Moss BJ, Ryter SW, Rosas IO. Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu Rev Pathol Mech Dis. 2021;17:515–46.

Article  Google Scholar 

Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, Behr J, Cottin V, Danoff SK, Morell F, et al. Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Am J Respir Crit Care Med. 2018;198:e44–68.

Article  PubMed  Google Scholar 

Herzog EL, Mathur A, Tager AM, Feghali-Bostwick C, Schneider F, Varga J. Review: interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct? Arthritis Rheumatol (Hoboken, NJ). 2014;66:1967–78.

Article  CAS  Google Scholar 

Hambly N, Farooqi MM, Dvorkin-Gheva A, Donohoe K, Garlick K, Scallan C, Chong SG, MacIsaac S, Assayag D, Johannson KA, et al. Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry. Eur Respir J. 2022;60:2102571.

Article  PubMed  Google Scholar 

D’Agnano V, Mariniello DF, Ruotolo M, Quarcio G, Moriello A, Conte S, Sorrentino A, Sanduzzi Zamparelli S, Bianco A, Perrotta F. Targeting progression in pulmonary fibrosis: an overview of underlying mechanisms, molecular biomarkers, and therapeutic intervention. Life. 2024;14:229.

Article  PubMed  PubMed Central  Google Scholar 

Rubio-Rivas M, Royo C, Simeón CP, Corbella X, Fonollosa V. Mortality and survival in systemic sclerosis: systematic review and meta-analysis. Semin Arthritis Rheum. 2014;44:208–19.

Article  PubMed  Google Scholar 

Luckhardt TR, Thannickal VJ. Systemic sclerosis-associated fibrosis: an accelerated aging phenotype? Curr Opin Rheumatol. 2015;27:571–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Todd NW, Luzina IG, Atamas SP. Molecular and cellular mechanisms of pulmonary fibrosis. Fibrogen Tissue Repair. 2012;5:11.

Article  CAS  Google Scholar 

van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509:439–46.

Article  PubMed  PubMed Central  Google Scholar 

Parimon T, Yao C, Stripp BR, Noble PW, Chen P. Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis. Int J Mol Sci. 2020;21:2269.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazumder S, Barman M, Bandyopadhyay U, Bindu S. Sirtuins as endogenous regulators of lung fibrosis: a current perspective. Life Sci. 2020;258: 118201.

Article  CAS  PubMed  Google Scholar 

Perrotta F, Chino V, Allocca V, D’Agnano V, Bortolotto C, Bianco A, Corsico AG, Stella GM. Idiopathic pulmonary fibrosis and lung cancer: targeting the complexity of the pharmacological interconnection. Expert Rev Respir Med. 2022;16:1043–55.

Article  CAS  PubMed  Google Scholar 

Stella GM, D’Agnano V, Piloni D, Saracino L, Lettieri S, Mariani F, Lancia A, Bortolotto C, Rinaldi P, Falanga F, et al. The oncogenic landscape of the idiopathic pulmonary fibrosis: a narrative review. Transl Lung Cancer Res. 2022;11:472–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji Z, Liu G-H, Qu J. Mitochondrial sirtuins, metabolism, and aging. J Genet Genom. 2022;49:287–98.

Article  CAS  Google Scholar 

Aventaggiato M, Barreca F, Sansone L, Pellegrini L, Russo MA, Cordani M, Tafani M. Sirtuins and hypoxia in EMT control. Pharmaceuticals (Basel). 2022;15:737.

Article  CAS  PubMed  Google Scholar 

Corbi G, Bianco A, Turchiarelli V, Cellurale M, Fatica F, Daniele A, Mazzarella G, Ferrara N. Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on Sirtuins. Int J Mol Sci. 2013;14:12696–713.

Article  PubMed  PubMed Central  Google Scholar 

Michan S, Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem J. 2007;404:1–13.

Article  CAS  PubMed  Google Scholar 

Zhang N, Li Z, Mu W, Li L, Liang Y, Lu M, Wang Z, Qiu Y, Wang Z. Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling. Cell Cycle. 2016;15:1009–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, et al. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science. 2011;334:806–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scher MB, Vaquero A, Reinberg D. SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev. 2007;21:920–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bindu S, Pillai VB, Gupta MP. Role of sirtuins in regulating pathophysiology of the heart. Trends Endocrinol Metab. 2016;27:563–73.

Article  CAS  PubMed  Google Scholar 

Herskovits AZ, Guarente L. Sirtuin deacetylases in neurodegenerative diseases of aging. Cell Res. 2013;23:746–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoue T, Hiratsuka M, Osaki M, Yamada H, Kishimoto I, Yamaguchi S, Nakano S, Katoh M, Ito H, Oshimura M. SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress. Oncogene. 2007;26:945–57.

Article  CAS  PubMed  Google Scholar 

Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005;16:4623–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Königshoff M, Balsara N, Pfaff E-M, Kramer M, Chrobak I, Seeger W, Eickelberg O. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS ONE. 2008;3: e2142.

Article  PubMed  PubMed Central  Google Scholar 

Tian Y, Li H, Qiu T, Dai J, Zhang Y, Chen J, Cai H. Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-κB activation. Aging Cell. 2019;18: e12858.

Article  PubMed  Google Scholar 

Kawahara TLA, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KCL, Boxer LD, Chang HY, et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell. 2009;136:62–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian K, Chen P, Liu Z, Si S, Zhang Q, Mou Y, Han L, Wang Q, Zhou X. Sirtuin 6 inhibits epithelial to mesenchymal transition during idiopathic pulmonary fibrosis via inactivating TGF-β1/Smad3 signaling. Oncotarget. 2017;8:61011–24.

Article  PubMed  PubMed Central  Google Scholar 

Wang F, Marshall CB, Ikura M. Forkhead followed by disordered tail: the intrinsically disordered regions of FOXO3a. Intrinsical Disord Proteins. 2015;3: e1056906.

Article  Google Scholar 

Giannakou ME, Partridge L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol. 2004;14:408–12.

Article  CAS  PubMed  Google Scholar 

Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 2001;107:137–48.

Article  CAS  PubMed  Google Scholar 

Sehgal M, Jakhete SM, Manekar AG, Sasikumar S. Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis. Heliyon. 2022;8: e09773.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ming Y, Yin Y, Sun Z. Interaction of nuclear receptor subfamily 4 group a member 1 (Nr4a1) and liver linase B1 (LKB1) mitigates type 2 diabetes mellitus by activating monophosphate-activated protein kinase (AMPK)/Sirtuin 1 (SIRT1) axis and inhibiting nuclear factor-kappa B. Med Sci Monit Int Med J Exp Clin Res. 2020;26: e920278.

CAS  Google Scholar 

Deskata K, Malli F, Jagirdar R, Vavougios GD, Zarogiannis S, Gourgoulianis KI, Daniil Z. Evaluation of Sirtuin 1 levels in peripheral blood mononuclear cells of patients with idiopathic pulmonary fibrosis. Cureus. 2022;14: e30862.

PubMed  PubMed Central  Google Scholar 

Zeng Z, Cheng S, Chen H, Li Q, Hu Y, Wang Q, Zhu X, Wang J. Activation and overexpression of Sirt1 attenuates lung fibrosis via P300. Biochem Biophys Res Commun. 2017;486:1021–6.

Article  CAS  PubMed  Google Scholar 

Han S, Lu Q, Liu X. Advances in cellular senescence in idiopathic pulmonary fibrosis (Review). Exp Ther Med. 2023;25:145.

Article  CAS  PubMed  PubMed Central  Google Scholar