Horm Metab Res
DOI: 10.1055/a-2294-6749
Original Article: Endocrine Care
Juan Zhang
1
Department of Rheumatology, Lanzhou University Second Hospital,
Lanzhou, Gansu, China
,
Jingjing Tian
1
Department of Rheumatology, Lanzhou University Second Hospital,
Lanzhou, Gansu, China
,
Xiaoyuan Wang
1
Department of Rheumatology, Lanzhou University Second Hospital,
Lanzhou, Gansu, China
,
Haili Shen
1
Department of Rheumatology, Lanzhou University Second Hospital,
Lanzhou, Gansu, China
› Author Affiliations
Funding Information
Innovation Base and Talent Plan of Gansu Province
— Grant number 21JR7RA437
Science and Technology Project of Gansu Province —
Grant number 21JR1RA134
Cuiying Scientific and Technological Innovation
Program of Lanzhou University Second Hospital (CY2021-MS-A18).
› Further Information
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Abstract
Serum uric acid (UA) and homocysteine (Hcy) are potential biomarkers of systemic
lupus erythematosus (SLE). In this study, the expressions of UA and Hcy in SLE
patients and the predictive value of these two parameters for lupus nephritis
(LN) were studied. A total of 476 SLE patients were recruited to this
case-control study, of which 176 SLE patients diagnosed with LN and 300 without
LN. Serum UA and Hcy levels were analyzed. Multivariate logistic regression
analysis was used to evaluate the relationship between serum UA and Hcy and LN.
The receiver operating characteristic (ROC) curves were used to predict the role
of combination of serum UA and Hcy in LN. We found that serum UA and Hcy levels
in SLE patients with LN were significantly higher than those in controls
(p<0.05). Multivariate logistic regressions showed that serum UA (OR+=+1.003,
95+% CI: 1.001–1.006, p+=+0.003), apolipoprotein B (Apo B) (OR+=+21.361, 95+%
CI: 2.312–195.373, p+=+0.007) and Hcy (OR+=+1.042, 95+% CI: 1.011–1.080,
p+=+0.014) were independent markers of LN. Combined serum UA and Hcy revealed a
better result (AUC+=+0.718, 95+% CI: 0.670–0.676, p<0.001) in prediction of
LN compared to that of the serum UA (AUC+=+0.710) and Hcy (AUC+=+0.657)
independently. In conclusion, serum UA and Hcy could be predictive biomarkers of
LN, and joint detection of serum UA and Hcy might be useful in the clinical
setting.
Keywords
biomarkers -
homocysteine -
lupus nephritis -
uric acid -
systemic lupus erythematosus
Publication History
Received: 26 May 2023
Accepted after revision: 11 March 2024
Article published online:
06 May 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart,
Germany
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