Drugs Targeting Cough Receptors: New Therapeutic Options in Refractory or Unexplained Chronic Cough

Morice AH, Millqvist E, Bieksiene K, Birring SS, Dicpinigaitis P, Domingo Ribas C, Hilton Boon M, Kantar A, Lai K, McGarvey L, Rigau D, Satia I, Smith J, Song WJ, Tonia T, van den Berg JWK, van Manen MJG, Zacharasiewicz A. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J. 2020;55(1):1901136.

Article  CAS  PubMed  Google Scholar 

Song WJ, Chang YS, Faruqi S, Kim JY, Kang MG, Kim S, Jo EJ, Kim MH, Plevkova J, Park HW, Cho SH, Morice AH. The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur Respir J. 2015;45(5):1479–81.

Article  PubMed  Google Scholar 

Meltzer EO, Zeiger RS, Dicpinigaitis P, Bernstein JA, Oppenheimer JJ, Way NA, Li VW, Boggs R, Doane MJ, Urdaneta E, Weaver JP, Schelfhout J, Fonseca E. Prevalence and burden of chronic cough in the United States. J Allergy Clin Immunol Pract. 2021;9(11):4037–44 (e4032).

Article  PubMed  Google Scholar 

Domínguez-Ortega J, Plaza V, Li VW, Fonseca E, Cea-Calvo L, Martin A, Sánchez-Jareño M, Brady JE, Schelfhout J. Prevalence of chronic cough and patient characteristics in adults in Spain: a population-based cross-sectional survey. Chron Respir Dis. 2022;19:14799731221098722.

Article  PubMed  PubMed Central  Google Scholar 

Guilleminault L, Li VW, Fonseca E, Martin A, Schelfhout J, Ding H, Le Moine G. Prevalence and burden of chronic cough in France. ERJ Open Res. 2024;10(2):00806.

Article  PubMed  PubMed Central  Google Scholar 

Morice A, Dicpinigaitis P, McGarvey L, Birring SS. Chronic cough: new insights and future prospects. Eur Respir Rev. 2021;30(162):210127.

Article  PubMed  PubMed Central  Google Scholar 

Wallace DV. Evaluation and management of chronic cough in adults. Allergy Asthma Proc. 2023;44(6):382–94.

Article  CAS  PubMed  Google Scholar 

French CL, Irwin RS, Curley FJ, Krikorian CJ. Impact of chronic cough on quality of life. Arch Intern Med. 1998;158(15):1657–61.

Article  CAS  PubMed  Google Scholar 

Bali V, Adriano A, Byrne A, Akers KG, Frederickson A, Schelfhout J. Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life. Qual Life Res Int J Qual Life Asp Treat Care Rehabilit. 2023;33:903–16.

Google Scholar 

Chung KF, McGarvey L, Song WJ, Chang AB, Lai K, Canning BJ, Birring SS, Smith JA, Mazzone SB. Cough hypersensitivity and chronic cough. Nat Rev Dis Primers. 2022;8(1):45.

Article  PubMed  PubMed Central  Google Scholar 

Ryan NM, Vertigan AE, Birring SS. An update and systematic review on drug therapies for the treatment of refractory chronic cough. Expert Opin Pharmacother. 2018;19(7):687–711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeyakumar A, Brickman TM, Haben M. Effectiveness of amitriptyline versus cough suppressants in the treatment of chronic cough resulting from postviral vagal neuropathy. Laryngoscope. 2006;116(12):2108–12.

Article  CAS  PubMed  Google Scholar 

Ryan NM, Birring SS, Gibson PG. Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial. Lancet. 2012;380(9853):1583–9.

Article  CAS  PubMed  Google Scholar 

Vertigan AE, Kapela SL, Ryan NM, Birring SS, McElduff P, Gibson PG. Pregabalin and speech pathology combination therapy for refractory chronic cough: a randomized controlled trial. Chest. 2016;149(3):639–48.

Article  PubMed  Google Scholar 

Morice AH, Menon MS, Mulrennan SA, Everett CF, Wright C, Jackson J, Thompson R. Opiate therapy in chronic cough. Am J Respir Crit Care Med. 2007;175(4):312–5.

Article  CAS  PubMed  Google Scholar 

Morice AH, Millqvist E, Belvisi MG, Bieksiene K, Birring SS, Chung KF, Dal Negro RW, Dicpinigaitis P, Kantar A, McGarvey LP, Pacheco A, Sakalauskas R, Smith JA. Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. Eur Respir J. 2014;44(5):1132–48.

Article  PubMed  Google Scholar 

Parker SM, Smith JA, Birring SS, Chamberlain-Mitchell S, Gruffydd-Jones K, Haines J, Hennessey S, McGarvey LP, Marsden P, Martin MJ, Morice A, O’Hara J, Thomas M. British Thoracic Society Clinical Statement on chronic cough in adults. Thorax. 2023;78(Suppl 6):s3–19.

Article  PubMed  Google Scholar 

Cho PSP, Fletcher HV, Turner RD, Jolley CJ, Birring SS. Impaired cough suppression in chronic refractory cough. Eur Respir J. 2019;53(5):1802203.

Article  CAS  PubMed  Google Scholar 

Hilton E, Satia I, Holt K, Woodcock AA, Belcher J, Smith JA. The effect of pain conditioning on experimentally evoked cough: evidence of impaired endogenous inhibitory control mechanisms in refractory chronic cough. Eur Respir J. 2020;56:2001387.

Article  Google Scholar 

Ando A, Smallwood D, McMahon M, Irving L, Mazzone SB, Farrell MJ. Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control. Thorax. 2016;71(4):323–9.

Article  PubMed  Google Scholar 

Mazzone SB. Neurobiology of coughing in children. J Clin Med. 2023;12(23):7285.

Article  PubMed  PubMed Central  Google Scholar 

Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ. Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol. 2004;557(Pt 2):543–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chou YL, Mori N, Canning BJ. Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs. Am J Physiol Regul Integr Comp Physiol. 2018;314(3):R489-r498.

Article  PubMed  Google Scholar 

Shannon R, Baekey DM, Morris KF, Nuding SC, Segers LS, Lindsey BG. Production of reflex cough by brainstem respiratory networks. Pulm Pharmacol Ther. 2004;17(6):369–76.

Article  CAS  PubMed  Google Scholar 

Farrell MJ, Cole LJ, Chiapoco D, Egan GF, Mazzone SB. Neural correlates coding stimulus level and perception of capsaicin-evoked urge-to-cough in humans. Neuroimage. 2012;61(4):1324–35.

Article  PubMed  Google Scholar 

Driessen AK, Farrell MJ, Mazzone SB, McGovern AE. Multiple neural circuits mediating airway sensations: recent advances in the neurobiology of the urge-to-cough. Respir Physiol Neurobiol. 2016;226:115–20.

Article  PubMed  Google Scholar 

Davenport PW. Clinical cough I: the urge-to-cough: a respiratory sensation. Handb Exp Pharmacol. 2009;187:263–76.

Article  Google Scholar 

Chamberlain Mitchell SA, Garrod R, Clark L, Douiri A, Parker SM, Ellis J, Fowler SJ, Ludlow S, Hull JH, Chung KF, Lee KK, Bellas H, Pandyan A, Birring SS. Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial. Thorax. 2017;72(2):129–36.

Article  PubMed  Google Scholar 

Mazzone SB, Undem BJ. Vagal afferent innervation of the airways in health and disease. Physiol Rev. 2016;96(3):975–1024.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patil MJ, Sun H, Ru F, Meeker S, Undem BJ. Targeting C-fibers for peripheral acting anti-tussive drugs. Pulm Pharmacol Ther. 2019;56:15–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kollarik M, Undem BJ. Sensory transduction in cough-associated nerves. Respir Physiol Neurobiol. 2006;152(3):243–54.

Article  PubMed  Google Scholar 

Jurcakova D, Ru F, Kollarik M, Sun H, Krajewski J, Undem BJ. Voltage-gated sodium channels regulating action potential generation in itch-, nociceptive-, and low-threshold mechanosensitive cutaneous C-fibers. Mol Pharmacol. 2018;94(3):1047–56.

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