Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Mariotto AB, Etzioni R, Hurlbert M, Penberthy L, Mayer M. Estimation of the number of women living with metastatic breast cancer in the United States. Cancer Epidemiol Biomarkers Prev. 2017;26(6):809–15.

Article  PubMed  PubMed Central  Google Scholar 

Waks AG, Winer EP. Breast cancer treatment: a review. JAMA. 2019;321(3):288–300.

Article  CAS  PubMed  Google Scholar 

Irvin W Jr, Muss HB, Mayer DK. Symptom management in metastatic breast cancer. Oncologist. 2011;16(9):1203–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sambi M, Qorri B, Harless W, Szewczuk MR. Therapeutic options for metastatic breast cancer. Breast cancer metastasis and drug resistance: challenges and progress. Adv Exp Med Biol. 2019;1152:131–72.

Article  CAS  PubMed  Google Scholar 

Ecclestone C, Chow R, Pulenzas N, Zhang L, Leahey A, Hamer J, DeAngelis C, Bedard G, McDonald R, Bhatia A, Ellis J. Quality of life and symptom burden in patients with metastatic breast cancer. Support Care Cancer. 2016;24:4035–43.

Article  PubMed  Google Scholar 

Mehralizadeh H, Nazari A, Oruji F, Roostaie M, Hosseininozari G, Yazdani O, Esbati R, Roudini K. Cytokine sustained delivery for cancer therapy; special focus on stem cell-and biomaterial-based delivery methods. Pathology-Research Pract. 2023 May;9:154528.

de Rezende LF, de Sá TH, Markozannes G, Rey-López JP, Lee IM, Tsilidis KK, Ioannidis JP, Eluf-Neto J. Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases. Br J Sports Med. 2018;52(13):826–33.

Article  PubMed  Google Scholar 

Chan DS, Abar L, Cariolou M, Nanu N, Greenwood DC, Bandera EV, McTiernan A, Norat T, World Cancer Research Fund International. Continuous Update Project—systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk. Cancer Causes Control. 2019;30:1183–200.

Article  PubMed  Google Scholar 

Kim CJ, Kang DH, Park JW. A meta-analysis of aerobic exercise interventions for women with breast cancer. West J Nurs Res. 2009;31(4):437–61.

Article  PubMed  Google Scholar 

Courneya KS. Exercise in cancer survivors: an overview of research. Med Sci Sports Exerc. 2003;35(11):1846–52.

Article  PubMed  Google Scholar 

Dieli-Conwright CM, Orozco BZ. Exercise after breast cancer treatment: current perspectives. Breast Cancer: Targets Therapy. 2015;7:353–62.

PubMed  Google Scholar 

Schmidt T, Jonat W, Wesch D, Oberg HH, Adam-Klages S, Keller L, Röcken C, Mundhenke C. Influence of physical activity on the immune system in breast cancer patients during chemotherapy. J Cancer Res Clin Oncol. 2018;144:579–86.

Article  PubMed  Google Scholar 

de Jesus Leite MA, Puga GM, Arantes FJ, Oliveira CJ, Cunha LM, Bortolini MJ, Penha-Silva N. Effects of combined and resistance training on the inflammatory profile in breast cancer survivors: a systematic review. Complement Ther Med. 2018;36:73–81.

Article  PubMed  Google Scholar 

Hashemi A, Bigdeli R, Shahnazari M, Oruji F, Fattahi S, Panahnejad E, Ghadri A, Movahedi-Asl E, Mahdavi-Ourtakand M, Asgary V, Baghbani-Arani F. Evaluation of inflammasome activation in peripheral blood mononuclear cells of hemodialysis treated patients with glomerulonephritis. Iran J Pharm Res. 2021;20(3):609.

CAS  PubMed  PubMed Central  Google Scholar 

Tolouei AE, Oruji F, Tehrani S, Rezaei S, Mozaffari A, Jahri M, Nasiri K. Gingival mesenchymal stem cell therapy, immune cells, and immunoinflammatory application. Mol Biol Rep. 2023;50(12):10461–9.

Article  CAS  PubMed  Google Scholar 

Hojman P. Exercise protects from cancer through regulation of immune function and inflammation. Biochem Soc Trans. 2017;45(4):905–11.

Article  CAS  PubMed  Google Scholar 

Dethlefsen C, Pedersen KS, Hojman P. Every exercise bout matters: linking systemic exercise responses to breast cancer control. Breast Cancer Res Treat. 2017;162:399–408.

Article  PubMed  Google Scholar 

Shabani S, Moghadam MF, Gargari SL. Isolation and characterization of a novel GRP78-specific single-chain variable fragment (scFv) using ribosome display method. Med Oncol. 2021;38(9):115.

Article  CAS  PubMed  Google Scholar 

McTiernan A, Kooperberg C, White E, Wilcox S, Coates R, Adams-Campbell LL, Woods N, Ockene J. Recreational physical activity and the risk of breast cancer in postmenopausal women: the women’s Health Initiative Cohort Study. JAMA. 2003;290(10):1331–6.

Article  CAS  PubMed  Google Scholar 

Eliassen AH, Hankinson SE, Rosner B, Holmes MD, Willett WC. Physical activity and risk of breast cancer among postmenopausal women. Arch Intern Med. 2010;170(19):1758–64.

Article  PubMed  PubMed Central  Google Scholar 

Xu Y, Rogers CJ. Physical activity and breast cancer prevention: possible role of immune mediators. Front Nutr. 2020;7:557997.

Article  PubMed  PubMed Central  Google Scholar 

Friebel TM, Domchek SM, Rebbeck TR. Modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: a systematic review and meta-analysis. J Natl Cancer Inst. 2014;106(6):091.

Article  Google Scholar 

Wu Y, Zhang D, Kang S. Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat. 2013;137:869–82.

Article  PubMed  Google Scholar 

Brown JC, Winters-Stone K, Lee A, Schmitz KH. Cancer, physical activity, and exercise. Compr Physiol. 2012;2(4):2775–809.

Article  PubMed  PubMed Central  Google Scholar 

Oruji F, Baghbani Arani F, Mahdavi Ortakand M. Evaluation of the gene expression of IL-1β and Casp-1 related to inflammation process in glomerulonephritis patients. J Anim Environ. 2018;10(3):477–82.

Google Scholar 

de Boer MC, Wörner EA, Verlaan D, van Leeuwen PA. The mechanisms and effects of physical activity on breast cancer. Clin Breast Cancer. 2017;17(4):272–8.

Article  PubMed  Google Scholar 

van Doorslaer S, Deldicque L. The regulation of the metastatic cascade by physical activity: a narrative review. Cancers. 2020;12(1):153.

Article  Google Scholar 

Alvarado A, Gil da Costa RM, Faustino-Rocha AI, Ferreira R, Lopes C, Oliveira PA, Colaço B. Effects of exercise training on breast cancer metastasis in a rat model. Int J Exp Pathol. 2017;98(1):40–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smeda M, Przyborowski K, Proniewski B, Zakrzewska A, Kaczor D, Stojak M, Buczek E, Nieckarz Z, Zoladz JA, Wietrzyk J, Chlopicki S. Breast cancer pulmonary metastasis is increased in mice undertaking spontaneous physical training in the running wheel; a call for revising beneficial effects of exercise on cancer progression. Am J Cancer Res. 2017;7(9):1926.

CAS  PubMed  PubMed Central  Google Scholar 

Isazadeh H, Oruji F, Shabani S, Behroozi J, Nasiri H, Isazadeh A, Akbari M. Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities. Mol Biol Rep. 2023;50(11):9529–43.

Article  CAS  PubMed  Google Scholar 

Goh J, Kirk EA, Lee SX, Ladiges WC. Exercise, physical activity and breast cancer: the role of tumor-associated macrophages. Eexrc Immunol Rev. 2012;18:158–76.

Google Scholar 

Zhang D, Tan X, Tang N, Huang F, Chen Z, Shi G. Review of Research on the role of Irisin in Tumors. OncoTargets Ther. 2020;13:4423–30.

Article  CAS  Google Scholar 

Provatopoulou X, Georgiou GP, Kalogera E, Kalles V, Matiatou MA, Papapanagiotou I, Sagkriotis A, Zografos GC, Gounaris A. Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics. BMC Cancer. 2015;15:898–907.

Article  PubMed  PubMed Central  Google Scholar 

Zhang ZP, Zhang XF, Li H, Liu TJ, Zhao QP, Huang LH, Cao ZJ, He LM, Hao DJ. Serum irisin associates with breast cancer to spinal metastasis. Medicine. 2018;97(17):e0524.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saxena NK, Sharma D. Metastasis suppression by adiponectin: LKB1 rises up to the challenge. Cell Adhes Migr. 2010;4(3):358–62.

Article  Google Scholar 

Ray A, Cleary MP. The potential role of leptin in tumor invasion and metastasis. Cytokine Growth Factor Rev. 2017;38:80–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ham B, Fernandez MC, D’costa Z, Brodt P. The diverse roles of the TNF Axis in Cancer Progression and Metastasis. Trends Cancer Res. 2016;11:1–27.

PubMed  PubMed Central  Google Scholar 

Papadopetraki A, Maridaki M, Zagouri F, Dimopoulos MA, Koutsilieris M, Philippou A. Physical exercise restrains cancer progression through muscle-derived factors. Cancers. 2022;14(8):1892.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Loh HY, Norman BP, Lai KS, Rahman NM, Alitheen NB, Osman MA. The regulatory role of microRNAs in breast cancer.