Elborn, S. Cystic fibrosis. Lancet 388, 2519–2531 (2016).
Article CAS PubMed Google Scholar
Kalivianakis, M. et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. Am. J. Clin. Nutr. 69, 127–134 (1999).
Article CAS PubMed Google Scholar
Yen, E. H., Quinton, H. & Borowitz, D. Better nutritional status in early childhood is associated with improved clinical outcomes and survival in patients with cystic fibrosis. J. Pediatr. 162, 530–535 (2013).
Borowitz, D. et al. Gastrointestinal outcomes and confounders in cystic fibrosis. J. Pediatr. Gastroenterol. Nutr. 41, 273–285 (2005).
Bass, R., Brownell, J. N. & Stallings, V. A. The impact of highly effective CFTR modulators on growth and nutrition status. Nutrients 13, 2907 (2021).
Article CAS PubMed PubMed Central Google Scholar
Humbert, L. et al. Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients. J. Lipid Res. 59, 2202–2213 (2018).
Article CAS PubMed PubMed Central Google Scholar
Gelfond, D., Ma, C., Semler, J. & Borowitz, D. Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule. Dig. Dis. Sci. 58, 2275–2281 (2013).
Article CAS PubMed Google Scholar
Hunter, J. E. Studies on effects of dietary fatty acids as related to their position on triglycerides. Lipids 36, 655–668 (2001).
Article CAS PubMed Google Scholar
Carey, M. C. Digestion and absorption of fat. Sem. Gastrointest. Dis. 3, 189–208 (1992).
Caley, L. R. et al. Cystic fibrosis-related gut dysbiosis: a systematic review. Dig. Dis. Sci. 68, 1–18 (2023).
Coffey, M. J. et al. Gut microbiota in children with cystic fibrosis: a taxonomic and functional dysbiosis. Sci. Rep. 9, 1–14 (2019).
Marsh, R. G. et al. Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis. J. Cyst. Fibros. 21, 506–513 (2022).
Article CAS PubMed Google Scholar
Calvo-Lerma, J. et al. Association between faecal pH and fat absorption in children with cystic fibrosis on a controlled diet and enzyme supplements dose. Pediatr. Res. 89, 205–210 (2021).
Article CAS PubMed Google Scholar
Roca, M. et al. Fecal calprotectin in healthy children aged 4–16 years. Sci. Rep. 10, 20565 (2020).
Article CAS PubMed PubMed Central Google Scholar
Lluesa, J. H. et al. Lipidic profiles of patients starting peritoneal dialysis suggest an increased cardiovascular risk beyond classical dyslipidemia biomarkers. Sci. Rep. 12, 16394 (2022).
Article CAS PubMed PubMed Central Google Scholar
Chen, S., Zhou, Y., Chen, Y. & Gu, J. Fastp: an Ultra-fast All-In-One FASTQ Preprocessor. Bioinformatics 34, i884–i890 (2018).
Article PubMed PubMed Central Google Scholar
Magoč, T. & Salzberg, S. L. FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics 27, 2957–2963 (2011).
Article PubMed PubMed Central Google Scholar
Callahan, B. J. et al. DADA2: high-resolution sample inference from Illumina amplicon data. Nat. Methods 13, 581–583 (2016).
Article CAS PubMed PubMed Central Google Scholar
Team, R. D. C. A language and environment for statistical computing. http://www.R-project.org. (2009)
McMurdie, P. J. & Holmes, S. phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PloS one 8, e61217 (2013).
Article CAS PubMed PubMed Central Google Scholar
. Microbiome R package. URL: http://microbiome.github.io
Gaujoux, R. & Seoighe, C. A flexible R package for nonnegative matrix factorization. BMC Bioinforma. 11, 1–9 (2010).
Bürkner, P. C. Bayesian item response modeling in R with brms and Stan. arXiv 2020. arXiv preprint arXiv:1905.09501.
Bürkner, P. C. & Charpentier, E. Monotonic effects: A principled approach for including ordinal predictors in regression models. PsyArXiv Preprints. 1-20 (2018).
Wickham, H., Chang, W. & Wickham, M. H. Package ‘ggplot2’. Create elegant data visualisations using the grammar of graphics. Version 2, 1–189 (2016).
Calvo-Lerma, J. et al. Clinical evaluation of an evidence-based method based on food characteristics to adjust pancreatic enzyme supplements dose in cystic fibrosis. J. Cyst. Fibros. 20, e33–e39 (2021).
Article CAS PubMed Google Scholar
Tso, P., Kendrick, H., Balint, J. A. & Simmonds, W. J. Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat. Gastroenterology 80, 60–65 (1981).
Article CAS PubMed Google Scholar
Calvo-Lerma, J., Fornés-Ferrer, V., Heredia, A. & Andrés, A. In vitro digestion models to assess lipolysis: the impact of the simulated conditions of gastric and intestinal pH, bile salts and digestive fluids. Food Res. Int. 125, 108511 (2019).
Article CAS PubMed Google Scholar
Oliphant, K. & Allen-Vercoe, E. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome 7, 1–15 (2019).
Ocvirk, S. & O’Keefe, S. J. Dietary fat, bile acid metabolism and colorectal cancer. Semin. Cancer Biol. 73, 347–355 (2021).
Article CAS PubMed Google Scholar
Haasbroek, K., Takabe, W., Yagi, M. & Yonei, Y. High-fat Diet Induced Dysbiosis & Amelioration by Astaxanthin. Med. Sci. 48, 58–66 (2019).
De Weirdt, T. et al. Human faecal microbiota display variable patterns of glycerol metabolism. FEMS Microbiol. Ecol. 74, 601–611 (2010).
Antosca, K. M. et al. Altered stool microbiota of infants with cystic fibrosis shows a reduction in genera associated with immune programming from birth. J. Bacteriol. 201, e00274–19 (2019).
Article CAS PubMed PubMed Central Google Scholar
Cândido, F. G. et al. Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity. Int. J. Food Sci. Nutr. 69, 125–143 (2018).
Gardiner, B. J. et al. Clinical and microbiological characteristics of Eggerthella lenta bacteremia. J. Clin. Microbiol. 53, 626–635 (2015).
Article CAS PubMed PubMed Central Google Scholar
King, P. Haemophilus influenzae and the lung (Haemophilus and the lung). Clin. Transl. Med. 1, 1–9 (2012).
Price, C. E. & O’Toole, G. A. The gut-lung axis in cystic fibrosis. J. Bacteriol. 203, e00311–e00321 (2021).
Article CAS PubMed PubMed Central Google Scholar
Tod, J. & Fine, D. Fecal elastase: a useful test for pancreatic insufficiency? Dig. Dis. Sci. 55, 2709–2711 (2010).
Calvo‐Lerma, J., Fornés‐Ferrer, V., Heredia, A. & Andrés, A. In vitro digestion of lipids in real foods: influence of lipid organization within the food matrix and interactions with nonlipid components. J. Food Sci. 83, 2629–2637 (2018).
Article PubMed PubMed Central Google Scholar
Kim, M. S., Hwang, S. S., Park, E. J. & Bae, J. W. Strict vegetarian diet improves the risk factors associated with metabolic diseases by modulating gut microbiota and reducing intestinal inflammation. Environ. Microbiol. Rep. 5, 765–775 (2013).
Article CAS PubMed Google Scholar
Dehghan, P., Gargari, B. P. & Jafar-Abadi, M. A. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition 30, 418–423 (2014).
Article CAS PubMed Google Scholar
Ng, S. M. & Moore, H. S. Drug therapies for reducing gastric acidity in people with cystic fibrosis. Cochrane Database Syst. Rev. 4, CD003424 (2021).
van Dorst, J. M., Tam, R. Y. & Ooi, C. Y. What Do We Know about the Microbiome in Cystic Fibrosis? Is There a Role for Probiotics and Prebiotics? Nutrients 14, 480 (2022).
Article PubMed PubMed Central Google Scholar
Lamichhane, S. et al. Linking gut microbiome and lipid metabolism: moving beyond associations. Metabolites 11, 55 (2021).
留言 (0)