These authors contributed equally: Liang Chen, Mengjia Hong, Changming Luan.

Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China

Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Dujuan Zhang, Shun Zhang, Jun Wu, Chao Qu, Yifan Zhu, Yuting Guan, Liren Wang, Mingyao Liu, Gaojie Song & Dali Li

Department of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Changwei Li

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA

Peyton B. Randolph, Alexander A. Sousa & David R. Liu

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA

Peyton B. Randolph, Alexander A. Sousa & David R. Liu

Howard Hughes Medical Institute, Cambridge, MA, USA

Peyton B. Randolph, Alexander A. Sousa & David R. Liu

BRL Medicine, Inc., Shanghai, China

Mingyao Liu

School of Biomedical Sciences, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China

Bo Feng