Available online 8 May 2024, 100997

miR-135b is involved in various biological processes underlying cardio-cerebrovascular diseases

Targeting miR-135b is an efficient therapeutic approach for cardio-cerebrovascular diseases

miR-135b exerts consistent protective effect against cerebrovascular diseases

Abnormal expression of miR-135b may provide early indications for the occurrence and development of cardio-cerebrovascular diseases

miR-135 is a highly conserved miRNA in mammals and includes miR-135a and miR-135b. Recent studies have shown that miR-135b is a key regulatory factor in cardio-cerebrovascular diseases. It is involved in regulating the pathological process of myocardial infarction, myocardial ischemia/reperfusion injury, cardiac hypertrophy, atrial fibrillation, diabetic cardiomyopathy, atherosclerosis, pulmonary hypertension, cerebral ischemia/reperfusion injury, Parkinson's disease, and Alzheimer's disease. Obviously, miR-135b is an emerging player in cardio-cerebrovascular diseases and is expected to be an important target for the treatment of cardio-cerebrovascular diseases. However, the crucial role of miR-135b in cardio-cerebrovascular diseases and its underlying mechanism of action has not been reviewed. Therefore, in this review, we aimed to comprehensively summarize the role of miR-135b and the signaling pathway mediated by miR-135b in cardio-cerebrovascular diseases. Drugs targeting miR-135b for the treatment of diseases and related patents, highlighting the importance of this target and its utility as a therapeutic target for cardio-cerebrovascular diseases, have been discussed.

miR-135b

Myocardial injury

Brain injury

Cardiovascular diseases

Cerebrovascular diseases

© 2024 The Authors. Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.