United Nations Department of Economic and Social Affairs Population Division. World Population Ageing 2015. 2015; Available from: http://www.un.org/en.
Anderson S, Halter JB, Hazzard WR, Himmelfarb J, Horne FM, Kaysen GA, et al. Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am Soc Nephrol. 2009;20:1199–209.
Article CAS PubMed Google Scholar
Liu P, Quinn RR, Lam NN, Elliott MJ, Xu Y, James MT, et al. 5-accounting for age in the definition of chronic kidney disease. JAMA Intern Med. 2021;181:1359–66.
Article PubMed PubMed Central Google Scholar
Cortes-Canteli M, Iadecola C. Alzheimer’s disease and vascular aging: Jacc focus seminar. J Am Coll Cardiol. 2020;75:942–51.
Article CAS PubMed PubMed Central Google Scholar
Minutolo R, Borrelli S, De Nicola L. Ckd in the elderly: Kidney senescence or blood pressure-related nephropathy? Am J Kidney Dis. 2015;66:184–6.
Hommos MS, Glassock RJ, Rule AD. Structural and functional changes in human kidneys with healthy aging. J Am Soc Nephrol. 2017;28:2838–44.
Article PubMed PubMed Central Google Scholar
O’Sullivan ED, Hughes J, Ferenbach DA. Renal aging: Causes and consequences. J Am Soc Nephrol. 2017;28:407–20.
Hernandez-Segura A, Nehme J, Demaria M. Hallmarks of cellular senescence. Trends Cell Biol. 2018;28:436–53.
Article CAS PubMed Google Scholar
Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM. Cellular senescence in renal ageing and disease. Nat Rev Nephrol. 2017;13:77–89.
Article CAS PubMed Google Scholar
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, et al. Naturally occurring p16(ink4a)-positive cells shorten healthy lifespan. Nature. 2016;530:184–9.
Article CAS PubMed PubMed Central Google Scholar
Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, et al. Senescent cells: An emerging target for diseases of ageing. Nat Rev Drug Discov. 2017;16:718–35.
Article CAS PubMed PubMed Central Google Scholar
Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol. 1956;11:298–300.
Article CAS PubMed Google Scholar
Kruk PA, Rampino NJ, Bohr VA. DNA damage and repair in telomeres: Relation to aging. Proc Natl Acad Sci USA. 1995;92:258–62.
Article CAS PubMed PubMed Central Google Scholar
Petrova NV, Velichko AK, Razin SV, Kantidze OL. Small molecule compounds that induce cellular senescence. Aging Cell. 2016;15:999–1017.
Article CAS PubMed PubMed Central Google Scholar
Schmitt R, Melk A. Molecular mechanisms of renal aging. Kidney Int. 2017;92:569–79.
Article CAS PubMed Google Scholar
Gallage S, Gil J. Mitochondrial dysfunction meets senescence. Trends Biochem Sci. 2016;41:207–9.
Article CAS PubMed Google Scholar
Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochondrial dysfunction in cell senescence and aging. J Clin Invest. 2022;132:e158447.
Article CAS PubMed PubMed Central Google Scholar
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429:417–23.
Article CAS PubMed Google Scholar
Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005;309:481–4.
Article CAS PubMed Google Scholar
Sun N, Youle RJ, Finkel T. The mitochondrial basis of aging. Mol Cell. 2016;61:654–66.
Article CAS PubMed PubMed Central Google Scholar
Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab. 2016;23:303–14.
Article CAS PubMed Google Scholar
Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA. Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nat Rev Endocrinol. 2022;18:243–58.
Article PubMed PubMed Central Google Scholar
Miao J, Liu J, Niu J, Zhang Y, Shen W, Luo C, et al. Wnt/β-catenin/ras signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell. 2019;18:e13004.
Article PubMed PubMed Central Google Scholar
Martin N, Bernard D. Calcium signaling and cellular senescence. Cell Calcium. 2018;70:16–23.
Article CAS PubMed Google Scholar
Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K, et al. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature. 2010;465:368–72.
Article CAS PubMed PubMed Central Google Scholar
Manda KR, Tripathi P, Hsi AC, Ning J, Ruzinova MB, Liapis H, et al. Nfatc1 promotes prostate tumorigenesis and overcomes pten loss-induced senescence. Oncogene. 2016;35:3282–92.
Article CAS PubMed Google Scholar
Madreiter-Sokolowski CT, Waldeck-Weiermair M, Bourguignon MP, Villeneuve N, Gottschalk B, Klec C, et al. Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging. Redox Biol. 2019;20:458–66.
Article CAS PubMed Google Scholar
Madreiter-Sokolowski CT, Thomas C, Ristow M. Interrelation between ros and Ca2+ in aging and age-related diseases. Redox Biol. 2020;36:101678.
Article CAS PubMed PubMed Central Google Scholar
Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calve B, Augert A, et al. Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nat Commun. 2014;5:3792.
Article CAS PubMed Google Scholar
Görlach A, Bertram K, Hudecova S, Krizanova O. Calcium and ros: A mutual interplay. Redox Biol. 2015;6:260–71.
Article PubMed PubMed Central Google Scholar
Denton RM. Regulation of mitochondrial dehydrogenases by calcium ions. Biochim Biophys Acta. 2009;1787:1309–16.
Article CAS PubMed Google Scholar
Huang G, Docampo R. The mitochondrial calcium uniporter interacts with subunit c of the atp synthase of trypanosomes and humans. mBio. 2020;11:e00268–20.
Article CAS PubMed PubMed Central Google Scholar
Hubbard MJ, McHugh NJ. Mitochondrial atp synthase f1-beta-subunit is a calcium-binding protein. FEBS Lett. 1996;391:323–9.
Article CAS PubMed Google Scholar
Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS. Calcium, atp, and ros: A mitochondrial love-hate triangle. Am J Physiol Cell Physiol. 2004;287:C817–33.
Article CAS PubMed Google Scholar
De Marchi E, Bonora M, Giorgi C, Pinton P. The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux. Cell Calcium. 2014;56:1–13.
Article PubMed PubMed Central Google Scholar
Yu EPK, Reinhold J, Yu H, Starks L, Uryga AK, Foote K, et al. Mitochondrial respiration is reduced in atherosclerosis, promoting necrotic core formation and reducing relative fibrous cap thickness. Arterioscler Thromb Vasc Biol. 2017;37:2322–32.
Article CAS PubMed PubMed Central Google Scholar
Garbincius JF, Elrod JW. Mitochondrial calcium exchange in physiology and disease. Physiol Rev. 2022;102:893–992.
Article CAS PubMed Google Scholar
Rizzuto R, De Stefani D, Raffaello A, Mammucari C. Mitochondria as sen
留言 (0)