancer drugs. Int. J. Mol. Sci. https://doi.org/10.3390/ijms18071414 (2017).
Article PubMed PubMed Central Google Scholar
Lechner, S. et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat. Chem. Biol. 18, 812–820 (2022).
Article CAS PubMed PubMed Central Google Scholar
Najm, F. J. et al. Chromatin complex dependencies reveal targeting opportunities in leukemia. Nat. Commun. 14, 448 (2023).
Article CAS PubMed PubMed Central Google Scholar
Zhang, Y. et al. Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities. Nat. Struct. Mol. Biol. 30, 1160–1171 (2023).
Article CAS PubMed PubMed Central Google Scholar
Chang, L., Ruiz, P., Ito, T. & Sellers, W. R. Targeting pan-essential genes in cancer: challenges and opportunities. Cancer Cell 39, 466–479 (2021).
Article CAS PubMed PubMed Central Google Scholar
Yang, Z. et al. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell 19, 535–545 (2005).
Article CAS PubMed Google Scholar
Delmore, J. E. et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146, 904–917 (2011).
Article CAS PubMed PubMed Central Google Scholar
Puissant, A. et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 3, 308–323 (2013).
Article CAS PubMed PubMed Central Google Scholar
Hensel, T. et al. Targeting the EWS–ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma. Oncotarget 7, 1451–1463 (2016).
Filippakopoulos, P. et al. Selective inhibition of BET bromodomains. Nature 468, 1067–1073 (2010).
Article CAS PubMed PubMed Central Google Scholar
Dawson, M. A. et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478, 529–533 (2011).
Article CAS PubMed PubMed Central Google Scholar
Doroshow, D. B., Eder, J. P. & LoRusso, P. M. BET inhibitors: a novel epigenetic approach. Ann. Oncol. 28, 1776–1787 (2017).
Article CAS PubMed Google Scholar
Piha-Paul, S. A. et al. Phase 1 study of molibresib (GSK525762), a bromodomain and extra-terminal domain protein inhibitor, in NUT carcinoma and other solid tumors. JNCI Cancer Spectr. 4, pkz093 (2020).
Stathis, A. et al. Clinical response of carcinomas harboring the BRD4–NUT oncoprotein to the targeted bromodomain inhibitor OTX015/MK-8628. Cancer Discov. 6, 492–500 (2016).
Article CAS PubMed PubMed Central Google Scholar
Shorstova, T., Foulkes, W. D. & Witcher, M. Achieving clinical success with BET inhibitors as anti-cancer agents. Br. J. Cancer 124, 1478–1490 (2021).
留言 (0)