Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies

Ye Y, Ma Y, Zhu J. The future of dry powder inhaled therapy: Promising or discouraging for systemic disorders? Int J Pharm. 2022;614:121457.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tse JY, Koike A, Kadota K, Uchiyama H, Fujimori K, Tozuka Y. Porous particles and novel carrier particles with enhanced penetration for efficient pulmonary delivery of antitubercular drugs. Eur J Pharm Biopharm. 2021;167:116–26.

Article  CAS  PubMed  Google Scholar 

Ali AM, Abo Dena AS, Yacoub MH, El-Sherbiny IM. Exploring the influence of particle shape and air velocity on the flowability in the respiratory tract: a computational fluid dynamics approach. Drug Dev Ind Pharm. 2019;45(7):1149–56.

Article  CAS  PubMed  Google Scholar 

Gaikwad SS, Pathare SR, More MA, Waykhinde NA, Laddha UD, Salunkhe KS, Kshirsagar SJ, Patil SS, Ramteke KH. Dry Powder Inhaler with the technical and practical obstacles, and forthcoming platform strategies. J Control Release. 2023;355:292–311.

Article  CAS  PubMed  Google Scholar 

Chaurasiya B, Zhao YY. Dry powder for pulmonary delivery: A comprehensive review. Pharmaceutics. 2021;13(1):1–28.

Google Scholar 

Moon C, Smyth HDC, Watts AB, Williams IIIRO. Delivery Technologies for Orally Inhaled Products: an Update. AAPS PharmSciTech. 2019;20(3):117.

Article  CAS  PubMed  Google Scholar 

Han X, Li D, Reyes-Ortega F, Schneider-Futschik EK. Dry Powder Inhalation for Lung Delivery in Cystic Fibrosis. Pharmaceutics. 2023;15(5):1488.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shukla SK, Sarode A, Kanabar DD, Muth A, Kunda NK, Mitragotri S, Gupta V. Bioinspired particle engineering for non-invasive inhaled drug delivery to the lungs. Mater Sci Eng C. 2021;128:112324.

Clark AR, Weers JG, Dhand R. The Confusing World of Dry Powder Inhalers: It Is All about Inspiratory Pressures, Not Inspiratory Flow Rates. J Aerosol Med Pulm Drug Deliv. 2020;33(1):1–11.

Article  PubMed  PubMed Central  Google Scholar 

Stylianou FS, Angeli SI, Kassinos SC, Svensson M. 10th International symposium on turbulence and shear flow phenomena, TSFP10. Chicago: USA; 2017.

Yao Y, Capecelatro J. Numerical modeling of deagglomeration of cohesive particles by turbulence. AIChE Annual Meet Conf Proc. 2020:261a.

Benke E, Varga P, Szabó-Révész P, Ambrus R. Stability and in vitro aerodynamic studies of inhalation powders containing ciprofloxacin hydrochloride applying different dpi capsule types. Pharm. 2021;13:689.

Pinto JT, Wutscher T, Stankovic-Brandl M, Zellnitz S, Biserni S, Mercandelli A, Kobler M, Buttini F, Andrade L, Daza V, Ecenarro S, Canalejas L, Paudel A. Evaluation of the physico-mechanical properties and electrostatic charging behavior of different capsule types for inhalation under distinct environmental conditions. AAPS PharmSciTech 2020;21(4):128.

Wauthoz N, Hennia I, Ecenarro S, Amighi K. Impact of capsule type on aerodynamic performance of inhalation products: A case study using a formoterol-lactose binary or ternary blend. Int J Pharm. 2018;553(1–2):47–56.

Article  CAS  PubMed  Google Scholar 

Srichana T, Martin GP, Marriott C. Dry powder inhalers: The influence of device resistance and powder formulation on drug and lactose deposition in vitro. Eur J Pharm Sci. 1998;7(1):73–80.

Article  CAS  PubMed  Google Scholar 

Hira D, Koide H, Nakamura S, Okada T, Ishizeki K, Yamaguchi M, Koshiyama S, Oguma T, Ito K, Funayama S, Komase Y, Morita SY, Nishiguchi K, Nakano Y, Terada T. Assessment of inhalation flow patterns of soft mist inhaler co-prescribed with dry powder inhaler using inspiratory flow meter for multi inhalation devices. PLoS One 2018;13(2):e0193082.

Haidl P, Heindl S, Siemon K, Bernacka M, Cloes RM. Inhalation device requirements for patients’ inhalation maneuvers. Respir Med. 2016;118:65–75.

Article  PubMed  Google Scholar 

Pohlmann G, Hohlfeld JM, Haidl P, Pankalla J, Cloes RM. Assessment of the power required for optimal use of current inhalation devices. J Aerosol Med Pulm Drug Deliv. 2018;31(6):339–46.

Article  PubMed  Google Scholar 

Louey MD, Razia S, Stewart PJ. Influence of physico-chemical carrier properties on the in vitro aerosol deposition from interactive mixtures. Int J Pharm. 2003;252(1–2):87–98.

Article  CAS  PubMed  Google Scholar 

Tiano SL, Dalby RN. Comparison of a respiratory suspension aerosolized by an air-jet and an ultrasonic nebulizer. Pharm Dev Technol. 1996;1(3):261–8.

Article  CAS  PubMed  Google Scholar 

Silin N, Tarrio J, Guozden T. An experimental study of the aerodynamic dispersion of loose aggregates in an accelerating flow. Powder Technol. 2017;318:151–61.

Article  CAS  Google Scholar 

Díez F. Capsule-based inhalers: Part I. Manuf Chem. 2019;90(1):42–3.

Google Scholar 

Xiroudaki S, Schoubben A, Giovagnoli S, Rekkas DM. Dry powder inhalers in the digitalization era: current status and future perspectives. Pharm. 2021;13(9):1455.

Díez F, Kalafat J, Bhat J. The science behind capsule-based dry powder inhalation technology. ONdrugDelivery. 2017;2017(80):4–8.

Google Scholar 

Mehta PP. Dry powder inhalers: A concise summary of the electronic monitoring devices. Ther Deliv. 2021;12(1):1–6.

Article  CAS  PubMed  Google Scholar 

Healy AM, Amaro MI, Paluch KJ, Tajber L. Dry powders for oral inhalation free of lactose carrier particles. Adv Drug Del Rev. 2014;75:32–52.

Article  CAS  Google Scholar 

Schuster A, Haliburn C, Döring G, Goldman MH, Group FS. Safety, efficacy and convenience of colistimethate sodium dry powder for inhalation (Colobreathe DPI) in patients with cystic fibrosis: a randomised study. Thorax. 2013;68(4):344–50.

Article  PubMed  Google Scholar 

De Boer AH, Hagedoorn P, Woolhouse R, Wynn E. Computational fluid dynamics (CFD) assisted performance evaluation of the Twincer™ disposable high-dose dry powder inhaler. J Pharm Pharmacol. 2012;64(9):1316–25.

Article  PubMed  Google Scholar 

Hoppentocht M, Akkerman OW, Hagedoorn P, Frijlink HW, De Boer AH. The Cyclops for pulmonary delivery of aminoglycosides; A new member of the Twincer™ family. Eur J Pharm Biopharm. 2015;90:8–15.

Article  CAS  PubMed  Google Scholar 

Friebel C, Steckel H. Single-use disposable dry powder inhalers for pulmonary drug delivery. Expert Opin Drug Deliv. 2010;7(12):1359–72.

Article  CAS  PubMed  Google Scholar 

Jahan N, Archie SR, Shoyaib AA, Kabir N, Cheung K. Recent approaches for solid dose vaccine delivery. Sci Pharm. 2019;87(4):27.

Kanojia G, Have RT, Soema PC, Frijlink H, Amorij JP, Kersten G. Developments in the formulation and delivery of spray dried vaccines. Hum Vaccin Immunother. 2017;13(10):2364–78.

Article  PubMed  PubMed Central  Google Scholar 

Corcoran TE, Venkataramanan R, Hoffman RM, George MP, Petrov A, Richards T, Zhang S, Choi J, Gao YY, Oakum CD, Cook RO, Donahoe M. Systemic delivery of atropine sulfate by the microdose dry-powder inhaler. J Aerosol Med Pulm Drug Deliv. 2013;26(1):46–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Islam N, Cleary MJ. Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery–a review for multidisciplinary researchers. Med Eng Phys. 2012;34(4):409–27.

Article  PubMed  Google Scholar 

Islam N, Gladki E. Dry powder inhalers (DPIs)-A review of device reliability and innovation. Int J Pharm. 2008;360(1–2):1–11.

Article  CAS  PubMed  Google Scholar 

de Boer AH, Hagedoorn P, Hoppentocht M, Buttini F, Grasmeijer F, Frijlink HW. Dry powder inhalation: past, present and future. Expert Opin Drug Deliv. 2017;14(4):499–512.

Article  PubMed  Google Scholar 

Weers JG, Son Y-J, Glusker M, Haynes A, Huang D, Kadrichu N, Le J, Li X, Malcolmson R, Miller DP, Tarara TE, Ung K, Clark A. Idealhalers Versus Realhalers: Is It Possible to Bypass Deposition in the Upper Respiratory Tract? J Aerosol Med Pulm Drug Deliv. 2019;32(2):55–69.

Article  PubMed  Google Scholar 

Byron PR. Prediction of drug residence times in regions of the human respiratory tract following aerosol inhalation. J Pharm Sci. 1986;75(5):433–8.

Article  CAS  PubMed  Google Scholar 

Newman SP, Chan H-K. In VitroIn Vivo Comparisons in Pulmonary Drug Delivery. J Aerosol Med Pulm Drug Deliv. 2008;21(1):77–84.

Article  CAS  PubMed  Google Scholar 

Islam N, Stewart P, Larson I, Hartley P. Effect of carrier size on the dispersion of salmeterol xinafoate from in

留言 (0)

沒有登入
gif