Available online 28 May 2024, 101012

Ferroptosis is regulated cell death by the iron-dependent accumulation of excessive lipid peroxidation

Novel therapeutic strategies targeting to epigenetic mechanisms for ferroptosis in cancer

Protein post-translational modifications in ferroptosis and cancer

Ferroptosis is a newly discovered form of cell death that is influenced by iron levels and is triggered by cellular metabolism and excessive lipid peroxidation. Epigenetic regulation plays a crucial role in the development and progression of diseases, making it essential to understand these mechanisms in order to identify potential targets for drug development and clinical treatment. The intersection of ferroptosis and epigenetics has opened up new avenues for research in drug development, offering innovative strategies for combating diseases. Recent studies have shown that epigenetic modifications can impact pathways related to ferroptosis, potentially leading to organ dysfunction. Despite the increasing focus on this relationship, the role of epigenetic regulation in drug development remains largely unexplored. This article explores current research on the interplay between epigenetic regulation and ferroptosis, delving into their regulatory mechanisms and discussing the effects of existing epigenetic modification regulators on diseases. Additionally, we highlight ongoing research on epigenetic factors involved in targeting ferroptosis in cancer, providing new insights for the development of cancer treatments.

Treatment strategies

Epigenetics

Ferroptosis

Epigenetic modifiers

© 2024 The Authors. Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.