Liu J, Dang H, Wang XW. The significance of intertumor and intratumor heterogeneity in liver cancer. Exp Mol Med. 2018;50:e416.
Article PubMed PubMed Central Google Scholar
Marusyk A, Janiszewska M, Polyak K. Intratumor Heterogeneity: the Rosetta Stone of Therapy Resistance. Cancer Cell. 2020;37:471–84.
Article CAS PubMed PubMed Central Google Scholar
Sharma A, Merritt E, Hu X, Cruz A, Jiang C, Sarkodie H, et al. Non-genetic Intra-tumor heterogeneity is a major predictor of phenotypic heterogeneity and Ongoing Evolutionary dynamics in Lung tumors. Cell Rep. 2019;29:2164–e21745.
Article CAS PubMed PubMed Central Google Scholar
Okegawa T, Morimoto M, Nishizawa S, Kitazawa S, Honda K, Araki H, et al. Intratumor Heterogeneity in primary kidney Cancer revealed by metabolic profiling of multiple spatially separated samples within tumors. EBioMedicine. 2017;19:31–8.
Article PubMed PubMed Central Google Scholar
Marjanovic ND, Weinberg RA, Chaffer CL. Cell plasticity and heterogeneity in cancer. Clin Chem. 2013;59:168–79.
Article CAS PubMed Google Scholar
Yabo YA, Niclou SP, Golebiewska A. Cancer cell heterogeneity and plasticity: a paradigm shift in glioblastoma. Neuro Oncol. 2022;24:669–82.
Article CAS PubMed Google Scholar
Yuan S, Norgard RJ, Stanger BZ. Cellular Plasticity in Cancer. Cancer Discov. 2019;9:837–51.
Article CAS PubMed PubMed Central Google Scholar
Xu X, Peng Q, Jiang X, Tan S, Yang Y, Yang W, et al. Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential. Exp Mol Med. 2023;55:1357–70.
Article CAS PubMed PubMed Central Google Scholar
Yang M, Park JY. DNA methylation in promoter region as biomarkers in prostate cancer. Methods Mol Biol. 2012;863:67–109.
Article CAS PubMed PubMed Central Google Scholar
Moarii M, Boeva V, Vert J-P, Reyal F. Changes in correlation between promoter methylation and gene expression in cancer. BMC Genomics. 2015;16:873.
Article PubMed PubMed Central Google Scholar
Jin J, Wu X, Yin J, Li M, Shen J, Li J, et al. Identification of genetic mutations in Cancer: challenge and opportunity in the New era of targeted therapy. Front Oncol. 2019;9:263.
Article PubMed PubMed Central Google Scholar
Dasari K, Somarelli JA, Kumar S, Townsend JP. The somatic molecular evolution of cancer: mutation, selection, and epistasis. Prog Biophys Mol Biol. 2021;165:56–65.
Article CAS PubMed PubMed Central Google Scholar
da Silva-Diz V, Lorenzo-Sanz L, Bernat-Peguera A, Lopez-Cerda M, Muñoz P. Cancer cell plasticity: impact on tumor progression and therapy response. Semin Cancer Biol. 2018;53:48–58.
Pérez-González A, Bévant K, Blanpain C. Cancer cell plasticity during tumor progression, metastasis and response to therapy. Nat Cancer. 2023;4:1063–82.
Article PubMed PubMed Central Google Scholar
Wu M, Zhang X, Zhang W, Chiou YS, Qian W, Liu X, et al. Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis. Nat Commun. 2022;13:1371.
Article CAS PubMed PubMed Central Google Scholar
Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson NA, et al. Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance. Nat Cancer. 2022;3:1071–87.
Article CAS PubMed PubMed Central Google Scholar
Wang X, Jung Y-S, Jun S, Lee S, Wang W, Schneider A, et al. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun. 2016;7:10633.
Article CAS PubMed PubMed Central Google Scholar
Ambrosini G, Dalla Pozza E, Fanelli G, Di Carlo C, Vettori A, Cannino G, et al. Progressively de-differentiated pancreatic Cancer cells shift from Glycolysis to oxidative metabolism and Gain a quiescent stem state. Cells. 2020;9:1572.
Article CAS PubMed PubMed Central Google Scholar
Carmona-Carmona CA, Dalla Pozza E, Ambrosini G, Cisterna B, Palmieri M, Decimo I, et al. Mitochondrial elongation and OPA1 play crucial roles during the Stemness Acquisition process in pancreatic ductal adenocarcinoma. Cancers (Basel). 2022;14:3432.
Article CAS PubMed Google Scholar
Lee SH, Oh S-Y, Do SI, Lee HJ, Kang HJ, Rho YS, et al. SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma. Br J Cancer. 2014;111:2122–30.
Article PubMed PubMed Central Google Scholar
Bono B, Ostano P, Peritore M, Gregnanin I, Belgiovine C, Liguori M, et al. Cells with stemness features are generated from in vitro transformed human fibroblasts. Sci Rep. 2018;8:13838.
Article PubMed PubMed Central Google Scholar
Kumon K, Afify SM, Hassan G, Ueno S, Monzur S, Nawara HM, et al. Differentiation of cancer stem cells into erythroblasts in the presence of CoCl2. Sci Rep. 2021;11:23977.
Article CAS PubMed PubMed Central Google Scholar
Musella M, Guarracino A, Manduca N, Galassi C, Ruggiero E, Potenza A, et al. Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B. Nat Immunol. 2022;23:1379–92.
Article CAS PubMed PubMed Central Google Scholar
Li Y, Zhang H, Merkher Y, Chen L, Liu N, Leonov S, et al. Recent advances in therapeutic strategies for triple-negative breast cancer. J Hematol Oncol. 2022;15:121.
Article CAS PubMed PubMed Central Google Scholar
Lee K-L, Kuo Y-C, Ho Y-S, Huang Y-H. Triple-negative breast Cancer: current understanding and future therapeutic breakthrough Targeting Cancer Stemness. Cancers (Basel). 2019;11:1334.
Article CAS PubMed Google Scholar
Zhou Y, Xia L, Wang H, Oyang L, Su M, Liu Q, et al. Cancer stem cells in progression of colorectal cancer. Oncotarget. 2018;9:33403–15.
Kalantari E, Taheri T, Fata S, Abolhasani M, Mehrazma M, Madjd Z, et al. Significant co-expression of putative cancer stem cell markers, EpCAM and CD166, correlates with tumor stage and invasive behavior in colorectal cancer. World J Surg Oncol. 2022;20:15.
Article PubMed PubMed Central Google Scholar
Basu S, Cheriyamundath S, Ben-Ze’ev A. Cell-cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis. F1000Res. 2018;7:F1000 Faculty Rev-1488.
Jang G-B, Kim J-Y, Cho S-D, Park K-S, Jung J-Y, Lee H-Y, et al. Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype. Sci Rep. 2015;5:12465.
Article PubMed PubMed Central Google Scholar
Shan S, Lv Q, Zhao Y, Liu C, Sun Y, Xi K, et al. Wnt/β-catenin pathway is required for epithelial to mesenchymal transition in CXCL12 over expressed breast cancer cells. Int J Clin Exp Pathol. 2015;8:12357–67.
CAS PubMed PubMed Central Google Scholar
Kim BN, Ahn DH, Kang N, Yeo CD, Kim YK, Lee KY, et al. TGF-β induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer. Sci Rep. 2020;10:10597.
Article CAS PubMed PubMed Central Google Scholar
Natsuizaka M, Whelan KA, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran PM, et al. Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma. Nat Commun. 2017;8:1758.
Article PubMed PubMed Central Google Scholar
Kang A-R, Kim J-L, Kim Y, Kang S, Oh S-C, Park JK. A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT. Cancer Gene Ther. 2023.
Puisieux A, Brabletz T, Caramel J. Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol. 2014;16:488–94.
Article CAS PubMed Google Scholar
Fazilaty H, Rago L, Kass Youssef K, Ocaña OH, Garcia-Asencio F, Arcas A, et al. A gene regulatory network to control EMT programs in development and disease. Nat Commun. 2019;10:5115.
Article PubMed PubMed Central Google Scholar
Tan Y, Li J, Zhao G, Huang K-C, Cardenas H, Wang Y, et al. Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells. Nat Commun. 2022;13:4554.
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