Considerations on efforts needed to improve our understanding of the genetics of obesity

Davenport CB. Body build and its inheritance. Proc Natl Acad Sci USA. 1923;9:226–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouchard C. Genetics of obesity: what we have learned over decades of research. Obesity. 2021;29:802–20.

Article  PubMed  Google Scholar 

Bray GA. Beyond BMI. Nutrients. 2023;15:2254.

Article  PubMed  PubMed Central  Google Scholar 

Bouchard C. BMI, fat mass, abdominal adiposity and visceral fat: where is the ‘beef’? Int J Obes. 2007;31:1552–3.

Article  CAS  Google Scholar 

Katzmarzyk PT, Bouchard C. Where is the beef? Waist circumference is more highly correlated with BMI and total body fat than with abdominal visceral fat in children. Int J Obes. 2014;38:753–4.

Article  CAS  Google Scholar 

Agrawal S, Wang M, Klarqvist MDR, Smith K, Shin J, Dashti H, et al. Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots. Nat Commun. 2022;13:3771.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riveros-McKay F, Mistry V, Bounds R, Hendricks A, Keogh JM, Thomas H, et al. Genetic architecture of human thinness compared to severe obesity. PLoS Genet. 2019;15:e1007603.

Article  PubMed  PubMed Central  Google Scholar 

Berndt SI, Gustafsson S, Magi R, Ganna A, Wheeler E, Feitosa MF, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013;45:501–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hinney A, Nguyen TT, Scherag A, Friedel S, Bronner G, Muller TD, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE. 2007;2:e1361.

Article  PubMed  PubMed Central  Google Scholar 

Orthofer M, Valsesia A, Magi R, Wang QP, Kaczanowska J, Kozieradzki I, et al. Identification of ALK in thinness. Cell. 2020;181:1246–62.e22.

Article  CAS  PubMed  Google Scholar 

Scannell Bryan M, Argos M, Pierce B, Tong L, Rakibuz-Zaman M, Ahmed A, et al. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults. PLoS ONE. 2014;9:e105062.

Article  PubMed  PubMed Central  Google Scholar 

Williams PT. Quantile-dependent heritability of computed tomography, dual-energy x-ray absorptiometry, anthropometric, and bioelectrical measures of adiposity. Int J Obes. 2020;44:2101–12.

Article  CAS  Google Scholar 

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316:889–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet. 2007;3:e115.

Article  PubMed  PubMed Central  Google Scholar 

Abdellaoui A, Yengo L, Verweij KJH, Visscher PM. 15 years of GWAS discovery: realizing the promise. Am J Hum Genet. 2023;110:179–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loos RJF, Yeo GSH. The genetics of obesity: from discovery to biology. Nat Rev Genet. 2022;23:120–33.

Article  CAS  PubMed  Google Scholar 

Fernandez-Rhodes L, Graff M, Buchanan VL, Justice AE, Highland HM, Guo X, et al. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—the Hispanic/Latino Anthropometry Consortium. HGG Adv. 2022;3:100099.

CAS  PubMed  PubMed Central  Google Scholar 

Minster RL, Hawley NL, Su CT, Sun G, Kershaw EE, Cheng H, et al. A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nat Genet. 2016;48:1049–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018;50:26–41.

Article  CAS  PubMed  Google Scholar 

Speakman JR, Loos RJF, O’Rahilly S, Hirschhorn JN, Allison DB. GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. Int J Obes. 2018;42:1524–31.

Article  CAS  Google Scholar 

Shungin D, Deng WQ, Varga TV, Luan J, Mihailov E, Metspalu A, et al. Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genet. 2017;13:e1006812.

Article  PubMed  PubMed Central  Google Scholar 

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, et al. The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PLoS Genet. 2015;11:e1005378.

Article  PubMed  PubMed Central  Google Scholar 

Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, et al. Gene x physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet. 2013;9:e1003607.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, et al. Gene x dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet. 2015;24:4728–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bray GA, Bouchard C. The biology of human overfeeding: a systematic review. Obes Rev. 2020;21:e13040.

Article  CAS  PubMed  Google Scholar 

Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, et al. The response to long-term overfeeding in identical twins. N Engl J Med. 1990;322:1477–82.

Article  CAS  PubMed  Google Scholar 

Bouchard C, Tremblay A, Despres JP, Theriault G, Nadeau A, Lupien PJ, et al. The response to exercise with constant energy intake in identical twins. Obes Res. 1994;2:400–10.

Article  CAS  PubMed  Google Scholar 

Hainer V, Stunkard AJ, Kunesova M, Parizkova J, Stich V, Allison DB. Intrapair resemblance in very low calorie diet-induced weight loss in female obese identical twins. Int J Obes Relat Metab Disord. 2000;24:1051–7.

Article  CAS  PubMed  Google Scholar 

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Worheide MA, et al. Mapping the proteo-genomic convergence of human diseases. Science. 2021;374:eabj1541.

Article  PubMed  PubMed Central  Google Scholar 

Garcia LA, Day SE, Coletta RL, Campos B, Benjamin TR, De Filippis E, et al. Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes. Clin Epigenetics. 2021;13:100.

Article  CAS  PubMed  PubMed Central 

留言 (0)

沒有登入
gif