Novel developments in the study of estrogen in the pathogenesis and therapeutic intervention of lymphangioleiomyomatosis

Yu J, Parkhitko A, Henske EP. Autophagy: an Achilles heel of tumorigenesis in TSC and LAM. Autophagy. 2011;7:1400–1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu X, Yu JJ, Ilter D, Blenis N, Henske EP, Blenis J. Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proc Natl Acad Sci U S A. 2013;110:14960–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Zhou X, Sun Y, Zhang E, Mancini JD, Parkhitko A, et al. Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2013;49:135–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu JJ, Robb VA, Morrison TA, Ariazi EA, Karbowniczek M, Astrinidis A, et al. Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proc Natl Acad Sci USA. 2009;106:2635–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, Liu X, Zhang E, Kopras EJ, Smith EP, Astreinidis A et al. Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. Agoulnik IU, editor. PLoS ONE. 2020;15:e0228894.

Glassberg MK, Elliot SJ, Fritz J, Catanuto P, Potier M, Donahue R, et al. Activation of the estrogen receptor contributes to the progression of pulmonary lymphangioleiomyomatosis via matrix metalloproteinase-induced cell invasiveness. J Clin Endocrinol Metabolism. 2008;93:1625–33.

Article  CAS  Google Scholar 

Moses MA, Harper J, Folkman J. Doxycycline treatment for lymphangioleiomyomatosis with urinary monitoring for MMPs. N Engl J Med. 2006;354:2621–2.

Article  CAS  PubMed  Google Scholar 

Sun Y, Gu X, Zhang E, Park M-A, Pereira AM, Wang S, et al. Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of akt in mTORC1 hyperactive cells. Cell Death Dis. 2014;5:e1231–1231.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minor BMN, LeMoine D, Seger C, Gibbons E, Koudouovoh J, Taya M, et al. Estradiol augments tumor-induced neutrophil production to promote tumor cell actions in lymphangioleiomyomatosis models. Endocrinology. 2023;164:bqad061.

Article  PubMed  PubMed Central  Google Scholar 

Spanheimer PM, Park J-M, Askeland RW, Kulak MV, Woodfield GW, De Andrade JP, et al. Inhibition of RET increases the efficacy of antiestrogen and is a novel treatment strategy for luminal breast cancer. Clin Cancer Res. 2014;20:2115–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitchell AL, Parisi MA, Sybert AVP. Effects of pregnancy on the renal and pulmonary manifestations in women with tuberous sclerosis complex. Genet Sci. 2003;5:154–60.

Google Scholar 

Urban T, Lazor R, Lacronique J, Murris M, Labrune S, Valeyre D. Pulmonary lymphangioleiomyomatosis: a study of 69 patients. Medicine. 1999;78:321–37.

Article  CAS  PubMed  Google Scholar 

Johnson SR. Clinical experience of lymphangioleiomyomatosis in the UK. Thorax. 2000;55:1052–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen MM, Freyer AM, Johnson SR. Pregnancy experiences among women with lymphangioleiomyomatosis. Respir Med. 2009;103:766–72.

Article  PubMed  Google Scholar 

Hayashida M, Yasuo M, Hanaoka M, Seyama K, Inoue Y, Tatsumi K, et al. Reductions in pulmonary function detected in patients with lymphangioleiomyomatosis: an analysis of the Japanese national research project on intractable diseases database. Respiratory Invest. 2016;54:193–200.

Article  Google Scholar 

Munshi A, Hyslop AD, Kopras EJ, Gupta N. Spontaneous pneumothoraces during pregnancy in patients with lymphangioleiomyomatosis. Respiratory Invest. 2023;61:632–5.

Article  Google Scholar 

Ryu JH, Moss J, Beck GJ, Lee J-C, Brown KK, Chapman JT, et al. The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment. Am J Respir Crit Care Med. 2006;173:105–11.

Article  PubMed  Google Scholar 

Johnson SR, Cordier JF, Lazor R, Cottin V, Costabel U, Harari S, et al. European respiratory society guidelines for the diagnosis and management of lymphangioleiomyomatosis. Eur Respir J. 2010;35:14–26.

Article  CAS  PubMed  Google Scholar 

Shen L, Xu W, Gao J, Wang J, Huang J, Wang Y, et al. Pregnancy after the diagnosis of lymphangioleiomyomatosis (LAM). Orphanet J Rare Dis. 2021;16:133.

Article  PubMed  PubMed Central  Google Scholar 

Sauter M, Sigl J, Schotten K-J, Günthner-Biller M, Knabl J, Fischereder M. Association of oestrogen-containing contraceptives with pulmonary lymphangioleiomyomatosis in women with tuberous sclerosis complex – findings from a survey. Eur J Contracept Reproductive Health Care. 2014;19:39–44.

Article  CAS  Google Scholar 

Oberstein EM, Fleming LE, Gómez-Marin O, Glassberg MK. Pulmonary lymphangioleiomyomatosis (LAM): examining oral contraceptive pills and the onset of disease. J Women’s Health. 2003;12:81–5.

Article  Google Scholar 

Lara B, Fornet I, Goya M, López F, De Miguel JR, Molina M, et al. Anticoncepción, embarazo y enfermedades respiratorias minoritarias. Arch Bronconeumol. 2012;48:372–8.

Article  PubMed  Google Scholar 

Gupta N, Lee H-S, Young LR, Strange C, Moss J, Singer LG, et al. Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis. Eur Respir J. 2019;53:1802066.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cortinas N, Liu J, Kopras E, Memon H, Burkes R, Gupta N. Impact of age, menopause, and sirolimus on spontaneous pneumothoraces in lymphangioleiomyomatosis. Chest. 2022;162:1324–7.

Article  PubMed  Google Scholar 

Sandrini A, Silverstone E, Yates DH. Menstrual cycle variation of retroperitoneal lymphangioleiomyomas in lymphangioleiomyomatosis: brief communication. Intern Med J. 2011;41:832–5.

Article  CAS  PubMed  Google Scholar 

Banner AS, Carrington CB, Emory WB, Kittle F, Leonard G, Ringus J, et al. Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma. N Engl J Med. 1981;305:204–9.

Article  CAS  PubMed  Google Scholar 

Logan RF, Fawcett IW. Oophorectomy for pulmonary lymphangioleiomyomatosis: a case report. Br J Dis Chest. 1985;79:98–100.

Article  CAS  PubMed  Google Scholar 

Sawicka EH, Morris AJR. A report of two long-surviving cases of pulmonary lymphangioleiomyomatosis and the response to progesterone therapy. Br J Dis Chest. 1985;79:400–6.

Article  CAS  PubMed  Google Scholar 

Bevelaqua FA, Epstein H. Pulmonary lymphangiomyomatosis. Chest. 1985;87:552–3.

Article  CAS  PubMed  Google Scholar 

Brentani MM, Carvalho CRR, Saldiva PH, Pacheco MM, Oshima CTF. Steroid receptors in pulmonary lymphangiomyomatosis. Chest. 1984;85:96–9.

Article  CAS  PubMed  Google Scholar 

Lipton JH, Fong TC, Burgess KR. Miliary pattern as presentation of leiomyomatosis of the lung. Chest. 1987;91:781–2.

Article  CAS  PubMed  Google Scholar 

Dishner W, Cordasco EM, Blackburn J, Demeter S, Levin H, Carey WD. Pulmonary lymphangiomyomatosis. Chest. 1984;85:796–9.

Article  CAS  PubMed  Google Scholar 

Taveira-DaSilva AM, Stylianou MP, Hed

留言 (0)

沒有登入
gif