van den Bent, M. J., Smits, M., Kros, J. M. & Chang, S. M. Diffuse infiltrating oligodendroglioma and astrocytoma. J. Clin. Oncol. 35, 2394–2401 (2017).
Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807–1812 (2008).
Article CAS PubMed PubMed Central Google Scholar
Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765–773 (2009).
Article CAS PubMed PubMed Central Google Scholar
Horbinski, C., Kofler, J., Kelly, L. M., Murdoch, G. H. & Nikiforova, M. N. Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues. J. Neuropathol. Exp. Neurol. 68, 1319–1325 (2009).
Article CAS PubMed Google Scholar
Capper, D., Zentgraf, H., Balss, J., Hartmann, C. & von Deimling, A. Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol. 118, 599–601 (2009).
Article CAS PubMed Google Scholar
Pusch, S. et al. Glioma IDH1 mutation patterns off the beaten track. Neuropathol. Appl. Neurobiol. 37, 428–430 (2011).
Article CAS PubMed Google Scholar
Ward, P. S. et al. Identification of additional IDH mutations associated with oncometabolite R(-)-2-hydroxyglutarate production. Oncogene 31, 2491–2498 (2012).
Article CAS PubMed Google Scholar
Gupta, R. et al. Expanding the spectrum of IDH1 mutations in gliomas. Mod. Pathol. 26, 619–625 (2013).
Article CAS PubMed Google Scholar
Ganz, J. et al. Rates and patterns of clonal oncogenic mutations in the normal human brain. Cancer Discov. 12, 172–185 (2022).
Article CAS PubMed Google Scholar
Louis, D. N. et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 23, 1231–1251 (2021).
Article CAS PubMed PubMed Central Google Scholar
Rudà, R., Bello, L., Duffau, H. & Soffietti, R. Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments. Neuro Oncol. 14, 55–64 (2012).
Weller, M. et al. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat. Rev. Clin. Oncol. 18, 170–186 (2021).
Miller, J. J. et al. Isocitrate dehydrogenase (IDH) mutant gliomas: a Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro Oncol. 25, 4–25 (2023).
Article CAS PubMed Google Scholar
Baumert, B. G. et al. Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study. Lancet Oncol. 17, 1521–1532 (2016).
Article CAS PubMed PubMed Central Google Scholar
Buckner, J. C. et al. Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma. N. Engl. J. Med. 374, 1344–1355 (2016).
Article CAS PubMed PubMed Central Google Scholar
Douw, L. et al. Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up. Lancet Neurol. 8, 810–818 (2009).
Johnson, B. E. et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343, 189–193 (2014).
Article CAS PubMed Google Scholar
DiNardo, C. D. et al. Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML. N. Engl. J. Med. 378, 2386–2398 (2018).
Article CAS PubMed Google Scholar
Abou-Alfa, G. K. et al. Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 21, 796–807 (2020).
Article CAS PubMed PubMed Central Google Scholar
Tap, W. D. et al. Phase I study of the mutant IDH1 inhibitor ivosidenib: safety and clinical activity in patients with advanced chondrosarcoma. J. Clin. Oncol. 38, 1693–1701 (2020).
Article CAS PubMed PubMed Central Google Scholar
Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739–744 (2009).
Article CAS PubMed PubMed Central Google Scholar
Figueroa, M. E. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553–567 (2010).
Article CAS PubMed PubMed Central Google Scholar
Xu, W. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17–30 (2010).
Chowdhury, R. et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 12, 463–469 (2011).
Article CAS PubMed PubMed Central Google Scholar
Koivunen, P. et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 483, 484–488 (2012).
Article CAS PubMed PubMed Central Google Scholar
Lu, C. et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483, 474–478 (2012).
Article CAS PubMed PubMed Central Google Scholar
Noushmehr, H. et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17, 510–522 (2010).
Article CAS PubMed PubMed Central Google Scholar
Lai, A. et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J. Clin. Oncol. 29, 4482–4490 (2011).
Article CAS PubMed PubMed Central Google Scholar
Carrillo, J. A. et al. Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma. Am. J. Neuroradiol. 33, 1349–1355 (2012).
Article CAS PubMed PubMed Central Google Scholar
Stockhammer, F. et al. IDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom. Seizure 21, 194–197 (2012).
Chen, R. et al. Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma. Proc. Natl Acad. Sci. USA 111, 14217–14222 (2014).
Article CAS PubMed PubMed Central Google Scholar
Waitkus, M. S. et al. Adaptive evolution of the GDH2 allosteric domain promotes gliomagenesis by resolving IDH1(R132H)-induced metabolic liabilities. Cancer Res. 78, 36–50 (2018).
Article CAS PubMed Google Scholar
Watanabe, T., Nobusawa, S., Kleihues, P. & Ohgaki, H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am. J. Pathol. 174, 1149–1153 (2009).
Article CAS PubMed PubMed Central Google Scholar
Wolter, M. et al. Oligodendroglial tumors frequently demonstrate hypermethylation of the CDKN2A (MTS1, p16INK4a), p14ARF, and CDKN2B (MTS2, p15INK4b) tumor suppressor genes. J. Neuropathol. Exp. Neurol. 60, 1170–1180 (2001).
Article CAS PubMed Google Scholar
Alonso, M. E. et al. Aberrant promoter methylation of multiple genes in oligodendrogliomas and ependymomas. Cancer Genet. Cytogenet. 144, 134–142 (2003).
Article CAS PubMed Google Scholar
Kuo, L. T. et al. Genetic and epigenetic alterations in primary-progressive paired oligodendroglial tumors. PLoS ONE 8, e67139 (2013).
Article CAS PubMed PubMed Central Google Scholar
Unruh, D. et al. Methylation and transcription patterns are distinct in IDH-mutant gliomas compared to other IDH-mutant cancers. Sci. Rep. 9, 8946 (2019).
留言 (0)