Hajdu SI. A note from history: landmarks in history of cancer, part 1. Cancer. 2011;117(5):1097–102.

Article  PubMed  Google Scholar 

DeVita VT Jr., Chu E. A history of cancer chemotherapy. Cancer Res. 2008;68(21):8643–53.

Article  CAS  PubMed  Google Scholar 

Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant Antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971;93(9):2325–7.

Article  CAS  PubMed  Google Scholar 

Schirrmacher V. From chemotherapy to biological therapy: a review of novel concepts to reduce the side effects of systemic cancer treatment (review). Int J Oncol. 2019;54(2):407–19.

Article  CAS  PubMed  Google Scholar 

Azim HA Jr., de Azambuja E, Colozza M, Bines J, Piccart MJ. Long-term toxic effects of adjuvant chemotherapy in breast cancer. Ann Oncol. 2011;22(9):1939–47.

Article  PubMed  Google Scholar 

Rattanakrong N, Siriphorn A, Boonyong S. Incidence density and factors associated with peripheral neuropathy among women with breast cancer during taxane-based chemotherapy. Sci Rep. 2022;12(1):10632.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manjunath M, Choudhary B. Triple-negative breast cancer: a run-through of features, classification and current therapies. Oncol Lett. 2021;22(1):512.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Howlader N, Cronin KA, Kurian AW, Andridge R. Differences in breast Cancer survival by Molecular subtypes in the United States. Cancer Epidemiol Biomarkers Prev. 2018;27(6):619–26.

Article  CAS  PubMed  Google Scholar 

Debien V, De Caluwe A, Wang X, Piccart-Gebhart M, Tuohy VK, Romano E, et al. Immunotherapy in breast cancer: an overview of current strategies and perspectives. NPJ Breast Cancer. 2023;9(1):7.

Article  PubMed  PubMed Central  Google Scholar 

Loizides S, Constantinidou A. Triple negative breast cancer: immunogenicity, tumor microenvironment, and immunotherapy. Front Genet. 2022;13:1095839.

Article  CAS  PubMed  Google Scholar 

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315–7.

Article  CAS  PubMed  Google Scholar 

Fernandez-Francos S, Eiro N, Costa LA, Escudero-Cernuda S, Fernandez-Sanchez ML, Vizoso FJ. Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine. Int J Mol Sci. 2021;22(7).

Eiro N, Fraile M, Fernandez-Francos S, Sanchez R, Costa LA, Vizoso FJ. Importance of the origin of mesenchymal (stem) stromal cells in cancer biology: alliance or war in intercellular signals. Cell Biosci. 2021;11(1):109.

Article  PubMed  PubMed Central  Google Scholar 

Wu Y, Shum HCE, Wu K, Vadgama J. From Interaction to intervention: how mesenchymal stem cells affect and target triple-negative breast Cancer. Biomedicines. 2023;11(4).

Eiro N, Sendon-Lago J, Seoane S, Bermudez MA, Lamelas ML, Garcia-Caballero T, et al. Potential therapeutic effect of the secretome from human uterine cervical stem cells against both cancer and stromal cells compared with adipose tissue stem cells. Oncotarget. 2014;5(21):10692–708.

Article  PubMed  PubMed Central  Google Scholar 

Schneider J, Eiro N, Perez-Fernandez R, Martinez-Ordonez A, Vizoso F. Human uterine cervical stromal stem cells (hUCESCs): why and how they exert their Antitumor activity. Cancer Genomics Proteom. 2016;13(5):331–7.

CAS  Google Scholar 

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007;449(7162):557–63.

Article  CAS  PubMed  Google Scholar 

Muehlberg FL, Song YH, Krohn A, Pinilla SP, Droll LH, Leng X, et al. Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis. 2009;30(4):589–97.

Article  CAS  PubMed  Google Scholar 

Galie M, Konstantinidou G, Peroni D, Scambi I, Marchini C, Lisi V, et al. Mesenchymal stem cells share molecular signature with mesenchymal tumor cells and favor early tumor growth in syngeneic mice. Oncogene. 2008;27(18):2542–51.

Article  CAS  PubMed  Google Scholar 

Eiro N, Gonzalez L, Martinez-Ordonez A, Fernandez-Garcia B, Gonzalez LO, Cid S, et al. Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis. Cell Oncol (Dordr). 2018;41(4):369–78.

Article  CAS  PubMed  Google Scholar 

Eiro N, Cid S, Aguado N, Fraile M, de Pablo N, Fernandez B et al. MMP1 and MMP11 expression in Peripheral Blood mononuclear cells upon their Interaction with breast Cancer cells and fibroblasts. Int J Mol Sci. 2020;22(1).

Melzer C, Rehn V, Yang Y, Bahre H, von der Ohe J, Hass R. Taxol-loaded MSC-Derived exosomes provide a therapeutic vehicle to target metastatic breast Cancer and other Carcinoma cells. Cancers (Basel). 2019;11(6).

Sendon-Lago J, Seoane S, Martinez-Ordonez A, Eiro N, Saa J, Vizoso FJ, et al. Corneal regeneration by conditioned medium of human uterine cervical stem cells is mediated by TIMP-1 and TIMP-2. Exp Eye Res. 2019;180:110–21.

Article  CAS  PubMed  Google Scholar 

Li P, Kaslan M, Lee SH, Yao J, Gao Z. Progress Exosome Isolation Techniques Theranostics. 2017;7(3):789–804.

CAS  PubMed  Google Scholar 

Vizoso FJ, Eiro N, Cid S, Schneider J, Perez-Fernandez R. Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in Regenerative Medicine. Int J Mol Sci. 2017;18(9).

Kim MS, Haney MJ, Zhao Y, Mahajan V, Deygen I, Klyachko NL, et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine. 2016;12(3):655–64.

Article  CAS  PubMed  Google Scholar 

Salarpour S, Forootanfar H, Pournamdari M, Ahmadi-Zeidabadi M, Esmaeeli M, Pardakhty A. Paclitaxel incorporated exosomes derived from glioblastoma cells: comparative study of two loading techniques. Daru. 2019;27(2):533–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rhee KJ, Lee JI, Eom YW. Mesenchymal stem cell-mediated effects of Tumor support or suppression. Int J Mol Sci. 2015;16(12):30015–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hmadcha A, Martin-Montalvo A, Gauthier BR, Soria B, Capilla-Gonzalez V. Therapeutic potential of mesenchymal stem cells for Cancer Therapy. Front Bioeng Biotechnol. 2020;8:43.

Article  PubMed  PubMed Central  Google Scholar 

Heidari R, Gholamian Dehkordi N, Mohseni R, Safaei M. Engineering mesenchymal stem cells: a novel therapeutic approach in breast cancer. J Drug Target. 2020;28(7–8):732–41.

Article  CAS  PubMed  Google Scholar 

Costa LA, Eiro N, Fraile M, Gonzalez LO, Saa J, Garcia-Portabella P, et al. Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses. Cell Mol Life Sci. 2021;78(2):447–67.

Article  CAS  PubMed  Google Scholar 

Sendon-Lago J, Seoane S, Saleh F, Garcia-Caballero L, Arias ME, Eiro N, et al. In vivo effects of conditioned medium from human uterine cervical stem cells in an ovarian Cancer Xenograft Mouse Model. Cancer Genomics Proteom. 2022;19(5):570–5.

Article  CAS  Google Scholar 

Nadesh R, Menon KN, Biswas L, Mony U, Subramania Iyer K, Vijayaraghavan S, et al. Adipose derived mesenchymal stem cell secretome formulation as a biotherapeutic to inhibit growth of drug resistant triple negative breast cancer. Sci Rep. 2021;11(1):23435.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Serras AS, Camões SP, Antunes B, Costa VM, Dionísio F, Yazar V et al. The Secretome of Human neonatal mesenchymal stem cells modulates Doxorubicin-Induced cytotoxicity: impact in Non-tumor cells. Int J Mol Sci. 2021;22(23).

Sousa A, Coelho P, Leite F, Teixeira C, Rocha AC, Santos I et al. Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood serum in prostate cancer progression. Hum Cell. 2023.

Han KH, Kim AK, Jeong GJ, Jeon HR, Bhang SH, Kim DI. Enhanced Anti-cancer effects of Conditioned Medium from Hypoxic Human umbilical cord-derived mesenchymal stem cells. Int J Stem Cells. 2019;12(2):291–303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Miranda MC, Ferreira ADF, de Melo MIA, Kunrath-Lima M, Goes AM, Rodrigues MA, et al. Adipose-derived stem/stromal cell secretome modulates breast cancer cell proliferation and differentiation state towards aggressiveness. Biochimie. 2021;191:69–77.

Article  PubMed  Google Scholar 

Serras AS, Camoes SP, Antunes B, Costa VM, Dionisio F, Yazar V et al. The Secretome of Human neonatal mesenchymal stem cells modulates Doxorubicin-Induced cytotoxicity: impact in Non-tumor cells. Int J Mol Sci. 2021;22(23).

Bosco DB, Kenworthy R, Zorio DA, Sang QX. Human mesenchymal stem cells are resistant to Paclitaxel by adopting a non-proliferative fibroblastic state. PLoS ONE. 2015;10(6):e0128511.

Article  PubMed  PubMed Central  Google Scholar 

Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, et al. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell Vesicles. 2019;8(1):1609206.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kou M, Huang L, Yang J, Chiang Z, Chen S, Liu J, et al. Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? Cell Death Dis. 2022;13(7):580.

Article  CAS  PubMed