Luo H, Xia X, Huang LB, et al. Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment. Nat Commun. 2022;13(1):6619.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denton AE, Roberts EW, Fearon DT. Stromal cells in the tumor microenvironment. Adv Exp Med Biol. 2018;1060:99–114.

Article  CAS  PubMed  Google Scholar 

Desbois M, Wang Y. Cancer-associated fibroblasts: Key players in shaping the tumor immune microenvironment. Immunol Rev. 2021;302(1):241–58.

Article  CAS  PubMed  Google Scholar 

Khalaf K, Hana D, Chou JT, et al. Aspects of the tumor microenvironment involved in immune resistance and drug resistance. Front Immunol. 2021;12: 656364.

Article  PubMed  PubMed Central  Google Scholar 

Li Z, Sun C, Qin Z. Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming. Theranostics. 2021;11(17):8322–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verginadis II, Avgousti H, Monslow J, et al. A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumor progression. Nat Cell Biol. 2022;24(6):940–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng D, Fu M, Wang M, et al. Targeting TGF-β signal transduction for fibrosis and cancer therapy. Mol Cancer. 2022;21(1):104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lavie D, Ben-Shmuel A, Erez N, et al. Cancer-associated fibroblasts in the single-cell era. Nat Cancer. 2022;3(7):793–807.

Article  PubMed  PubMed Central  Google Scholar 

Mhaidly R, Mechta-Grigoriou F. Fibroblast heterogeneity in tumor microenvironment: role in immunosuppression and new therapies. Semin Immunol. 2020;48: 101417.

Article  CAS  PubMed  Google Scholar 

Mao X, Xu J, Wang W, et al. Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer. 2021;20(1):131.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hutton C, Heider F, Blanco-Gomez A, et al. Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity. Cancer Cell. 2021;39(9):1227–44. https://doi.org/10.1016/j.ccell.2021.06.017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McAndrews KM, Chen Y, Darpolor JK, et al. Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer. Cancer Discov. 2022;12(6):1580–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kieffer Y, Hocine HR, Gentric G, et al. Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. Cancer Discov. 2020;10(9):1330–51.

Article  CAS  PubMed  Google Scholar 

Huang H, Wang Z, Zhang Y, et al. Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell. 2022;40(6):656–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jenkins L, Jungwirth U, Avgustinova A, et al. Cancer-associated fibroblasts suppress CD8+ T-cell infiltration and confer resistance to immune-checkpoint blockade. Cancer Res. 2022;82(16):2904–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foster DS, Januszyk M, Delitto D, et al. Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin. Cancer Cell. 2022;40(11):1392–406.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papageorgis P, Stylianopoulos T. Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review). Int J Oncol. 2015;46(3):933–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang CY, Chung CL, Hu TH, et al. Recent progress in TGF-β inhibitors for cancer therapy. Biomed Pharmacother. 2021;134: 111046.

Article  CAS  PubMed  Google Scholar 

Wen S, Hou Y, Fu L, et al. Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling. Cancer Lett. 2019;442:320–32.

Article  CAS  PubMed  Google Scholar 

Turrell FK, Orha R, Guppy NJ, et al. Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse. Nat Cancer. 2023;4:468–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Itoh G, Takagane K, Fukushi Y, et al. Cancer-associated fibroblasts educate normal fibroblasts to facilitate cancer cell spreading and T-cell suppression. Mol Oncol. 2022;16(1):166–87.

Article  CAS  PubMed  Google Scholar 

Wang B, Zhang S, Tong F, et al. HPV+ HNSCC-derived exosomal miR-9-5p inhibits TGF-β signaling-mediated fibroblast phenotypic transformation through NOX4. Cancer Sci. 2022;113(4):1475–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanley CJ, Mellone M, Ford K, et al. Targeting the myofibroblastic cancer-associated fibroblast phenotype through inhibition of NOX4. J Natl Cancer Inst. 2018;110(1):109–20.

Article  CAS  PubMed  Google Scholar 

Wang SS, Tang XT, Lin M, et al. Perivenous stellate cells are the main source of myofibroblasts and cancer-associated fibroblasts formed after chronic liver injuries. Hepatology. 2021;74(3):1578–94. https://doi.org/10.1002/hep.31848.

Article  CAS  PubMed  Google Scholar 

Kang MK, Jiang F, Kim YJ, et al. CTHRC1 induces pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (myCAFs). Cancers. 2023;15(13):3370. https://doi.org/10.3390/cancers15133370.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan C, Fang Q, Liu P, et al. Mesenchymal stem cells with cancer-associated fibroblast-like phenotype stimulate SDF-1/CXCR4 axis to enhance the growth and invasion of B-cell acute lymphoblastic leukemia cells through cell-to-cell communication. Front Cell Dev Biol. 2021;9: 708513.

Article  PubMed  PubMed Central  Google Scholar 

Wen S, Niu Y, Yeh S, et al. BM-MSCs promote prostate cancer progression via the conversion of normal fibroblasts to cancer-associated fibroblasts. Int J Oncol. 2015;47(2):719–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rubinstein-Achiasaf L, Morein D, Ben-Yaakov H, et al. Persistent inflammatory stimulation drives the conversion of MSCs to inflammatory CAFs that promote pro-metastatic characteristics in breast cancer cells. Cancers. 2021;13(6):1472.

Article  CAS  PubMed  PubMed Central