Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, et al. Heart disease and stroke statistics—2023 update: a report from the American Heart Association. Circulation. 2023. https://doi.org/10.1161/CIR.0000000000001123.

Article  PubMed  PubMed Central  Google Scholar 

Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol. 2020;76:2982–3021.

Article  PubMed  PubMed Central  Google Scholar 

Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA. The global burden of cardiovascular diseases and risk: a compass for future health. J Am Coll Cardiol. 2022;80:2361–71.

Article  PubMed  Google Scholar 

Wang Z, Ma L, Liu M, Fan J, Hu S, Writing Committee of the Report on Cardiovascular Health and Diseases in China. Summary of the 2022 report on cardiovascular health and diseases in China. Chin Med J (Engl). 2023;136:2899–908.

Article  PubMed  Google Scholar 

Faerch K, Vaag A, Holst JJ, Hansen T, Jørgensen T, Borch-Johnsen K. Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study. Diabetes Care. 2009;32:439–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018;17:122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Chi X, Wang Y, Setrerrahmane S, Xie W, Xu H. Trends in insulin resistance: insights into mechanisms and therapeutic strategy. Signal Transduct Target Ther. 2022;7:216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adeva-Andany MM, Martínez-Rodríguez J, González-Lucán M, Fernández-Fernández C, Castro-Quintela E. Insulin resistance is a cardiovascular risk factor in humans. Diabetes Metab Syndr. 2019;13:1449–55.

Article  PubMed  Google Scholar 

Bornfeldt KE, Tabas I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 2011;14:575–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Otowa-Suematsu N, Sakaguchi K, Kaneko A, Ito J, Morita Y, Miura H, et al. Relation of cardiac function to insulin resistance as evaluated by hyperinsulinemic-euglycemic clamp analysis in individuals with type 2 diabetes. J Diabetes Investig. 2021;12:2197–202.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cersosimo E, Solis-Herrera C, Trautmann ME, Malloy J, Triplitt CL. Assessment of pancreatic β-cell function: review of methods and clinical applications. Curr Diabetes Rev. 2014;10:2–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazidi M, Kengne A-P, Katsiki N, Mikhailidis DP, Banach M. Lipid accumulation product and triglycerides/glucose index are useful predictors of insulin resistance. J Diabetes Complicat. 2018;32:266–70.

Article  Google Scholar 

Lee J, Kim B, Kim W, Ahn C, Choi HY, Kim JG, et al. Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population. Sci Rep. 2021;11:2366.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hong S, Han K, Park C-Y. The triglyceride glucose index is a simple and low-cost marker associated with atherosclerotic cardiovascular disease: a population-based study. BMC Med. 2020;18:361.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu X, Huang R, Lin Y, Guo Y, Xiong Z, Zhong X, et al. High triglyceride-glucose index in young adulthood is associated with incident cardiovascular disease and mortality in later life: insight from the CARDIA study. Cardiovasc Diabetol. 2022;21:155.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang A, Tian X, Zuo Y, Chen S, Meng X, Wu S, et al. Change in triglyceride-glucose index predicts the risk of cardiovascular disease in the general population: a prospective cohort study. Cardiovasc Diabetol. 2021;20:113.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui H, Liu Q, Wu Y, Cao L. Cumulative triglyceride-glucose index is a risk for CVD: a prospective cohort study. Cardiovasc Diabetol. 2022;21:22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dang K, Wang X, Hu J, Zhang Y, Cheng L, Qi X, et al. The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018. Cardiovasc Diabetol. 2024;23:8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Zuo Y, Qian F, Chen S, Tian X, Wang P, et al. Triglyceride-glucose index variability and incident cardiovascular disease: a prospective cohort study. Cardiovasc Diabetol. 2022;21:105.

Article  PubMed  PubMed Central  Google Scholar 

Hao B, Lyu L, Xu J, Zhu X, Xu C, Gao W, et al. The relationship between triglyceride-glucose index and prospective key clinical outcomes in patients hospitalised for coronary artery disease. Cardiovasc Diabetol. 2024;23:40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmed B, Sultana R, Greene MW. Adipose tissue and insulin resistance in obese. Biomed Pharmacother. 2021;137: 111315.

Article  CAS  PubMed  Google Scholar 

Liu L, Peng J, Wang N, Wu Z, Zhang Y, Cui H, et al. Comparison of seven surrogate insulin resistance indexes for prediction of incident coronary heart disease risk: a 10-year prospective cohort study. Front Endocrinol (Lausanne). 2024;15:1290226.

Article  PubMed  Google Scholar 

Park H-M, Han T, Heo S-J, Kwon Y-J. Effectiveness of the triglyceride-glucose index and triglyceride-glucose-related indices in predicting cardiovascular disease in middle-aged and older adults: a prospective cohort study. J Clin Lipidol. 2023;18:e70.

Article  PubMed  Google Scholar 

Miao H, Zhou Z, Yang S, Zhang Y. The association of triglyceride-glucose index and related parameters with hypertension and cardiovascular risk: a cross-sectional study. Hypertens Res. 2023. https://doi.org/10.1038/s41440-023-01502-9.

Article  PubMed  Google Scholar 

Huo R-R, Zhai L, Liao Q, You X-M. Changes in the triglyceride glucose-body mass index estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study. Cardiovasc Diabetol. 2023;22:254.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li F, Wang Y, Shi B, Sun S, Wang S, Pang S, et al. Association between the cumulative average triglyceride glucose-body mass index and cardiovascular disease incidence among the middle-aged and older population: a prospective nationwide cohort study in China. Cardiovasc Diabetol. 2024;23:16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Y, Hu Y, Smith JP, Strauss J, Yang G. Cohort profile: the China health and retirement longitudinal study (CHARLS). Int J Epidemiol. 2014;43:61–8.

Article  PubMed  Google Scholar 

Sinaga KP, Yang M-S. Unsupervised K-means clustering algorithm. IEEE Access. 2020;8:80716–27.

Article  Google Scholar 

Singh A, Yadav A, Rana A. K-means with three different distance metrics. IJCA. 2013;67:13–7.

Article  Google Scholar 

Ma Y-C, Zuo L, Chen J-H, Luo Q, Yu X-Q, Li