Faecal lipid profile as a new marker of fat maldigestion, malabsorption and microbiota

Elborn, S. Cystic fibrosis. Lancet 388, 2519–2531 (2016).

Article  CAS  PubMed  Google Scholar 

Kalivianakis, M. et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. Am. J. Clin. Nutr. 69, 127–134 (1999).

Article  CAS  PubMed  Google Scholar 

Yen, E. H., Quinton, H. & Borowitz, D. Better nutritional status in early childhood is associated with improved clinical outcomes and survival in patients with cystic fibrosis. J. Pediatr. 162, 530–535 (2013).

Article  PubMed  Google Scholar 

Borowitz, D. et al. Gastrointestinal outcomes and confounders in cystic fibrosis. J. Pediatr. Gastroenterol. Nutr. 41, 273–285 (2005).

Article  PubMed  Google Scholar 

Bass, R., Brownell, J. N. & Stallings, V. A. The impact of highly effective CFTR modulators on growth and nutrition status. Nutrients 13, 2907 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Humbert, L. et al. Postprandial bile acid levels in intestine and plasma reveal altered biliary circulation in chronic pancreatitis patients. J. Lipid Res. 59, 2202–2213 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gelfond, D., Ma, C., Semler, J. & Borowitz, D. Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule. Dig. Dis. Sci. 58, 2275–2281 (2013).

Article  CAS  PubMed  Google Scholar 

Hunter, J. E. Studies on effects of dietary fatty acids as related to their position on triglycerides. Lipids 36, 655–668 (2001).

Article  CAS  PubMed  Google Scholar 

Carey, M. C. Digestion and absorption of fat. Sem. Gastrointest. Dis. 3, 189–208 (1992).

Google Scholar 

Caley, L. R. et al. Cystic fibrosis-related gut dysbiosis: a systematic review. Dig. Dis. Sci. 68, 1–18 (2023).

Coffey, M. J. et al. Gut microbiota in children with cystic fibrosis: a taxonomic and functional dysbiosis. Sci. Rep. 9, 1–14 (2019).

Article  Google Scholar 

Marsh, R. G. et al. Intestinal function and transit associate with gut microbiota dysbiosis in cystic fibrosis. J. Cyst. Fibros. 21, 506–513 (2022).

Article  CAS  PubMed  Google Scholar 

Calvo-Lerma, J. et al. Association between faecal pH and fat absorption in children with cystic fibrosis on a controlled diet and enzyme supplements dose. Pediatr. Res. 89, 205–210 (2021).

Article  CAS  PubMed  Google Scholar 

Roca, M. et al. Fecal calprotectin in healthy children aged 4–16 years. Sci. Rep. 10, 20565 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lluesa, J. H. et al. Lipidic profiles of patients starting peritoneal dialysis suggest an increased cardiovascular risk beyond classical dyslipidemia biomarkers. Sci. Rep. 12, 16394 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, S., Zhou, Y., Chen, Y. & Gu, J. Fastp: an Ultra-fast All-In-One FASTQ Preprocessor. Bioinformatics 34, i884–i890 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Magoč, T. & Salzberg, S. L. FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics 27, 2957–2963 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Callahan, B. J. et al. DADA2: high-resolution sample inference from Illumina amplicon data. Nat. Methods 13, 581–583 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Team, R. D. C. A language and environment for statistical computing. http://www.R-project.org. (2009)

McMurdie, P. J. & Holmes, S. phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data. PloS one 8, e61217 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

. Microbiome R package. URL: http://microbiome.github.io

Gaujoux, R. & Seoighe, C. A flexible R package for nonnegative matrix factorization. BMC Bioinforma. 11, 1–9 (2010).

Article  Google Scholar 

Bürkner, P. C. Bayesian item response modeling in R with brms and Stan. arXiv 2020. arXiv preprint arXiv:1905.09501.

Bürkner, P. C. & Charpentier, E. Monotonic effects: A principled approach for including ordinal predictors in regression models. PsyArXiv Preprints. 1-20 (2018).

Wickham, H., Chang, W. & Wickham, M. H. Package ‘ggplot2’. Create elegant data visualisations using the grammar of graphics. Version 2, 1–189 (2016).

Google Scholar 

Calvo-Lerma, J. et al. Clinical evaluation of an evidence-based method based on food characteristics to adjust pancreatic enzyme supplements dose in cystic fibrosis. J. Cyst. Fibros. 20, e33–e39 (2021).

Article  CAS  PubMed  Google Scholar 

Tso, P., Kendrick, H., Balint, J. A. & Simmonds, W. J. Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat. Gastroenterology 80, 60–65 (1981).

Article  CAS  PubMed  Google Scholar 

Calvo-Lerma, J., Fornés-Ferrer, V., Heredia, A. & Andrés, A. In vitro digestion models to assess lipolysis: the impact of the simulated conditions of gastric and intestinal pH, bile salts and digestive fluids. Food Res. Int. 125, 108511 (2019).

Article  CAS  PubMed  Google Scholar 

Oliphant, K. & Allen-Vercoe, E. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome 7, 1–15 (2019).

Article  Google Scholar 

Ocvirk, S. & O’Keefe, S. J. Dietary fat, bile acid metabolism and colorectal cancer. Semin. Cancer Biol. 73, 347–355 (2021).

Article  CAS  PubMed  Google Scholar 

Haasbroek, K., Takabe, W., Yagi, M. & Yonei, Y. High-fat Diet Induced Dysbiosis & Amelioration by Astaxanthin. Med. Sci. 48, 58–66 (2019).

Google Scholar 

De Weirdt, T. et al. Human faecal microbiota display variable patterns of glycerol metabolism. FEMS Microbiol. Ecol. 74, 601–611 (2010).

Article  PubMed  Google Scholar 

Antosca, K. M. et al. Altered stool microbiota of infants with cystic fibrosis shows a reduction in genera associated with immune programming from birth. J. Bacteriol. 201, e00274–19 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cândido, F. G. et al. Impact of dietary fat on gut microbiota and low-grade systemic inflammation: mechanisms and clinical implications on obesity. Int. J. Food Sci. Nutr. 69, 125–143 (2018).

Article  PubMed  Google Scholar 

Gardiner, B. J. et al. Clinical and microbiological characteristics of Eggerthella lenta bacteremia. J. Clin. Microbiol. 53, 626–635 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

King, P. Haemophilus influenzae and the lung (Haemophilus and the lung). Clin. Transl. Med. 1, 1–9 (2012).

Article  Google Scholar 

Price, C. E. & O’Toole, G. A. The gut-lung axis in cystic fibrosis. J. Bacteriol. 203, e00311–e00321 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tod, J. & Fine, D. Fecal elastase: a useful test for pancreatic insufficiency? Dig. Dis. Sci. 55, 2709–2711 (2010).

Article  PubMed  Google Scholar 

Calvo‐Lerma, J., Fornés‐Ferrer, V., Heredia, A. & Andrés, A. In vitro digestion of lipids in real foods: influence of lipid organization within the food matrix and interactions with nonlipid components. J. Food Sci. 83, 2629–2637 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Kim, M. S., Hwang, S. S., Park, E. J. & Bae, J. W. Strict vegetarian diet improves the risk factors associated with metabolic diseases by modulating gut microbiota and reducing intestinal inflammation. Environ. Microbiol. Rep. 5, 765–775 (2013).

Article  CAS  PubMed  Google Scholar 

Dehghan, P., Gargari, B. P. & Jafar-Abadi, M. A. Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition 30, 418–423 (2014).

Article  CAS  PubMed  Google Scholar 

Ng, S. M. & Moore, H. S. Drug therapies for reducing gastric acidity in people with cystic fibrosis. Cochrane Database Syst. Rev. 4, CD003424 (2021).

PubMed  Google Scholar 

van Dorst, J. M., Tam, R. Y. & Ooi, C. Y. What Do We Know about the Microbiome in Cystic Fibrosis? Is There a Role for Probiotics and Prebiotics? Nutrients 14, 480 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Lamichhane, S. et al. Linking gut microbiome and lipid metabolism: moving beyond associations. Metabolites 11, 55 (2021).

Article  CAS 

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