Horm Metab Res 2024; 56(11): 761-769
DOI: 10.1055/a-2411-9344
Lin Sun
1
Department of Endocrinology and Metabolism, The First
Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Xiaokun Gang
1
Department of Endocrinology and Metabolism, The First
Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Fei Li
1
Department of Endocrinology and Metabolism, The First
Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Weiying Guo
1
Department of Endocrinology and Metabolism, The First
Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Mengzhao Cui
1
Department of Endocrinology and Metabolism, The First
Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
,
Guixia Wang
1
Department of Endocrinology and Metabolism, The First
Hospital of Jilin University, Changchun, China (Ringgold ID: RIN117971)
› Author Affiliations
Funding Information
Youth Development Fund of the First Hospital of Jilin University |
04039890001 | National Natural Science Foundation of China |
82100871
› Further Information
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Abstract
Osteoarthritis (OA), a chronic joint disease characterized by primary or secondary
degeneration of articular cartilage and bone dysplasia, is associated with various
risk factors and is the leading cause of musculoskeletal pain and disability,
severely impacting the quality of life. Growth hormone (GH), secreted by the
anterior pituitary gland, is essential in mediating the growth and development of
bone and cartilage. Reportedly, osteoarthritis increases, and the growth hormone
decreases with age. A negative correlation between GH and OA suggests that GH may be
related to the occurrence and development of OA. Considering that abnormal growth
hormone levels can lead to many diseases related to bone growth, we focus on the
relationship between GH and OA. In this review, we will explain the effects of GH on
the growth and deficiency of bone and cartilage based on the local pathological
changes of osteoarthritis. In addition, the potential feasibility of treating OA
with GH will be further explored and summarized.
Keywords
growth hormone -
cancer -
IGF-1 -
osteoarthritis -
hormone regulation
Publication History
Received: 23 January 2024
Accepted after revision: 01 September 2024
Article published online:
07 November 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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