Bjorkegren, J. L. M. & Lusis, A. J. Atherosclerosis: recent developments. Cell 185, 1630–1645 (2022).
Article CAS PubMed PubMed Central Google Scholar
van der Vorst, E. P. C. et al. G-protein coupled receptor targeting on myeloid cells in atherosclerosis. Front. Pharmacol. 10, 531 (2019).
Article PubMed PubMed Central Google Scholar
Yan, Y., Thakur, M., van der Vorst, E. P. C., Weber, C. & Doring, Y. Targeting the chemokine network in atherosclerosis. Atherosclerosis 330, 95–106 (2021).
Article CAS PubMed Google Scholar
Weber, C. & Noels, H. Atherosclerosis: current pathogenesis and therapeutic options. Nat. Med. 17, 1410–1422 (2011).
Article CAS PubMed Google Scholar
Soehnlein, O. & Libby, P. Targeting inflammation in atherosclerosis — from experimental insights to the clinic. Nat. Rev. Drug Discov. 20, 589–610 (2021).
Article CAS PubMed PubMed Central Google Scholar
Gencer, S., Evans, B. R., van der Vorst, E. P. C., Doring, Y. & Weber, C. Inflammatory chemokines in atherosclerosis. Cells 10, 226 (2021).
Article CAS PubMed PubMed Central Google Scholar
Lutgens, E. et al. Immunotherapy for cardiovascular disease. Eur. Heart J. 40, 3937–3946 (2019).
Article CAS PubMed Google Scholar
Hughes, C. E. & Nibbs, R. J. B. A guide to chemokines and their receptors. FEBS J. 285, 2944–2971 (2018).
Article CAS PubMed PubMed Central Google Scholar
Noels, H., Weber, C. & Koenen, R. R. Chemokines as therapeutic targets in cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 39, 583–592 (2019).
Article CAS PubMed Google Scholar
Blanchet, X., Weber, C. & von Hundelshausen, P. Chemokine heteromers and their impact on cellular function-a conceptual framework. Int. J. Mol. Sci. 24, 10925 (2023).
Article CAS PubMed PubMed Central Google Scholar
Gencer, S. et al. Atypical chemokine receptors in cardiovascular disease. Thromb. Haemost. 119, 534–541 (2019).
Doran, A. C. Inflammation resolution: implications for atherosclerosis. Circ. Res. 130, 130–148 (2022).
Article CAS PubMed PubMed Central Google Scholar
Back, M., Yurdagul, A. Jr., Tabas, I., Oorni, K. & Kovanen, P. T. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat. Rev. Cardiol. 16, 389–406 (2019).
PubMed PubMed Central Google Scholar
Basil, M. C. & Levy, B. D. Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat. Rev. Immunol. 16, 51–67 (2016).
Article CAS PubMed Google Scholar
Serhan, C. N. & Levy, B. D. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. J. Clin. Invest. 128, 2657–2669 (2018).
Article PubMed PubMed Central Google Scholar
Norling, L. V., Dalli, J., Flower, R. J., Serhan, C. N. & Perretti, M. Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler. Thromb. Vasc. Biol. 32, 1970–1978 (2012).
Article CAS PubMed PubMed Central Google Scholar
Sansbury, B. E. & Spite, M. Resolution of acute inflammation and the role of resolvins in immunity, thrombosis, and vascular biology. Circ. Res. 119, 113–130 (2016).
Article CAS PubMed PubMed Central Google Scholar
Maganto-Garcia, E. et al. Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment. J. Immunol. 187, 3521–3529 (2011).
Article CAS PubMed Google Scholar
Akkaya, B. et al. Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells. Nat. Immunol. 20, 218–231 (2019).
Article CAS PubMed PubMed Central Google Scholar
Subramanian, M., Thorp, E., Hansson, G. K. & Tabas, I. Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. J. Clin. Invest. 123, 179–188 (2013).
Article CAS PubMed Google Scholar
Ring, S., Schafer, S. C., Mahnke, K., Lehr, H. A. & Enk, A. H. CD4+ CD25+ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue. Eur. J. Immunol. 36, 2981–2992 (2006).
Article CAS PubMed Google Scholar
Pinderski Oslund, L. J. et al. Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 19, 2847–2853 (1999).
Article CAS PubMed Google Scholar
Raffin, C., Vo, L. T. & Bluestone, J. A. Treg cell-based therapies: challenges and perspectives. Nat. Rev. Immunol. 20, 158–172 (2020).
Article CAS PubMed Google Scholar
Saraiva, M., Vieira, P. & O’Garra, A. Biology and therapeutic potential of interleukin-10. J. Exp. Med. 217, e20190418 (2020).
Zhang, H. et al. Role of the CCL2-CCR2 axis in cardiovascular disease: pathogenesis and clinical implications. Front. Immunol. 13, 975367 (2022).
Article CAS PubMed PubMed Central Google Scholar
Bot, I. et al. A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy. Sci. Rep. 7, 52 (2017).
Article PubMed PubMed Central Google Scholar
Zivkovic, L., Asare, Y., Bernhagen, J., Dichgans, M. & Georgakis, M. K. Pharmacological targeting of the CCL2/CCR2 axis for atheroprotection: a meta-analysis of preclinical studies. Arterioscler. Thromb. Vasc. Biol. 42, e131–e144 (2022).
Article CAS PubMed Google Scholar
Georgakis, M. K. et al. Carriers of rare damaging CCR2 genetic variants are at lower risk of atherosclerotic disease. Preprint at medRxiv https://doi.org/10.1101/2023.08.14.23294063 (2023).
Article PubMed PubMed Central Google Scholar
Gilbert, J. et al. Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region. Am. J. Cardiol. 107, 906–911 (2011).
Article CAS PubMed Google Scholar
Lim, S. Y., Yuzhalin, A. E., Gordon-Weeks, A. N. & Muschel, R. J. Targeting the CCL2-CCR2 signaling axis in cancer metastasis. Oncotarget 7, 28697–28710 (2016).
Article PubMed PubMed Central Google Scholar
Obmolova, G. et al. Structural basis for high selectivity of anti-CCL2 neutralizing antibody CNTO 888. Mol. Immunol. 51, 227–233 (2012).
Article CAS PubMed Google Scholar
Kirk, P. S. et al. Inhibition of CCL2 signaling in combination with docetaxel treatment has profound inhibitory effects on prostate cancer growth in bone. Int. J. Mol. Sci. 14, 10483–10496 (2013).
Article PubMed PubMed Central Google Scholar
Loberg, R. D. et al. Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo. Cancer Res. 67, 9417–9424 (2007).
Article CAS PubMed Google Scholar
Pienta, K. J. et al. Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer. Invest. New Drugs 31, 760–768 (2013).
Article CAS PubMed Google Scholar
Pekayvaz, K. et al. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation. Immunity 56, 2325–2341.e15 (2023).
Article CAS PubMed PubMed Central Google Scholar
Cipriani, S. et al. Efficacy of the CCR5 antagonist maraviroc in reducing early, ritonavir-induced atherogenesis and advanced plaque progression in mice. Circulation 127, 2114–2124 (2013).
Article CAS PubMed Google Scholar
Francisci, D. et al. Maraviroc intensification modulates atherosclerotic progression in HIV-suppressed patients at high cardiova
留言 (0)