Vinayak M, Nisha SS, Rachana S, Pallavi C. Solubility enhancement of labetalol hydrochloride by using liquisolid technique for management of hypertension. Int J Pharm Sci Res. 2022;13:5080–9. https://doi.org/10.13040/IJPSR.0975-8232.13(12).5080-89.

Article  Google Scholar 

The British pharmacopoeia commission secretariat of the medicines and healthcare products, regulatory agency, TSO, The stationary office, London. 2020.

The United States Pharmacopoeia, The National Formulary 25 Rockville, MD: US Pharmacopeial Convention, printed version 44, 2021.

Mikhail AK, Sergey MS, Nikita S, Ruslan P. Pavel NN (2023) Enantioseparation of β-blockers using silica-immobilised eremomycin derivatives as chiral stationary phases in HPLC. Symmetry. 2023;15:373. https://doi.org/10.3390/sym15020373.

Article  CAS  Google Scholar 

Kalkotwar RS, Laghave PK. RP-HPLC method development and validation for determination of labetalol in bulk and marketed formulation. Current Pharma Research. 2018;8:2447–57.

Article  CAS  Google Scholar 

Ashok CV, Sailaja BBV, Praveen KA. Stability indicating reverse-phase high-performance liquid chromatographic method for simultaneous estimation of labetalol and its degradation. Asian J Pharm Clin Res. 2016;9(Suppl. 2):242–9. https://doi.org/10.22159/ajpcr.2016.v9s2.13687.

Article  CAS  Google Scholar 

Khalid AMA, Nasr MEA, Ragab AMS, Ahmed EO, Sherif R. Computational investigation for practical HPLC determination of labetalol hydrochloride. Anal Chem Lett. 2016;6:697–705. https://doi.org/10.1080/22297928.2016.1249516.

Article  CAS  Google Scholar 

Bhalerao MR. HPTLC method development and validation for the estimation of labetalol hydrochloride in tablet dosage form. Pelagia Res Lib. 2014;5:59–63.

Google Scholar 

Hancu G, Papp LA, Szekely-Szentmiklosi B, Kelemen H. The use of antibiotics as chiral selectors in capillary electrophoresis: a review. Molecules. 2022;27:3601. https://doi.org/10.3390/molecules27113601.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pagidi R, Nimmakayala S, Devanna N, Srinivas M. Method development and validation of labetalol and nadolol in human plasma by LC-MS/MS. Sys Rev Pharm. 2021;12:528–34.

Google Scholar 

Pradeep SR, Punna RR, Laxman K, Rajeev SR. Development and validation of a bio-analytical method for simultaneous quantification of nebivolol and labetalol in aqueous humor and plasma using LC-MS/MS and its application to ocular pharmacokinetic studies. J Chrom B. 2020;1136:121908. https://doi.org/10.1016/j.jchromb.2019.121908.

Article  CAS  Google Scholar 

Mazaraki K, Kabir A, Furton KG, Fytianos K, Samanidou VF, Zacharis CK. Fast fabric phase sorptive extraction of selected β-blockers from human serum and urine followed by UHPLC-ESI-MS/MS analysis. J Pharm Biomed Anal. 2021;199:114053. https://doi.org/10.1016/j.jpba.2021.114053.

Article  CAS  PubMed  Google Scholar 

Hassan A, Gul S, Mahmood T, Khan FU, Hasan S, Qadeer Q. A comparative study of labetalol via electrochemical and computational methods. Iran J Chem Chem Eng. 2022;41:1694–704.

CAS  Google Scholar 

Mahmoud AO, Sayed MD, Mohamed AAL, Mohamed AEHamd. Derivatization of labetalol hydrochloride for its spectrofluorimetric and spectrophotometric determination in human plasma: Application to stability study. Spectrochim Acta Part A Molecular Biomol Spect. 2018;190:457–63.

Article  Google Scholar 

Sayed MD, Mahmoud AO, Mohamed AKAL, Ahmed IH. Development and validation of a new spectrofluorimetric method for the determination of some beta-blockers through fluorescence quenching of eosin Y. Application to content uniformity test. Open Chem. 2016;14:258–66. https://doi.org/10.1515/chem-2016-0024.

Article  CAS  Google Scholar 

Mariani AC, Jany HFDJ, Eder TGC. Investigation of the thermal behavior of labetalol. Thermochim Acta. 2018;668:33–9. https://doi.org/10.1016/j.tca.2018.08.002.

Article  CAS  Google Scholar 

Sachin SK, Saurabh AD, Shankar MD, Vikas DK. Development and validation of Q-absorbance ratio spectrophotometric method simultaneous estimation of simvastatin and labetalol HCl in combined dosage form. Pharm Res. 2021;4:57–61.

Google Scholar 

Maissa YS, Nagiba YH, Yasmin MF, Samah AESM, Enas SA. Electrochemical quantitative assessment of labetalol hydrochloride in pure form and combined pharmaceutical formulations. Acta Chim Slov. 2020;67:396–402. https://doi.org/10.17344/acsi.2019.5140.

Article  CAS  Google Scholar 

Akshada DS, Shankar MD, Suchita RA, Salim GP. Estimation of labetalol hydrochloride in bulk and formulation by uv-spectrophotometric area under curve. J Drug Delivery Ther. 2019;9(2019):168–70. https://doi.org/10.22270/jddt.v9i3.2633.

Article  CAS  Google Scholar 

Abdalla AE, Abir AA, Shazalia MAA, Hassan YAE. 1,2-naphthoquinone-4-sulphonic acid sodium salt (NQS) as an analytical reagent for the determination of pharmaceutical amine by spectrophotometry. App Spectros Rev. 2012;47:219–32. https://doi.org/10.1080/05704928.2011.639107.

Article  CAS  Google Scholar 

Naik BE, Rao CN, Ramanaiah S, Venkateswarlu P. Spectrophotometric determination of labetalol in pure and dosage forms. Indian J Adv Chem Sci. 2018;6:41–4.

CAS  Google Scholar 

Khalid AMA, Nasr MEA, Sherif R. Two wavelengths dependant stability-indicating spectrophotometric methods for determination of labetalol hydrochloride in the presence of its oxidative degradation product: a comparative study. Anal Chem Lett. 2015;5:351–63. https://doi.org/10.1080/22297928.2015.1135077.

Article  CAS  Google Scholar 

Manasa O, Ravindra RK, Venkatesh P, Hepcykala RD, Sirisha G, Sahithireddy P. Development of new and rapid method for uv spectrophotometric determination of labetalol in marketed formulations. Der Pharma Chem. 2014;6:299–302.

Google Scholar 

Mohamed HM, Lamie NT. Analytical eco-scale for assessing the greenness of a developed RP-HPLC method used for simultaneous analysis of combined antihypertensive medications. J AOAC Int. 2016;99:1260–5. https://doi.org/10.5740/jaoacint.16-0124.

Article  CAS  PubMed  Google Scholar 

International conference on harmonisation, council for harmonization of technical requirements for pharmaceutical for human use. Validation of analytical procedures Q2(R2). 2022. EMA/CHMP/ICH/82072/2006.

Haque SM, Abuzar K, Nafisur R, Syed NHA. Response surface methodology combined Box-Behnken design optimized green kinetic spectrophotometric and HPLC methods to quantify angiotensin receptor blocker valsartan in pharmaceutical formulations. Spectrochim Acta Part A Molecular Biomol Spect. 2023;298:122805. https://doi.org/10.1016/j.saa.2023.122805.

Article  CAS  Google Scholar 

Haque SM, Umar Y, Al-Batty S, Sarief A, Abu-Judeh A, Al-Awwad H, Rahman H. Charge transfer based green spectrophotometric method to determine remogliflozin etabonate applying response surface methodology supported with computational studies in pharmaceutical formulations. Sustainable Chem Pharm. 2023;35:101193. https://doi.org/10.1016/j.scp.2023.101193.

Article  CAS  Google Scholar 

Azmi SNH, Hoqani UA, Mamari JOSA, Mamari BMSA, Jassasi BSARA, Rubaiai ASSA, Rahman N, Nasir M, Haque SM, Khan SA, Ahmed QU, Zakaria ZA. Box-Behnken design-based development of uv-reversed phase high-performance liquid chromatographic method for determination of ascorbic acid in tablet formulations. Separations. 2023;9:361. https://doi.org/10.3390/separations9110361.

Article  CAS  Google Scholar 

SK Manirul Haque. Application of combined Box-Behnken design with response surface methodology and desirability function in optimizing pectin extraction from fruit peels. J Sci Food Agri. 2024;104:149–73. https://doi.org/10.1002/jsfa.12925.

Article  CAS  Google Scholar 

Al-Batty S, Haque SM, Rahman N, Azmi SNH. Optimized Box-Behnken design combined response surface methodology to determine calcium and iron contents using visible, atomic emission and atomic absorption spectrophotometry in vegetables and wastewater samples. J AOAC Int. 2023;106:99–111. https://doi.org/10.1093/jaoacint/qsac106.

Article  Google Scholar 

Haque SM. Validated Kinetic Spectrophotometric methods to optimize robustness study with youden factorial combinations to determine repaglinide using response surface methodology via Box-Behnken design. Arab J Sci Eng. 2023;48:129–44. https://doi.org/10.1007/s13369-022-06782-w.

Article  CAS  Google Scholar 

Haque SM. Optimized Box-Behnken experimental design-based response surface methodology and Youden’s robustness test to develop and validate methods to determine nateglinide using kinetic spectrophotometry. Spectrochim Acta A Mol Biomol Spectrosc. 2022;268:120712. https://doi.org/10.1016/j.saa.2021.120712.

Article  CAS  PubMed  Google Scholar 

Haque SM. Box-Behnken experimental design for optimizing the HPLC method to determine hydrochlorothiazide in pharmaceutical formulations and biological fluid. J Mol Liq. 2022;352:118708. https://doi.org/10.1016/j.molliq.2022.118708.

Article  CAS  Google Scholar 

Hsu YT, Su CS. Application of Box-Behnken design to investigate the effect of process parameters on the microparticle production of ethenzamide through the rapid expansion of the supercritical solutions process. Pharmaceutics. 2020;12:42. https://doi.org/10.3390/pharmaceutics12010042.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vlada BV, Ana VV, Jelena MA, Olivera SS. Modeling of biodiesel production: performance comparison of Box-Behnken, face central composite and full factorial design. Chin J Chem Eng. 2019;27:1690–8. https://doi.org/10.1016/j.cjche.2018.08.002.

Article  CAS  Google Scholar 

Judeh AA, Sarief A, Umar Y, Ashwaq O, Haque SM. Development, computational studies and validation of spectrophotometric method of metformin hydrochloride in pharmaceutical formulations. J Chil Chem Soc. 2020;65:4895–9. https://jcchems.com/index.php/JCCHEMS/article/view/1518.

Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, Scalmani G, Barone V, Mennucci B, Petersson GA, Nakatsuji H, Caricato M, Li X, Hratchian HP, Izmaylov AF, Bloino J, Zheng G, Sonnenberg JL, Hada M, Ehara M, Toyota K, Fukuda R, Hasegawa J, Ishida M, Nakajima T, Honda Y, Kitao O, Nakai H, Vreven T, Montgomery JA, Peralta JE, Ogliaro F, Bearpark M, Heyd JJ, Brothers E, Kudin KN, Staroverov VN, Kobayashi R, Normand J, Raghavachari K, Rendell A, Burant JC, Iyengar SS, Tomasi J, Cossi M, Rega N, Millam JM, Klene M, Knox JE, Cross JB, Bakken V, Adamo C, Jaramillo J, Gomperts R, Stratmann RE, Yazyev O, Austin AJ, Cammi R, Pomelli C, Ochterski JW, Martin RL, Morokuma K, Zakrzewski VG, Voth GA, Salvador P, Dannenberg JJ, Dapprich S, Daniels AD, Farkas O, Foresman JB, Ortiz JV, Cioslowski J, Fox DJ. Gaussian 09, Revision 02. Gaussian Inc, Wallingford CT. 2009. https://Gaussian.com//g09citation/.

Umar Y, Morsy MA. Ab initio and DFT studies of the molecular structures and vibrational spectra of succinonitrile. Spectrochim. Acta Part A: Mol Biomol Spectrosc. 2007;66:1133–40. https://doi.org/10.1016/j.saa.2006.05.026.

Article  CAS  Google Scholar 

Yeoh PH, Lim KZ, Tan EL, Rhyman L, Umar Y, Abdallah HH, Ramasami P. Internal rotation of 2-, 3- and 4- pyridine carboxaldehydes and their chalcogen analogues (S and Se) in the gas and solution phases: a theoretical investigation. J Solution Chem. 2016;45:1195–212. https://doi.org/10.1007/s10953-016-0499-1.

Article  CAS  Google Scholar 

Umar Y, Tijani J, Abdalla S. Conformational stabilities, rotational barriers, and vibrational spectra of 2-pyrrolecarboxaldehyde and 3-pyrrolecarboxaldehyde calculated using density functional theory. J Struct Chem. 2019;60:186–97. https://doi.org/10.1134/S0022476619020033.

Article  CAS  Google Scholar 

Al-Hazmi GH, Hassanien AM, Atta AA, Refat MS, Saad HA, Shakya S, Adam AMA. Supramolecular charge-transfer complex generated by the interaction between tin(II) 2,3-naphtalocyanine as a donor with DDQ as an acceptor: spectroscopic studies in solution state and theoretical calculations. J Mol Liq. 2022;362:119757. https://doi.org/10.1016/j.molliq.2022.119757.

Article  CAS