Goto M, Al-Hasan MN. Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe. Clin Microbiol Infect. 2013;19(6):501–9.

Article  CAS  PubMed  Google Scholar 

Murray CJ, Ikuta KS, Sharara F, Swetschinski L, Aguilar GR, Gray A, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 2022;399(10325):629–55.

Article  CAS  Google Scholar 

Digiovine B, Chenoweth C, Watts C, Higgins M. The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit. Am J Respir Crit Care Med. 1999;160(3):976–81.

Article  CAS  PubMed  Google Scholar 

Riu M, Chiarello P, Terradas R, Sala M, Garcia-Alzorriz E, Castells X, et al. Cost attributable to nosocomial bacteremia: analysis according to microorganism and antimicrobial sensitivity in a University Hospital in Barcelona. PLoS ONE. 2016;11(4): e0153076.

Article  PubMed  PubMed Central  Google Scholar 

Albrecht SJ, Fishman NO, Kitchen J, Nachamkin I, Bilker WB, Hoegg C, et al. Reemergence of gram-negative health care-associated bloodstream infections. Arch Intern Med. 2006;166(12):1289–94.

Article  PubMed  Google Scholar 

Diekema DJ, Hsueh PR, Mendes RE, Pfaller MA, Rolston KV, Sader HS, et al. The microbiology of bloodstream infection: 20-year trends from the SENTRY antimicrobial surveillance program. Antimicrob Agents Chemother. 2019;63(7):e00355-e419.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lai CC, Chen YH, Lin SH, Chung KP, Sheng WH, Ko WC, et al. Changing aetiology of healthcare-associated bloodstream infections at three medical centres in Taiwan, 2000–2011. Epidemiol Infect. 2014;142(10):2180–5.

Article  CAS  PubMed  Google Scholar 

Pfaller MA, Jones RN, Doern GV, Kugler K, Group TSP. Bacterial pathogens isolated from patients with bloodstream infection: frequencies of occurrence and antimicrobial susceptibility patterns from the SENTRY antimicrobial surveillance program (United States and Canada, 1997). Antimicrob Agents Chemother. 1998;42(7):1762–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pien BC, Sundaram P, Raoof N, Costa SF, Mirrett S, Woods CW, et al. The clinical and prognostic importance of positive blood cultures in adults. Am J Med. 2010;123(9):819–28.

Article  PubMed  Google Scholar 

Rodríguez-Créixems M, Alcalá L, Muñoz P, Cercenado E, Vicente T, Bouza E. Bloodstream infections: evolution and trends in the microbiology workload, incidence, and etiology, 1985–2006. Medicine. 2008;87(4):234.

Article  PubMed  Google Scholar 

Uslan DZ, Crane SJ, Steckelberg JM, Cockerill FR, St. Sauver JL, Wilson WR, et al. Age- and sex-associated trends in bloodstream infection: a population-based study in Olmsted county, Minnesota. Arch Int Med. 2007;167(8):834–9.

Article  Google Scholar 

Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39(3):309–17.

Article  PubMed  Google Scholar 

Yinnon AM, Butnaru A, Raveh D, Jerassy Z, Rudensky B. Klebsiella bacteraemia: community versus nosocomial infection. QJM. 1996;89(12):933–41.

Article  CAS  PubMed  Google Scholar 

Aydin M, Ergonul O, Azap A, Bilgin H, Aydin G, Cavus SA, et al. Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections. J Hosp Infect. 2018;98(3):260–3.

Article  CAS  PubMed  Google Scholar 

Kang CI, Kim SH, Bang JW, Kim HB, Kim NJ, Kim EC, et al. Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistance. J Korean Med Sci. 2006;21(5):816–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meatherall BL, Gregson D, Ross T, Pitout JDD, Laupland KB. Incidence, risk factors, and outcomes of Klebsiella pneumoniae bacteremia. Am J Med. 2009;122(9):866–73.

Article  PubMed  Google Scholar 

Qureshi ZA, Paterson DL, Potoski BA, Kilayko MC, Sandovsky G, Sordillo E, et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother. 2012;56(4):2108–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsay RW, Siu LK, Fung CP, Chang FY. Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection. Arch Intern Med. 2002;162(9):1021–7.

Article  PubMed  Google Scholar 

Xu L, Sun X, Ma X. Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae. Ann Clin Microbiol Antimicrob. 2017;29(16):18.

Article  Google Scholar 

Zarkotou O, Pournaras S, Tselioti P, Dragoumanos V, Pitiriga V, Ranellou K, et al. Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect. 2011;17(12):1798–803.

Article  CAS  PubMed  Google Scholar 

Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP, et al. Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med. 1991;115(8):585–90.

Article  CAS  PubMed  Google Scholar 

Lee CC, Lee NY, Yan JJ, Lee HC, Chen PL, Chang CM, et al. Bacteremia due to extended-spectrum-β-lactamase-producing enterobacter cloacae: role of carbapenem therapy. Antimicrob Agents Chemother. 2010;54(9):3551–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu C, Wang N, Lee C, Weng L, Tseng H, Liu C, et al. Nosocomial and community-acquired Enterobacter cloacae bloodstream infection: risk factors for and prevalence of SHV-12 in multiresistant isolates in a medical centre. J Hosp Infect. 2004;58(1):63–77.

Article  PubMed  Google Scholar 

Siedner M, Galar A, Guzman-Suarez B, Kubiak D, Baghdady N, Ferraro M, et al. Cefepime vs other antibacterial agents for the treatment of Enterobacter species bacteremia. Clin Infect Dis. 2014;58(11):1554–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harris P, Peri A, Pelecanos A, Hughes C, Paterson D, Ferguson J. Risk factors for relapse or persistence of bacteraemia caused by Enterobacter spp.: a case-control study. Antimicrob Resist Infect Control. 2017;6:1–8.

Article  Google Scholar 

Qureshi ZA, Paterson DL, Pakstis DL, Adams-Haduch JM, Sandkovsky G, Sordillo E, et al. Risk factors and outcome of extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infections. Int J Antimicrob Agents. 2011;37(1):26–32.

Article  CAS  PubMed  Google Scholar 

Chang EP, Chiang DH, Lin ML, Chen TL, Wang FD, Liu CY. Clinical characteristics and predictors of mortality in patients with Enterobacter aerogenes bacteremia. J Microbiol Immunol Infect. 2009;42(4):329–35.

PubMed  Google Scholar 

Bascomb S, Lapage SP, Willcox WR, Curtis MA. Numerical classification of the tribe Klebsielleae. Microbiology. 1971;66(3):279–95.

CAS  Google Scholar 

Chavda KD, Chen L, Fouts DE, Sutton G, Brinkac L, Jenkins SG, et al. Comprehensive genome analysis of carbapenemase-producing Enterobacter spp.: new insights into phylogeny, population structure, and resistance mechanisms. mBio. 2016;7(6):e02093-16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diene SM, Merhej V, Henry M, El Filali A, Roux V, Robert C, et al. The rhizome of the multidrug-resistant Enterobacter aerogenes genome reveals how new ‘killer bugs’ are created because of a sympatric lifestyle. Mol Biol Evol. 2013;30(2):369–83.

Article  CAS  PubMed  Google Scholar 

Izard D, Gavini F, Trinel PA, Krubwa F, Leclerc H. Contribution of DNA–DNA hybridization to the transfer of Enterobacter aerogenes to the Genus Klebsiella as K mobilis. Zentralblatt für Bakteriologie: I Abt Originale C: Allgemeine, angewandte und ökologische Mikrobiologie. 1980;1(3):257–63.

Article  CAS  Google Scholar 

Davin-Regli A, Lavigne JP, Pagès JM. Enterobacter spp.: update on taxonomy, clinical aspects, and emerging antimicrobial resistance. Clin Microbiol Rev. 2019;32(4):e00002-19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tindall BJ, Sutton G, Garrity GM. Enterobacter aerogenes Hormaeche and Edwards 1960 (Approved Lists 1980) and Klebsiella mobilis Bascomb et al. 1971 (Approved Lists 1980) share the same nomenclatural type (ATCC 13048) on the Approved Lists and are homotypic synonyms, with consequences for the name Klebsiella mobilis Bascomb et al. 1971 (Approved Lists 1980). Int J Syst Evolut Microbiol. 2017;67(2):502–4.

Article  CAS  Google Scholar 

Azevedo PAA, Furlan JPR, Oliveira-Silva M, Nakamura-Silva R, Gomes CN, Costa KRC, et al. Detection of virulence and β-lactamase encoding genes in Enterobacter aerogenes and Enterobacter cloacae clinical isolates from Brazil. Braz J Microbiol. 2018;49(Suppl 1):224–8.

Article  PubMed  PubMed Central  Google Scholar 

Compain F, Babosan A, Brisse S, Genel N, Audo J, Ailloud F, et al. Multiplex PCR for detection of seven virulence factors and K1/K2 capsular serotypes of Klebsiella pneumoniae. J Clin Microbiol. 2014;52(12):4377–80.

Article  PubMed  PubMed Central  Google Scholar 

El Fertas-Aissani R, Messai Y, Aloua