Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer’s disease: a randomized, controlled clinical trial

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–46. https://doi.org/10.1016/S0140-6736(20)30367-6. (Epub 2020 Jul 30. Erratum in: Lancet. 2023 Sep 30;402(10408):1132. PMID: 327389 PMCID: PMC7392084).

Article  PubMed  PubMed Central  Google Scholar 

Ornish D, Ornish A. UnDo It. New York: Ballantine Books; 2019.

Google Scholar 

Dhana K, Agarwal P, James BD, Leurgans SE, Rajan KB, Aggarwal NT, Barnes LL, Bennett DA, Schneider JA. Healthy Lifestyle and Cognition in Older Adults With Common Neuropathologies of Dementia. JAMA Neurol. 2024. https://doi.org/10.1001/jamaneurol.2023.5491. Epub ahead of print. PMID: 38315471.

Morris MC, Evans DA, Tangney CC, Bienias JL, Wilson RS. Associations of vegetable and fruit consumption with age-related cognitive change. Neurology. 2006;67(8):1370–6. https://doi.org/10.1212/01.wnl.0000240224.38978.d8. (PMID:17060562;PMCID:PMC3393520).

Article  CAS  PubMed  Google Scholar 

Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Schneider J, Wilson RS. Dietary fats and the risk of incident Alzheimer disease. Arch Neurol. 2003;60(2):194–200. https://doi.org/10.1001/archneur.60.2.194. (Erratum.In:ArchNeurol.2003Aug;60(8):1072 PMID: 12580703).

Article  PubMed  Google Scholar 

Yu JT, Xu W, Tan CC, Andrieu S, Suckling J, Evangelou E, Pan A, Zhang C, Jia J, Feng L, Kua EH, Wang YJ, Wang HF, Tan MS, Li JQ, Hou XH, Wan Y, Tan L, Mok V, Tan L, Dong Q, Touchon J, Gauthier S, Aisen PS, Vellas B. Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020;91(11):1201–9. https://doi.org/10.1136/jnnp-2019-321913. (Epub 2020 Jul 20. PMID: 32690803; PMCID: PMC7569385).

Article  PubMed  Google Scholar 

Blumenthal JA, Smith PJ, Mabe S, Hinderliter A, Lin PH, Liao L, et al. Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial. Neurology. 2019;92(3):e212–23. https://doi.org/10.1212/WNL.0000000000006784. (Epub 2018/12/21. PubMed PMID: 30568005; PubMed Central PMCID: PMCPMC6340382).

Article  PubMed  PubMed Central  Google Scholar 

Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255–63. https://doi.org/10.1016/S0140-6736(15)60461-5. (Epub 2015 Mar 12 PMID: 25771249).

Article  PubMed  Google Scholar 

Rosenberg A, Ngandu T, Rusanen M, Antikainen R, Backman L, Havulinna S, et al. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial. Alzheimers Dement. 2018;14(3):263–70. https://doi.org/10.1016/j.jalz.2017.09.006. (Epub 2017/10/23. PubMed PMID: 29055814).

Article  PubMed  Google Scholar 

Solomon A, Turunen H, Ngandu T, Peltonen M, Levalahti E, Helisalmi S, et al. Effect of the apolipoprotein e genotype on cognitive change during a multidomain lifestyle intervention: a subgroup analysis of a randomized clinical trial. JAMA Neurol. 2018;75(4):462–70. https://doi.org/10.1001/jamaneurol.2017.4365. (Epub 2018/01/23. PubMed PMID: 29356827; PubMed Central PMCID: PMCPMC5885273).

Article  PubMed  PubMed Central  Google Scholar 

Lehtisalo J, Rusanen M, Solomon A, Antikainen R, Laatikainen T, Peltonen M, et al. Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial. Eur Heart J. 2022. https://doi.org/10.1093/eurheartj/ehab922. Epub 2022/01/21. PubMed PMID: 35051281.

Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, et al. World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020;16(7):1078–94. https://doi.org/10.1002/alz.12123. (Epub 2020/07/07. PubMed PMID: 32627328).

Article  PubMed  Google Scholar 

Kivipelto M, Mangialasche F, Snyder H M, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi S H, Chowdhary N, Crivelli L, De La Torre R, Du Y, Dua T, Espeland M, Feldman H H, Hartmanis M, Hartmann T, Heffernan M, Henry C J, Hong C H, Håkansson K, Iwatsubo T, Jeong J H, Jimenez‐Maggiora G, Koo E H, Launer L J, Lehtisalo J, Lopera F, Martínez‐Lage P, Martins R, Middleton L, Molinuevo J L, Montero‐Odasso M, Moon S Y, Morales‐Pérez K, Nitrini R, Nygaard H B, Park Y K, Peltonen M, Qiu C, Quiroz Y T, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas R M, Scheltens P, Sevlever G, Soininen H, Sosa A L, Suemoto C K, Tainta‐Cuezva M, Velilla L, Wang Y, Whitmer R, Xu X, Bain L J, Solomon A, Ngandu T, Carillo, M C. World‐Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimer's Dement. 2020, https://doi.org/10.1002/alz.12123.

Yaffe K, Vittinghoff E, Dublin S, Peltz CB, Fleckenstein LE, Rosenberg DE, Barnes DE, Balderson BH, Larson EB. Effect of personalized risk-reduction strategies on cognition and dementia risk profile among older adults: the SMARRT randomized clinical trial. JAMA Intern Med. 2023:e236279. https://doi.org/10.1001/jamainternmed.2023.6279. Epub ahead of print. PMID: 38010725; PMCID: PMC10682943

Ornish D, Scherwitz LW, Billings JH, Brown SE, Gould KL, Merritt TA, Sparler S, Armstrong WT, Ports TA, Kirkeeide RL, Hogeboom C, Brand RJ. Intensive lifestyle changes for reversal of coronary heart disease. JAMA. 1998;280(23):2001–7. https://doi.org/10.1001/jama.280.23.2001. (Erratum.In:JAMA1999Apr21;281(15):1380 PMID: 9863851).

Article  CAS  PubMed  Google Scholar 

Ornish D, Scherwitz LW, Doody RS, Kesten D, McLanahan SM, Brown SE, DePuey E, Sonnemaker R, Haynes C, Lester J, McAllister GK, Hall RJ, Burdine JA, Gotto AM Jr. Effects of stress management training and dietary changes in treating ischemic heart disease. JAMA. 1983;249(1):54–9 (PMID: 6336794).

Article  CAS  PubMed  Google Scholar 

Gould KL, Ornish D, Scherwitz L, Brown S, Edens RP, Hess MJ, Mullani N, Bolomey L, Dobbs F, Armstrong WT, et al. Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification. JAMA. 1995;274(11):894–901. https://doi.org/10.1001/jama.1995.03530110056036. (PMID: 7674504).

Article  CAS  PubMed  Google Scholar 

Dhana K, Evans DA, Rajan KB, Bennett DA, Morris MC. Healthy lifestyle and the risk of Alzheimer dementia: Findings from 2 longitudinal studies. Neurology. 2020;95(4):e374–83. https://doi.org/10.1212/WNL.0000000000009816. (Epub 2020 Jun 17. PMID: 32554763; PMCID: PMC7455318).

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):263–9. https://doi.org/10.1016/j.jalz.2011.03.005. (Epub 2011 Apr 21. PMID: 21514250; PMCID: PMC3312024).

Article  PubMed  Google Scholar 

Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7:270–9.

Article  PubMed  Google Scholar 

McDonald K, Seltzer E, Lu M, Gaisenband SD, Fletcher C, McLeroth P, Saini KS. Quantifying the impact of the COVID-19 pandemic on clinical trial screening rates over time in 37 countries. Trials. 2023;24(1):254. https://doi.org/10.1186/s13063-023-07277-1. (PMID:37013558;PMCID:PMC10071259).

Article  PubMed  PubMed Central  Google Scholar 

Tang HY, Vitiello MV, Perlis M, Mao JJ, Riegel B. A pilot study of audio-visual stimulation as a self-care treatment for insomnia in adults with insomnia and chronic pain. Appl Psychophysiol Biofeedback. 2014;39(3–4):219–25. https://doi.org/10.1007/s10484-014-9263-8. (PMID:25257144;PMCID:PMC4221414).

Article  PubMed  PubMed Central  Google Scholar 

Horsley K. Unlimited Memory. Granger Indiana: TCK Publishing; 2016.

Google Scholar 

Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Wilson RS, et al. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol. 2003;60(7):940–6. https://doi.org/10.1001/archneur.60.7.940. (Epub 2003/07/23. PubMed PMID: 12873849).

Article  PubMed  Google Scholar 

Voulgaropoulou SD, van Amelsvoort T, Prickaerts J, Vingerhoets C. The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies. Brain Res. 2019;1725:146476. https://doi.org/10.1016/j.brainres.2019.146476. Epub 2019/09/29. PubMedPMID:31560864.

Article  CAS  PubMed  Google Scholar 

Ringman JM, Frautschy SA, Teng E, Begum AN, Bardens J, Beigi M, Gylys KH, Badmaev V, Heath DD, Apostolova LG, Porter V, Vanek Z, Marshall GA, Hellemann G, Sugar C, Masterman DL, Montine TJ, Cummings JL, Cole GM. Oral curcumin for Alzheimer’s disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study. Alzheimers Res Ther. 2012;4(5):43. https://doi.org/10.1186/alzrt146. (PMID:23107780;PMCID:PMC3580400).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shea TB, Remington R. Nutritional supplementation for Alzheimer’s disease? Curr Opin Psychiatry. 2015;28(2):141–7. https://doi.org/10.1097/YCO.0000000000000138. (Epub 2015/01/21. PubMed PMID: 25602242).

Article  PubMed  Google Scholar 

Pradhan N, Singh C, Singh A. Coenzyme Q10 a mitochondrial restorer for various brain disorders. Naunyn Schmiedebergs Arch Pharmacol. 2021;394(11):2197–222. https://doi.org/10.1007/s00210-021-02161-8. (Epub 2021/10/02 PubMed PMID: 34596729).

Article  CAS  PubMed  Google Scholar 

Harrison FE. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer’s disease. J Alzheimers Dis. 2012;29(4):711–26. https://doi.org/10.3233/JAD-2012-111853. (Epub 2012/03/01. PubMed PMID: 22366772; PubMed Central PMCID: PMCPMC3727637).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lauer AA, Grimm HS, Apel B, Golobrodska N, Kruse L, Ratanski E, et al. Mechanistic Link between Vitamin B12 and Alzheimer's Disease. Biomolecules. 2022;12(1). https://doi.org/10.3390/biom12010129. Epub 2022/01/22. PubMed PMID: 35053277; PubMed Central PMCID: PMCPMC8774227.

Du K, Zheng X, Ma ZT, Lv JY, Jiang WJ, Liu MY. Association of Circulating Magnesium Levels in Patients With Alzheimer’s Disease From 1991 to 2021: A Systematic Review and Meta-Analysis. Front Aging Neurosci. 2021;13:799824. https://doi.org/10.3389/fnagi.2021.799824. (Epub 2022/01/28. PubMed PMID: 35082658; PubMed Central P

留言 (0)

沒有登入
gif