HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells

Alghanem AF, Wilkinson EL, Emmett MS, Aljasir MA, Holmes K, Rothermel BA, Simms VA, Heath VL, Cross MJ: RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis. 2017;20(3):341–58. https://doi.org/10.1007/s10456-017-9542-0.

Angara K, Borin TF, Arbab AS. Vascular Mimicry: A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma. Transl Oncol. 2017;10(4):650–60. https://doi.org/10.1016/j.tranon.2017.04.007.

Article  PubMed  PubMed Central  Google Scholar 

Armesilla AL, Lorenzo E. Gomez del Arco P, Martinez-Martinez S, Alfranca A, Redondo JM: Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression. Mol Cell Biol. 1999;19(3):2032–43. https://doi.org/10.1128/MCB.19.3.2032.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azzi JR, Sayegh MH, Mallat SG. Calcineurin inhibitors: 40 years later, can’t live without. J Immunol. 2013;191(12):5785–91. https://doi.org/10.4049/jimmunol.1390055.

Article  CAS  PubMed  Google Scholar 

Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 2010;28(17):2817–23. https://doi.org/10.1200/JCO.2009.26.3988.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bengsch B, Wherry EJ. The importance of cooperation: partnerless NFAT induces T cell exhaustion. Immunity. 2015;42(2):203–5. https://doi.org/10.1016/j.immuni.2015.01.023.

Article  CAS  PubMed  Google Scholar 

Buccarelli M, Castellani G, Ricci-Vitiani L: Glioblastoma-Specific Strategies of Vascularization: Implications in Anti-Angiogenic Therapy Resistance. J Pers Med. 2022;12(10). https://doi.org/10.3390/jpm12101625.

Chigurupati S, Venkataraman R, Barrera D, Naganathan A, Madan M, Paul L, Pattisapu JV, Kyriazis GA, Sugaya K, Bushnev S, Lathia JD, Rich JN, Chan SL. Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res. 2010;70(1):418–27. https://doi.org/10.1158/0008-5472.CAN-09-2654.

Article  CAS  PubMed  Google Scholar 

Cui J, Liu X, Dong W, Liu Y, Ruan X, Zhang M, Wang P, Liu L, Xue Y. SNORD17-mediated KAT6B mRNA 2’-O-methylation regulates vasculogenic mimicry in glioblastoma cells. Cell Biol Toxicol. 2023. https://doi.org/10.1007/s10565-023-09805-w.

Article  PubMed  Google Scholar 

Dai S, Zhang J, Huang S, Lou B, Fang B, Ye T, Huang X, Chen B, Zhou M. HNRNPA2B1 regulates the epithelial-mesenchymal transition in pancreatic cancer cells through the ERK/snail signaling pathway. Cancer Cell Int. 2017;17:12. https://doi.org/10.1186/s12935-016-0368-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng J, Chen S, Wang F, Zhao H, Xie Z, Xu Z, Zhang Q, Liang P, Zhai X, Cheng Y. Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion. Growth and Survival Mol Neurobiol. 2016;53(2):1132–44. https://doi.org/10.1007/s12035-014-9080-3.

Article  CAS  PubMed  Google Scholar 

Duncan MC. New directions for the clathrin adaptor AP-1 in cell biology and human disease. Curr Opin Cell Biol. 2022;76: 102079. https://doi.org/10.1016/j.ceb.2022.102079.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Durnian JM, Stewart RM, Tatham R, Batterbury M, Kaye SB. Cyclosporin-A associated malignancy. Clin Ophthalmol. 2007;1(4):421–30.

CAS  PubMed  PubMed Central  Google Scholar 

Ellert-Miklaszewska A, Szymczyk A, Poleszak K, Kaminska B: Delivery of the VIVIT Peptide to Human Glioma Cells to Interfere with Calcineurin-NFAT Signaling. Molecules. 2021;26(16). https://doi.org/10.3390/molecules26164785.

Goshima T, Habara M, Maeda K, Hanaki S, Kato Y, Shimada M. Calcineurin regulates cyclin D1 stability through dephosphorylation at T286. Sci Rep. 2019;9(1):12779. https://doi.org/10.1038/s41598-019-48976-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Graef IA, Chen F, Chen L, Kuo A, Crabtree GR. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001;105(7):863–75. https://doi.org/10.1016/s0092-8674(01)00396-8.

Article  CAS  PubMed  Google Scholar 

Hu L, Liu S, Yao H, Hu Y, Wang Y, Jiang J, Li X, Fu F, Yin Q, Wang H. Identification of a novel heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) ligand that disrupts HnRNPA2B1/nucleic acid interactions to inhibit the MDMX-p53 axis in gastric cancer. Pharmacol Res. 2023;189: 106696. https://doi.org/10.1016/j.phrs.2023.106696.

Article  CAS  PubMed  Google Scholar 

Huang Y, Zhu C, Liu P, Ouyang F, Luo J, Lu C, Tang B, Yang X. L1CAM promotes vasculogenic mimicry formation by miR-143-3p-induced expression of hexokinase 2 in glioma. Mol Oncol. 2023;17(4):664–85. https://doi.org/10.1002/1878-0261.13384.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huelga SC, Vu AQ, Arnold JD, Liang TY, Liu PP, Yan BY, Donohue JP, Shiue L, Hoon S, Brenner S, Ares M Jr, Yeo GW. Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. Cell Rep. 2012;1(2):167–78. https://doi.org/10.1016/j.celrep.2012.02.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jain J, Burgeon E, Badalian TM, Hogan PG, Rao A. A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J Biol Chem. 1995;270(8):4138–45.

Article  CAS  PubMed  Google Scholar 

Jiang X, Xie H, Dou Y, Yuan J, Zeng D, Xiao S. Expression and function of FRA1 protein in tumors. Mol Biol Rep. 2020;47(1):737–52. https://doi.org/10.1007/s11033-019-05123-9.

Article  CAS  PubMed  Google Scholar 

Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol. 2009;27(15):2542–52. https://doi.org/10.1200/JCO.2008.19.9356.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kasim M, Benko E, Winkelmann A, Mrowka R, Staudacher JJ, Persson PB, Scholz H, Meier JC, Fahling M. Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia. J Biol Chem. 2014;289(39):26973–88. https://doi.org/10.1074/jbc.M114.579391.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lapointe S, Perry A, Butowski NA. Primary brain tumours in adults. Lancet. 2018;392(10145):432–46. https://doi.org/10.1016/S0140-6736(18)30990-5.

Article  PubMed  Google Scholar 

Li JH, Liu S, Zhou H, Qu LH, Yang JH: starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res 2014;42(Database issue):D92–7. https://doi.org/10.1093/nar/gkt1248.

Lin Y, Koumba MH, Qu S, Wang D, Lin L. Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition. Cell Signal. 2020;74: 109707. https://doi.org/10.1016/j.cellsig.2020.109707.

Article  CAS  PubMed  Google Scholar 

Lin Z, Xu H, Yang R, Li Z, Zheng H, Zhang Z, Peng J, Zhang X, Qi S, Liu Y, Huang G. Effective treatment of a BRAF V600E-mutant epithelioid glioblastoma patient by vemurafenib: a case report. Anticancer Drugs. 2022;33(1):100–4. https://doi.org/10.1097/CAD.0000000000001130.

Article  CAS  PubMed  Google Scholar 

Liu Y, Shi SL. The roles of hnRNP A2/B1 in RNA biology and disease. Wiley Interdiscip Rev RNA. 2021;12(2): e1612. https://doi.org/10.1002/wrna.1612.

Article  CAS  PubMed  Google Scholar 

Liu XM, Zhang QP, Mu YG, Zhang XH, Sai K, Pang JC, Ng HK, Chen ZP. Clinical significance of vasculogenic mimicry in human gliomas. J Neurooncol. 2011;105(2):173–9. https://doi.org/10.1007/s11060-011-0578-5.

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