Chen Z-Q, Zuo X-L, Cai J, et al. Hypoxia-associated circPRDM4 promotes immune escape via HIF-1α regulation of PD-L1 in hepatocellular carcinoma. Exp Hematol Oncol. 2023;12(1):17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gentile D, Donadon M, Lleo A, et al. Surgical treatment of hepatocholangiocarcinoma: a systematic review. Liver Cancer. 2020;9(1):15–27.

Article  PubMed  Google Scholar 

Marques HP, Da Silva SG, de Martin E, et al. Emerging biomarkers in HCC patients: current status. Int J Surg. 2020;82:70–6.

Article  Google Scholar 

Wang Y, Deng B. Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers. Cancer Metastasis Rev. 2023;42(3):629–52.

Article  PubMed  Google Scholar 

Xing M, Wang X, Kiken RA, et al. Immunodiagnostic biomarkers for hepatocellular carcinoma (HCC): the first step in detection and treatment. Int J Mol Sci. 2021;22(11):6139.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao M, Qin M, Liu L, et al. Exosomal microRNA profiling revealed enhanced autophagy suppression and anti-tumor effects of a combination of compound Phyllanthus urinaria and lenvatinib in hepatocellular carcinoma. Phytomed Int J Phytother Phytopharm. 2024;122:155091.

CAS  Google Scholar 

Liu P, Kong L, Liu Y, et al. A key driver to promote HCC: cellular crosstalk in tumor microenvironment. Front Oncol. 2023;13:1135122.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Wei C. Advances in the early diagnosis of hepatocellular carcinoma. Genes Dis. 2020;7(3):308–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim DY. New systemic therapies for advanced hepatocellular carcinoma. Korean J Gastroenterol. 2019;73(1):10–5.

Article  PubMed  Google Scholar 

Huang A, Yang X-R, Chung W-Y, et al. Targeted therapy for hepatocellular carcinoma. Signal Transduct Target Ther. 2020;5(1):146.

Article  PubMed  PubMed Central  Google Scholar 

Luo D, Wang Z, Wu J, et al. The role of hypoxia inducible factor-1 in hepatocellular carcinoma. Biomed Res Int. 2014;2014:409272.

Article  PubMed  PubMed Central  Google Scholar 

Li Q, Ni Y, Zhang L, et al. HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation. Signal Transduct Target Ther. 2021;6(1):76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cramer T, Vaupel P. Severe hypoxia is a typical characteristic of human hepatocellular carcinoma: scientific fact or fallacy? J Hepatol. 2022;76(4):975–80.

Article  CAS  PubMed  Google Scholar 

Povero D, Chen Y, Johnson SM, et al. HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia. J Hepatol. 2023;79(2):378–93.

Article  CAS  PubMed  Google Scholar 

Cui C-P, Wong CC-L, Kai AK-L, et al. SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut. 2017;66(12):2149–59.

Article  CAS  PubMed  Google Scholar 

Lin W, Li S, Meng Y, et al. UDCA inhibits hypoxic hepatocellular carcinoma cell-induced angiogenesis through suppressing HIF-1α/VEGF/IL-8 intercellular signaling. Front Pharmacol. 2021;12:755394.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu Y, Mackowiak B, Feng D, et al. MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression. Gut. 2023;72(10):1942–58.

Article  CAS  PubMed  Google Scholar 

Ling S, Shan Q, Zhan Q, et al. USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation. Gut. 2020;69(7):1322–34.

Article  CAS  PubMed  Google Scholar 

Wu X-Z, Xie G-R, Chen D. Hypoxia and hepatocellular carcinoma: the therapeutic target for hepatocellular carcinoma. J Gastroenterol Hepatol. 2007;22(8):1178–82.

Article  CAS  PubMed  Google Scholar 

Yan H, He N, He S. HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription. Biochem Biophys Res Commun. 2022;608:170–6.

Article  CAS  PubMed  Google Scholar 

Méndez-Blanco C, Fondevila F, García-Palomo A, et al. Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors. Exp Mol Med. 2018;50(10):1–9.

Article  PubMed  Google Scholar 

Herman AB, Tsitsipatis D, Gorospe M. Integrated lncRNA function upon genomic and epigenomic regulation. Mol Cell. 2022;82(12):2252–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Li Y, Ma Y, et al. Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress. J Exp Clin Cancer Res. 2018;37(1):216.

Article  PubMed  PubMed Central  Google Scholar 

Hu M, Fu Q, Jing C, et al. LncRNA HOTAIR knockdown inhibits glycolysis by regulating miR-130a-3p/HIF1A in hepatocellular carcinoma under hypoxia. Biomed Pharmacother. 2020;125:109703.

Article  CAS  PubMed  Google Scholar 

Li X, Li Y, Bai S, et al. NR2F1-AS1/miR-140/HK2 axis regulates hypoxia-induced glycolysis and migration in hepatocellular carcinoma. Cancer Manag Res. 2021;13:427–37.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun L, Wang L, Chen T, et al. LncRNA RUNX1-IT1 which is downregulated by hypoxia-driven histone deacetylase 3 represses proliferation and cancer stem-like properties in hepatocellular carcinoma cells. Cell Death Dis. 2020;11(2):95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia A, Yuan W, Wang Q, et al. The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription. Nature Cancer. 2022;3(2):203–18.

Article  CAS  PubMed  Google Scholar 

Chen S-P, Zhu G-Q, Xing X-X, et al. LncRNA USP2-AS1 promotes hepatocellular carcinoma growth by enhancing YBX1-mediated HIF1α protein translation under hypoxia. Front Oncol. 2022;12:882372.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun W, Lei X, Lu Q, et al. LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis. Pathol Res Pract. 2023;243:154377.

Article  CAS  PubMed  Google Scholar 

Tang P, Qu W, Wang T, et al. Identifying a hypoxia-related long non-coding RNAs signature to improve the prediction of prognosis and immunotherapy response in hepatocellular carcinoma. Front Genet. 2021;12:785185.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang R, Tang J, Chen Y, et al. The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion. Nat Commun. 2017;8:15129.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Z, Zhou F, Yang Y, et al. Lnc-PCDH9-13:1 Is a hypersensitive and specific biomarker for early hepatocellular carcinoma. EBioMedicine. 2018;33:57–67.

Article  PubMed  PubMed Central  Google Scholar 

Fares J, Fares MY, Khachfe HH, et al. Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct Target Ther. 2020;5(1):28.

Article  PubMed  PubMed Central  Google Scholar 

Gerstberger S, Jiang Q, Ganesh K. Metastasis. Cell. 2023;186(8):1564–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganesh K, Massagué J. Targeting metastatic cancer. Nat Med. 2021;27(1):34–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma X-L, Shen M-N, Hu B, et al. CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis. J Hematol Oncol. 2019;12(1):37.

Article  PubMed  PubMed Central  Google Scholar 

Dutta R, Mahato RI. Recent advances i