Hackam D, Caplan M. Necrotizing enterocolitis: Pathophysiology from a historical context. Semin Pediatr Surg. 2018;27:11–8.
Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med. 2011;364:255–64.
Article CAS PubMed PubMed Central Google Scholar
Pammi M, Cope J, Tarr PI, Warner BB, Morrow AL, Mai V, et al. Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis. Microbiome. 2017;5:31.
Article PubMed PubMed Central Google Scholar
Battersby AJ, Gibbons DL. The gut mucosal immune system in the neonatal period. Pediatr Allergy Immunol. 2013;24:414–21.
Lueschow SR, McElroy SJ. The Paneth Cell: The Curator and Defender of the Immature Small Intestine. Front Immunol. 2020;11:587.
Article CAS PubMed PubMed Central Google Scholar
Chaaban H, Patel MM, Burge K, Eckert JV, Lupu C, Keshari RS, et al. Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study. Microorganisms. 2022;10:519.
Article CAS PubMed PubMed Central Google Scholar
Nanthakumar N, Meng D, Goldstein AM, Zhu W, Lu L, Uauy R, et al. The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PloS One. 2011;6:e17776.
Article CAS PubMed PubMed Central Google Scholar
Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, et al. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. J Immunol. 2013;190:3541–51.
Article CAS PubMed Google Scholar
Lu P, Sodhi CP, Hackam DJ. Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis. Pathophysiology. 2014;21:81–93.
Article CAS PubMed Google Scholar
Dasgupta S, Arya S, Choudhary S, Jain SK. Amniotic fluid: Source of trophic factors for the developing intestine. World J Gastrointest Pathophysiol. 2016;7:38–47.
Article PubMed PubMed Central Google Scholar
Hirai C, Ichiba H, Saito M, Shintaku H, Yamano T, Kusuda S. Trophic effect of multiple growth factors in amniotic fluid or human milk on cultured human fetal small intestinal cells. J Pediatr Gastroenterol Nutr. 2002;34:524–8.
Carr LE, Virmani MD, Rosa F, Munblit D, Matazel KS, Elolimy AA, et al. Role of Human Milk Bioactives on Infants’ Gut and Immune Health. Front Immunol. 2021;12:604080.
Article CAS PubMed PubMed Central Google Scholar
Lyons KE, Ryan CA, Dempsey EM, Ross RP, Stanton C. Breast Milk, a Source of Beneficial Microbes and Associated Benefits for Infant Health. Nutrients. 2020;12:1039.
Article CAS PubMed PubMed Central Google Scholar
Guo J, Tan M, Zhu J, Tian Y, Liu H, Luo F, et al. Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19. Nutrients. 2022;14:2513.
Article CAS PubMed PubMed Central Google Scholar
Sari RN, Pan J, Zhang W, Li Y, Zhu H, Pang X, et al. Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study. Front Nutr. 2021;8:682429.
Article PubMed PubMed Central Google Scholar
Caplan MS, Underwood MA, Modi N, Patel R, Gordon PV, Sylvester KG, et al. Necrotizing Enterocolitis: Using Regulatory Science and Drug Development to Improve Outcomes. J Pediatrics. 2019;212:208–15.e1.
Kobata R, Tsukahara H, Ohshima Y, Ohta N, Tokuriki S, Tamura S, et al. High levels of growth factors in human breast milk. Early Hum Dev. 2008;84:67–9.
Article CAS PubMed Google Scholar
Tang X, Liu H, Yang S, Li Z, Zhong J, Fang R. Epidermal Growth Factor and Intestinal Barrier Function. Mediators Inflamm. 2016;2016:1927348.
Article PubMed PubMed Central Google Scholar
Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, et al. Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005;288:G755–62.
Article CAS PubMed Google Scholar
Nolan LS, Parks OB, Good M. A Review of the Immunomodulating Components of Maternal Breast Milk and Protection Against Necrotizing Enterocolitis. Nutrients. 2019;12:14.
Article PubMed PubMed Central Google Scholar
Warner BB, Ryan AL, Seeger K, Leonard AC, Erwin CR, Warner BW. Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis. J Pediatrics. 2007;150:358–63.
York DJ, Smazal AL, Robinson DT, De Plaen IG. Human Milk Growth Factors and Their Role in NEC Prevention: A Narrative Review. Nutrients. 2021;13:3751.
Article CAS PubMed PubMed Central Google Scholar
Hellström A, Ley D, Hansen-Pupp I, Hallberg B, Löfqvist C, van Marter L, et al. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016;105:576–86.
Article PubMed PubMed Central Google Scholar
Giapros VI, Schiza V, Challa AS, Pantou C, Theocharis PD, Andronikou SK. Serum insulin-like growth factor I (IGF-I), IGF-binding proteins-1 and -3, and postnatal growth of late preterm infants. Horm Metab Res. 2012;44:845–50.
Article CAS PubMed Google Scholar
Milsom SR, Blum WF, Gunn AJ. Temporal changes in insulin-like growth factors I and II and in insulin-like growth factor binding proteins 1, 2, and 3 in human milk. Horm Res. 2008;69:307–11.
Elmlinger MW, Hochhaus F, Loui A, Frommer KW, Obladen M, Ranke MB. Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants. Horm Res. 2007;68:124–31.
Baregamian N, Song J, Jeschke MG, Evers BM, Chung DH. IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis. J Surg Res. 2006;136:31–7.
Article CAS PubMed PubMed Central Google Scholar
Tian F, Liu GR, Li N, Yuan G. Insulin-like growth factor I reduces the occurrence of necrotizing enterocolitis by reducing inflammatory response and protecting intestinal mucosal barrier in neonatal rats model. Eur Rev Med Pharm Sci. 2017;21:4711–9.
Ozen S, Akisu M, Baka M, Yalaz M, Sozmen EY, Berdeli A, et al. Insulin-like growth factor attenuates apoptosis and mucosal damage in hypoxia/reoxygenation-induced intestinal injury. Biol Neonate 2005;87:91–6.
Article CAS PubMed Google Scholar
Ley D, Hallberg B, Hansen-Pupp I, Dani C, Ramenghi LA, Marlow N, et al. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial. J Pediatr. 2019;206:56–65.e8.
Article CAS PubMed Google Scholar
Loui A, Eilers E, Strauss E, Pohl-Schickinger A, Obladen M, Koehne P. Vascular Endothelial Growth Factor (VEGF) and soluble VEGF receptor 1 (sFlt-1) levels in early and mature human milk from mothers of preterm versus term infants. J Hum Lact. 2012;28:522–8.
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