Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW (2004) Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions. Exp Mol Med 36(1):1–12

Article  PubMed  Google Scholar 

Choueiri TK, Kaelin WG Jr. (2020) Targeting the HIF2-VEGF axis in renal cell carcinoma. Nat Med 26(10):1519–1530

Article  CAS  PubMed  Google Scholar 

Lee SH, Golinska M, Griffiths JR (2021) HIF-1-Independent mechanisms regulating metabolic adaptation in Hypoxic Cancer cells. Cells 10(9):2371

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson P, Ivanov P (2014) tRNA fragments in human health and disease. FEBS Lett 588(23):4297–4304

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu B, Cao J, Wang X, Guo C, Liu Y, Wang T (2021) Deciphering the tRNA-derived small RNAs: origin, development, and future. Cell Death Dis 13(1):24

Article  PubMed  PubMed Central  Google Scholar 

Pliatsika V, Loher P, Telonis AG, Rigoutsos I (2016) MINTbase: a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments. Bioinformatics 32(16):2481–2489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng LL, Xu WL, Liu S et al (2016) tRF2Cancer: a web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers. Nucleic Acids Res 44(W1):W185–193

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Rossi J (2017) Aptamers as targeted therapeutics: current potential and challenges. Nat Rev Drug Discov 16(3):181–202

Article  CAS  PubMed  Google Scholar 

Blanco S, Bandiera R, Popis M et al (2016) Stem cell function and stress response are controlled by protein synthesis. Nature 534(7607):335–340

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pereira M, Ribeiro DR, Pinheiro MM, Ferreira M, Kellner S, Soares AR (2021) M(5)U54 tRNA hypomodification by lack of TRMT2A drives the generation of tRNA-Derived small RNAs. Int J Mol Sci 22(6):2941

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cosentino C, Toivonen S, Diaz Villamil E et al (2018) Pancreatic beta-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. Nucleic Acids Res 46(19):10302–10318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Qi M, Shen B et al (2019) Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs. Nucleic Acids Res 47(5):2533–2545

Article  CAS  PubMed  Google Scholar 

Wang X, Matuszek Z, Huang Y et al (2018) Queuosine modification protects cognate tRNAs against ribonuclease cleavage. RNA 24(10):1305–1313

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vitali P, Kiss T (2019) Cooperative 2’-O-methylation of the wobble cytidine of human elongator tRNA(Met)(CAT) by a nucleolar and a cajal body-specific box C/D RNP. Genes Dev 33(13–14):741–746

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Gu X, Li Y, Huang Y, Ju S (2024) Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers. Genes Dis 11(2):597–613

Article  CAS  PubMed  Google Scholar 

Zeng T, Hua Y, Sun C et al (2020) Relationship between tRNA-derived fragments and human cancers. Int J Cancer 147(11):3007–3018

Article  CAS  PubMed  Google Scholar 

Dhahbi JM (2015) 5’ tRNA halves: the next generation of immune signaling molecules. Front Immunol 6:74

Article  PubMed  PubMed Central  Google Scholar 

Saikia M, Jobava R, Parisien M et al (2014) Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol 34(13):2450–2463

Article  PubMed  PubMed Central  Google Scholar 

Wang BG, Yan LR, Xu Q, Zhong XP (2020) The role of transfer RNA-Derived small RNAs (tsRNAs) in Digestive System tumors. J Cancer 11(24):7237–7245

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Xie Y, Zhang S, Song X, Xiao B, Yan Z (2021) tRNA-derived fragments: mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections. Theranostics 11(1):461–469

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu M, Lu B, Zhang J, Ding J, Liu P, Lu Y (2020) tRNA-derived RNA fragments in cancer: current status and future perspectives. J Hematol Oncol 13(1):121

Article  PubMed  PubMed Central  Google Scholar 

Kumar P, Kuscu C, Dutta A (2016) Biogenesis and function of transfer RNA-Related fragments (tRFs). Trends Biochem Sci 41(8):679–689

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin C, Xu PP, Zhang X et al (2020) Pathological significance of tRNA-derived small RNAs in neurological disorders. Neural Regen Res 15(2):212–221

Article  CAS  PubMed  Google Scholar 

Boskovic A, Bing XY, Kaymak E, Rando OJ (2020) Control of noncoding RNA production and histone levels by a 5’ tRNA fragment. Genes Dev 34(1–2):118–131

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ivanov P, Emara MM, Villen J, Gygi SP, Anderson P (2011) Angiogenin-induced tRNA fragments inhibit translation initiation. Mol Cell 43(4):613–623

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lyons SM, Achorn C, Kedersha NL, Anderson PJ, Ivanov P (2016) YB-1 regulates tiRNA-induced stress granule formation but not translational repression. Nucleic Acids Res 44(14):6949–6960

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamasaki S, Ivanov P, Hu GF, Anderson P (2009) Angiogenin cleaves tRNA and promotes stress-induced translational repression. J Cell Biol 185(1):35–42

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu X, He C, Sang B et al (2022) Transfer RNAs-derived small RNAs and their application potential in multiple diseases. Front Cell Dev Biol 10:954431

Article  PubMed  PubMed Central  Google Scholar 

Cheung N, Mitchell P, Wong TY (2010) Diabetic retinopathy. Lancet 376(9735):124–136

Article  PubMed  Google Scholar