Horm Metab Res
DOI: 10.1055/a-2299-2914
Original Article: Endocrine Care
1
Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu
University, Kunshan, China
,
Menghuan Wu
2
Department of Cardiology, Xuyi People's Hospital, Xuyi,
China
,
Han Yan
3
Department of Endocrinology, Affiliated Wujin Hospital of Jiangsu
University, Wujin Clinical College of Xuzhou Medical University, Changzhou,
China
,
Shao Zhong
1
Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu
University, Kunshan, China
,
Ruijun Xu
3
Department of Endocrinology, Affiliated Wujin Hospital of Jiangsu
University, Wujin Clinical College of Xuzhou Medical University, Changzhou,
China
,
Zhiyong Zhao
3
Department of Endocrinology, Affiliated Wujin Hospital of Jiangsu
University, Wujin Clinical College of Xuzhou Medical University, Changzhou,
China
,
Qichao Yang
3
Department of Endocrinology, Affiliated Wujin Hospital of Jiangsu
University, Wujin Clinical College of Xuzhou Medical University, Changzhou,
China
› Author Affiliations
Funding Information
The Science and Technology Project of Changzhou Health Commission — WZ202226
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Abstract
Remnant cholesterol (RC) is closely related to metabolic diseases. Our study aims
to explore the relationship between RC and hyperuricemia. This cross-sectional
study included 14 568 adults aged 20 years or older from the National Health and
Nutrition Examination Survey (NHANES) conducted between 2007 and 2018 in the
United States. RC is calculated by subtracting high-density lipoprotein
cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) from total
cholesterol (TC). Hyperuricemia is defined by serum uric acid (SUA)
levels≥7 mg/dl in men and≥6 mg/dl in women. The independent association between
RC and hyperuricemia was evaluated. As the quartile range of RC levels
increases, the prevalence of hyperuricemia also rises (7.84% vs. 13.71% vs.
18.61% vs. 26.24%, p<0.001). After adjusting for confounding factors, the
fourth quartile of RC was associated with an increased risk of hyperuricemia
compared with the first quartile (OR=2.942, 95% CI 2.473–3.502, p<0.001).
Receiver Operating Characteristic (ROC) analysis shows that RC outperforms other
single lipid indices in hyperuricemia. Further Restricted Cubic Splines (RCS)
analysis suggests a nonlinear relationship between RC levels and hyperuricemia.
Elevated RC levels were found to be linked to hyperuricemia. Further studies on
RC hold promise for both preventing and addressing hyperuricemia.
Keywords
remnant cholesterol -
hyperuricemia -
NHANES -
population-based study -
nonlinear relationship
Publication History
Received: 06 March 2024
Accepted after revision: 03 April 2024
Accepted Manuscript online:
03 April 2024
Article published online:
02 May 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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