Allogeneic haematopoietic stem cell transplantation might overcome the poor prognosis of adolescents and adult patients with T-lineage acute lymphoblastic leukaemia and CDKN2 deletion

Van Vlierberghe P, Ambesi-Impiombato A, De Keersmaecker K, Hadler M, Paietta E, Tallman MS, et al. Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia. Blood. 2013;122:74–82. https://doi.org/10.1182/blood-2013-03-491092.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jabbour E, Pui CH, Kantarjian H. Progress and innovations in the management of adult acute lymphoblastic leukemia. JAMA Oncol. 2018;4:1413–20. https://doi.org/10.1001/jamaoncol.2018.1915.

Article  PubMed  Google Scholar 

La Starza R, Pierini V, Pierini T, Nofrini V, Matteucci C, Arniani S, et al. Design of a comprehensive fluorescence in situ hybridization assay for genetic classification of T-cell acute lymphoblastic leukemia. J Mol Diagn. 2020;22:629–39. https://doi.org/10.1016/j.jmoldx.2020.02.004.

Article  CAS  PubMed  Google Scholar 

Iacobucci I, Ferrari A, Lonetti A, Papayannidis C, Paoloni F, Trino S, et al. CDKN2A/B alterations impair prognosis in adult BCR-ABL1-positive acute lymphoblastic leukemia patients. Clin Cancer Res. 2011;17:7413–23. https://doi.org/10.1158/1078-0432.Ccr-11-1227.

Article  CAS  PubMed  Google Scholar 

Moorman AV, Schwab C, Ensor HM, Russell LJ, Morrison H, Jones L, et al. IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia. J Clin Oncol. 2012;30:3100–8. https://doi.org/10.1200/jco.2011.40.3907.

Article  PubMed  Google Scholar 

Ribera J, Morgades M, Zamora L, Montesinos P, Gómez-Seguí I, Pratcorona M, et al. Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocols. Cancer. 2015;121:3809–17. https://doi.org/10.1002/cncr.29579.

Article  CAS  PubMed  Google Scholar 

Patel S, Mason CC, Glenn MJ, Paxton CN, South ST, Cessna MH, et al. Genomic analysis of adult B-ALL identifies potential markers of shorter survival. Leuk Res. 2017;56:44–51. https://doi.org/10.1016/j.leukres.2017.01.034.

Article  CAS  PubMed  Google Scholar 

Marks DI, Paietta EM, Moorman AV, Richards SM, Buck G, DeWald G, et al. T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993). Blood. 2009;114:5136–45. https://doi.org/10.1182/blood-2009-08-231217.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grossmann V, Haferlach C, Weissmann S, Roller A, Schindela S, Poetzinger F, et al. The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Genes Chromosomes Cancer. 2013;52:410–22. https://doi.org/10.1002/gcc.22039.

Article  CAS  PubMed  Google Scholar 

Dirse V, Bertasiute A, Gineikiene E, Zvirblis T, Dambrauskiene R, Gerbutavicius R, et al. A population-based single nucleotide polymorphism array analysis of genomic aberrations in younger adult acute lymphoblastic leukemia patients. Genes Chromosomes Cancer. 2015;54:326–33. https://doi.org/10.1002/gcc.22246.

Article  CAS  PubMed  Google Scholar 

Jang W, Park J, Kwon A, Choi H, Kim J, Lee GD, et al. CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia. Exp Mol Med. 2019;51:1–15. https://doi.org/10.1038/s12276-018-0195-x.

Article  CAS  PubMed  Google Scholar 

Xu N, Li YL, Zhou X, Cao R, Li H, Lu QS, et al. CDKN2 gene deletion as poor prognosis predictor involved in the progression of adult B-lineage acute lymphoblastic leukemia patients. J Cancer. 2015;6:1114–20. https://doi.org/10.7150/jca.11959.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu N, Li YL, Li X, Zhou X, Cao R, Li H, et al. Correlation between deletion of the CDKN2 gene and tyrosine kinase inhibitor resistance in adult Philadelphia chromosome-positive acute lymphoblastic leukemia. J Hematol Oncol. 2016;9:40. https://doi.org/10.1186/s13045-016-0270-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang Q, Yuan T, Li Y, Feng J, Gong X, Li Q, et al. Prognostic significance of copy number alterations detected by multi-link probe amplification of multiple genes in adult acute lymphoblastic leukemia. Oncol Lett. 2018;15:5359–67. https://doi.org/10.3892/ol.2018.7985.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ribera J, Zamora L, Morgades M, Vives S, Granada I, Montesinos P, et al. Molecular profiling refines minimal residual disease-based prognostic assessment in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2019;58:815–9. https://doi.org/10.1002/gcc.22788.

Article  CAS  PubMed  Google Scholar 

Genescà E, Lazarenkov A, Morgades M, Berbis G, Ruíz-Xivillé N, Gómez-Marzo P, et al. Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia. J Hematol Oncol. 2018;11:96. https://doi.org/10.1186/s13045-018-0639-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang HP, Zhou YL, Huang X, Zhang Y, Qian JJ, Li JH, et al. CDKN2A deletions are associated with poor outcomes in 101 adults with T-cell acute lymphoblastic leukemia. Am J Hematol. 2021;96:312–9. https://doi.org/10.1002/ajh.26069.

Article  CAS  PubMed  Google Scholar 

Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–405. https://doi.org/10.1182/blood-2016-03-643544.

Article  CAS  PubMed  Google Scholar 

Alvarnas JC, Brown PA, Aoun P, Ballen KK, Bellam N, Blum W, et al. Acute lymphoblastic leukemia. J Natl Compr Canc Netw. 2012;10:858–914. https://doi.org/10.6004/jnccn.2012.0089.

Article  CAS  PubMed  Google Scholar 

A Chinese expert panel consensus on diagnosis and treatment of adult acute lymphoblastic leukemia. Zhonghua Xue Ye Xue Za Zhi. 2012;33:789–92. https://doi.org/10.3760/cma.j.issn.0253-2727.2012.09.028.

Huang K, Dai M, Li Q, Liu N, Lin D, Wang Q, et al. Early T-cell precursor leukemia has a higher risk of induction-related infection among T-cell acute lymphoblastic leukemia in adult. Mediators Inflamm. 2020;2020:8867760. https://doi.org/10.1155/2020/8867760.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang XH, Chen J, Han MZ, Huang H, Jiang EL, Jiang M, et al. The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update. J Hematol Oncol. 2021;14:145. https://doi.org/10.1186/s13045-021-01159-2.

Article  PubMed  PubMed Central  Google Scholar 

Qi HZ, Xu J, Yang QQ, Lin R, Wang ZX, Zhao K, et al. Effect of pediatric- versus adult-type chemotherapy regimens on outcomes of allogeneic hematopoietic stem cell transplants for adult T-cell acute lymphoblastic leukemia in first complete remission. Bone Marrow Transpl. 2022;57:1704–11. https://doi.org/10.1038/s41409-022-01796-2.

Article  CAS  Google Scholar 

Yu S, Huang F, Fan Z, Xuan L, Nie D, Xu Y, et al. Haploidentical versus HLA-matched sibling transplantation for refractory acute leukemia undergoing sequential intensified conditioning followed by DLI: an analysis from two prospective data. J Hematol Oncol. 2020;13:18. https://doi.org/10.1186/s13045-020-00859-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu S, Huang F, Wang Y, Xu Y, Yang T, Fan Z, et al. Haploidentical transplantation might have superior graft-versus-leukemia effect than HLA-matched sibling transplantation for high-risk acute myeloid leukemia in first complete remission: a prospective multicentre cohort study. Leukemia. 2020;34:1433–43. https://doi.org/10.1038/s41375-019-0686-3.

Article  CAS  PubMed  Google Scholar 

Wang Y, Liu QF, Lin R, Yang T, Xu YJ, Mo XD, et al. Optimizing antithymocyte globulin dosing in haploidentical hematopoietic cell transplantation: long-term follow-up of a multicenter, randomized controlled trial. Sci Bull (Beijing). 2021;66:2498–505. https://doi.org/10.1016/j.scib.2021.06.002.

Article  CAS  PubMed  Google Scholar 

Zhao XS, Liu YR, Xu LP, Wang Y, Zhang XH, Chen H, et al. Minimal residual disease status determined by multiparametric flow cytometry pretransplantation predicts the outcome of patients with ALL receiving unmanipulated haploidentical allografts. Am J Hematol. 2019;94:512–21. https://doi.org/10.1002/ajh.25417.

Article  PubMed  Google Scholar 

Brothman AR, Persons DL, Shaffer LG. Nomenclature evolution: changes in the ISCN from the 2005 to the 2009 edition. Cytogenet Genome Res. 2009;127:1–4. https://doi.org/10.1159/000279442.

Article  CAS  PubMed  Google Scholar 

Wang Y, Chen G, Cao R, Li J, He L, Guo X, et al. Allogeneic hematopoietic stem cell transplantation improves the prognosis of p16-deleted adult patients with acute lymphoblastic leukemia. Pharmacogenomics. 2017;18:77–84. https://doi.org/10.2217/pgs-2016-0075.

Article  CAS  PubMed  Google Scholar 

Austin PC, Fine JP. Practical recommendations for reporting Fine-Gray model analyses for competing risk data. Stat Med. 2017;36:4391–400. https://doi.org/10.1002/sim.7501.

Article  PubMed  PubMed Central  Google Scholar 

Liggett WH Jr., Sidransky D. Role of the p16 tumor suppressor gene in cancer. J Clin Oncol. 1998;16:1197–206. https://doi.org/10.1200/jco.1998.16.3.1197.

Article  CAS  PubMed  Google Scholar 

Ling Y, Xu N, Zhao K, Han L, Zhang Q, Fan Z, et al. Allogeneic hematopoietic cell transplant overcomes the poor prognostic value of CDKN2 deletion in adult B-lineage acute lymphoblastic leukemia. Cancer Lett. 2021;510:59–66. https://doi.org/10.1016/j.canlet.2021.04.009.

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