Insights into AlphaFold’s breakthrough in neurodegenerative diseases

Weller J, Budson A (2018) Current understanding of Alzheimer’s disease diagnosis and treatment. F1000Research. https://doi.org/10.12688/f1000research.14506.1

Article  PubMed  PubMed Central  Google Scholar 

Silva MVF, Loures CD, Alves LCV et al (2019) Alzheimer’s disease: risk factors and potentially protective measures. J Biomed Sci 26(1):33. https://doi.org/10.1186/s12929-019-0524-y

Article  PubMed  PubMed Central  Google Scholar 

Bejanin A, Schonhaut DR, La Joie R et al (2017) Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease. Brain 140(12):3286–3300. https://doi.org/10.1093/brain/awx243

Article  PubMed  PubMed Central  Google Scholar 

Ling TS, Chandrasegaran S, Xuan LZ et al (2021) The potential benefits of nanotechnology in treating Alzheimer’s disease. Int, BioMed Res. https://doi.org/10.1155/2021/5550938

Book  Google Scholar 

Khan MQ, Mubeen H, Khan ZQ et al (2023) Computational insights into missense mutations in HTT gene causing Huntington’s disease and its interactome networks. Ir J Med Sci 192(3):1435–1445. https://doi.org/10.1007/s11845-022-03043-5

Article  CAS  PubMed  Google Scholar 

Giampietri L, Belli E, Beatino MF et al (2022) Fluid biomarkers in Alzheimer’s disease and other neurodegenerative disorders: toward integrative diagnostic frameworks and tailored treatments. Diagnostics 12(4):796. https://doi.org/10.3390/diagnostics12040796

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nalls MA, Blauwendraat C, Sargent L et al (2021) Evidence for GRN connecting multiple neurodegenerative diseases. Brain Commun. 3(2):fcab095. https://doi.org/10.1093/braincomms/fcab095

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strang KH, Golde TE, Giasson BI (2019) MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Lab Investig 99(7):912–928. https://doi.org/10.1038/s41374-019-0197-x

Article  PubMed  Google Scholar 

García-Morales V, González-Acedo A, Melguizo-Rodríguez L et al (2021) Current understanding of the physiopathology, diagnosis and therapeutic approach to Alzheimer’s disease. Biomedicines 9(12):1910. https://doi.org/10.3390/biomedicines9121910

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deetjen U, Meyer ET, Schroeder R (2015) Big data for advancing dementia research: an evaluation of data sharing practices in research on age-related neurodegenerative diseases. OECD Digital Economy Papers

Google Scholar 

Dashwood M, Churchhouse G, Young M, Kuruvilla T (2021) Artificial Intelligence as an aid to diagnosing dementia: an overview. Prog Neurol Psychiatry 25(3):42–47. https://doi.org/10.1002/pnp.721

Article  Google Scholar 

Patel UK, Anwar A, Saleem S et al (2021) Artificial Intelligence as an emerging technology in the current care of neurological disorders. J Neurol 268(5):1623–1642. https://doi.org/10.1007/s00415-019-09518-3

Article  PubMed  Google Scholar 

Subasi A, Kapadnis MN, Kosal Bulbul A (2022) Alzheimer’s disease detection using Artificial Intelligence. In: Pillai AS, Menon B (eds) Augmenting neurological disorder prediction and rehabilitation using Artificial Intelligence. Academic Press, pp 53–74. https://doi.org/10.1016/B978-0-323-90037-9.00011-4

Chapter  Google Scholar 

Choi ML, Gandhi S (2018) Crucial role of protein oligomerization in the pathogenesis of Alzheimer’s and Parkinson’s diseases. FEBS J 285(19):3631–3644. https://doi.org/10.1111/febs.14587

Article  CAS  PubMed  Google Scholar 

Navarro S, Ventura S (2022) Computational methods to predict protein aggregation. Curr Opin Struct Biol 73:102343. https://doi.org/10.1016/j.sbi.2022.102343

Article  CAS  PubMed  Google Scholar 

Lall D, Lorenzini I, Mota TA et al (2021) C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation. Neuron 109(14):2275-2291.e8. https://doi.org/10.1016/j.neuron.2021.05.020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Senior AW, Evans R, Jumper J et al (2020) Improved protein structure prediction using potentials from deep learning. Nature 577(7792):706–710. https://doi.org/10.1038/s41586-019-1923-7

Article  CAS  PubMed  Google Scholar 

Lamballais S, Muetzel RL, Ikram MA et al (2020) Genetic burden for late-life neurodegenerative disease and its association with early-life lipids, brain, behavior, and cognition. Front Psychiatry. https://doi.org/10.3389/fpsyt.2020.00033

Article  PubMed  PubMed Central  Google Scholar 

Lukiw WJ (2022) Recent advances in our molecular and mechanistic understanding of misfolded cellular proteins in Alzheimer’s disease (AD) and prion disease (PrD). Biomolecules 12(2):166. https://doi.org/10.3390/biom12020166

Article  CAS  PubMed  PubMed Central  Google Scholar 

Urayama A, Moreno-Gonzalez I, Morales-Scheihing D et al (2022) Preventive and therapeutic reduction of amyloid deposition and behavioral impairments in a model of Alzheimer’s disease by whole blood exchange. Mol Psychiatry 27(10):4285–4296. https://doi.org/10.1038/s41380-022-01679-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng C, Trojanowski JQ, Lee VMY (2020) Protein transmission in neurodegenerative disease. Nat Rev Neurol 16(4):199–212. https://doi.org/10.1038/s41582-020-0333-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alquezar C, Arya S, Kao AW (2021) Tau post-translational modifications: dynamic transformers of Tau function, degradation, and aggregation. Front Neurol. https://doi.org/10.3389/fneur.2020.595532

Article  PubMed  PubMed Central  Google Scholar 

Wells C, Brennan SE, Keon M et al (2019) Prionoid proteins in the pathogenesis of neurodegenerative diseases. Front Mol Neurosci 12:271

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan XW, Liu HJ, Hong YX et al (2022) lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer’s disease. J Neurogenet 36(1):11–20. https://doi.org/10.1080/01677063.2022.2028784

Article  CAS  PubMed  Google Scholar 

Ayodele T, Rogaeva E, Kurup JT et al (2021) Early-onset Alzheimer’s disease: what is missing in research? Curr Neurol Neurosci Rep 21(2):4. https://doi.org/10.1007/s11910-020-01090-y

Article  PubMed  PubMed Central  Google Scholar 

Liu H, Koros C, Strohäker T et al (2021) A novel SNCA A30G mutation causes familial Parkinsonʼs disease. Mov Disord 36(7):1624–1633. https://doi.org/10.1002/mds.28534

Article  CAS  PubMed  Google Scholar 

Sevenich M, Honold D, Willuweit A et al (2022) Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. Neurochem Int 161

Article  CAS  PubMed  Google Scholar 

Fanciulli A, Leys F, Lehner F et al (2022) A multiplex pedigree with pathologically confirmed multiple system atrophy and Parkinson’s disease with dementia. Brain Commun. 4(4):fcac175. https://doi.org/10.1093/braincomms/fcac175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herrmann F, Hessmann M, Schaertl S et al (2021) Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates. Sci Rep 11(1):17977. https://doi.org/10.1038/s41598-021-97334-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Podvin S, Rosenthal SB, Poon W et al (2022) Mutant huntingtin protein interaction map implicates dysregulation of multiple cellular pathways in neurodegeneration of Huntington’s disease. J Huntington’s Dis 11(3):243–267. https://doi.org/10.3233/JHD-220538

Article  CAS  Google Scholar 

Reilly M, Benilova I, Khalili-Shirazi A et al (2022) A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody. Sci Rep 12(1):9493. https://doi.org/10.1038/s41598-022-13455-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lakkaraju AKK, Sorce S, Senatore A et al (2022) Glial activation in prion diseases is selectively triggered by neuronal PrPSc. Brain Pathol 32(5):e13056. https://doi.org/10.1111/bpa.13056

Article  PubMed  PubMed Central  Google Scholar 

Otero A, Betancor M, Eraña H et al (2021) Prion-associated neurodegeneration causes both endoplasmic reticulum stress and proteasome impairment in a murine model of spontaneous disease. Int J Mol Sci 22(1):465. https://doi.org/10.3390/ijms22010465

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gribaudo S, Bousset L, Courte J et al (2023) Propagation of distinct α-synuclein strains within human reconstructed neuronal network and associated neuronal dysfunctions. In: Cieplak AS (ed) Protein aggregation: methods and protocols, methods in molecular biology. Springer, US New York, pp 357–378. https://doi.org/10.1007/978-1-0716-2597-2_24

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