Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418:935–41.

Article  CAS  PubMed  Google Scholar 

Takahashi JS. Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet. 2016;18:164–79.

Article  PubMed  PubMed Central  Google Scholar 

Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006;15:R271–7.

Article  CAS  PubMed  Google Scholar 

Easton A, Arbuzova J, Turek FW. The circadian Clock mutation increases exploratory activity and escape-seeking behavior. Genes Brain Behav. 2003;2:11–9.

Article  CAS  PubMed  Google Scholar 

Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, et al. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA. 2007;104:6406–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benedetti F, Serretti A, Colombo C, Barbini B, Lorenzi C, Campori E, et al. Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression. Am J Med Genet B Neuropsychiatr Genet. 2003;123B:23–6.

Article  PubMed  Google Scholar 

Benedetti F, Dallaspezia S, Colombo C, Pirovano A, Marino E, Smeraldi E. A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neurosci Lett. 2008;445:184–7.

Article  CAS  PubMed  Google Scholar 

Johansson C, Willeit M, Smedh C, Ekholm J, Paunio T, Kieseppä T, et al. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology. 2003;28:734–9.

Article  CAS  PubMed  Google Scholar 

Lavebratt C, Sjöholm LK, Soronen P, Paunio T, Vawter MP, Bunney WE, et al. CRY2 is associated with depression. PLoS ONE. 2010;5:e9407.

Mansour HA, Talkowski ME, Wood J, Chowdari KV, McClain L, Prasad K, et al. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009;11:701–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bi J, Gelernter J, Sun J, Kranzler HR. Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis. Am J Med Genet Part B Neuropsychiatr Genet. 2014;165:148–56.

Article  CAS  Google Scholar 

Baranger DAA, Ifrah C, Prather AA, Carey CE, Corral-Frías NS, Drabant Conley E, et al. PER1 rs3027172 genotype interacts with early life stress to predict problematic alcohol use, but not reward-related ventral striatum activity. Front Psychol. 2016;7:464.

Article  PubMed  PubMed Central  Google Scholar 

Blomeyer D, Buchmann AF, Lascorz J, Zimmermann US, Esser G, Desrivieres S, et al. Association of PER2 genotype and stressful life events with alcohol drinking in young adults. PLoS ONE. 2013;8:e59136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forbes EE, Dahl RE, Almeida JRC, Ferrell RE, Nimgaonkar VL, Mansour H, et al. PER2 rs2304672 polymorphism moderates circadian-relevant reward circuitry activity in adolescents. Biol Psychiatry. 2012;71:451–7.

Article  CAS  PubMed  Google Scholar 

Gamsby JJ, Templeton EL, Bonvini LA, Wang W, Loros JJ, Dunlap JC, et al. The circadian Per1 and Per2 genes influence alcohol intake, reinforcement, and blood alcohol levels. Behav Brain Res. 2013;249:15–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozburn AR, Larson EB, Self DW, McClung CA. Cocaine self-administration behaviors in ClockΔ19 mice. Psychopharmacology 2012;223:169–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ozburn AR, Falcon E, Mukherjee S, Gillman A, Arey R, Spencer S, et al. The Role of Clock in Ethanol-Related Behaviors. Neuropsychopharmacology. 2013;38:2393–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong L, Bilbao A, Laucht M, Henriksson R, Yakovleva T, Ridinger M, et al. Effects of the circadian rhythm gene period 1 (Per1) on psychosocial stress-induced alcohol drinking. Am J Psychiatry. 2011;168:1090–8.

Article  PubMed  Google Scholar 

Wise RA, Rompre PP. Brain dopamine and reward. Annu Rev Psychol. 1989;40:191–225.

Article  CAS  PubMed  Google Scholar 

DePoy LM, McClung CA, Logan RW. Neural mechanisms of circadian regulation of natural and drug reward. Neural Plast. 2017;2017:1–14.

Article  Google Scholar 

Parekh PK, Becker-Krail D, Sundaravelu P, Ishigaki S, Okado H, Sobue G, et al. Altered GluA1 (Gria1) function and accumbal synaptic plasticity in the ClockΔ19 model of bipolar mania. Biol Psychiatry. 2018;84:817–26.

Article  CAS  PubMed  Google Scholar 

DePoy LM, Becker-Krail DD, Zong W, Petersen K, Shah NM, Brandon JH, et al. Circadian-dependent and sex-dependent increases in intravenous cocaine self-administration in Npas2 mutant mice. J Neurosci. 2021;41:1046.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parekh PK, Logan RW, Ketchesin KD, Becker-Krail D, Shelton MA, Hildebrand MA, et al. Cell-type specific regulation of nucleus accumbens synaptic plasticity and cocaine reward sensitivity by the circadian protein, NPAS2. J Neurosci. 2019;39:4657–67.

Lobo MK, Covington HE, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, et al. Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science. 2010;330:385–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen S, Ma D, Zhao M, Xie L, Wu Q, Gou L, et al. Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus. Nat Neurosci. 2020;23:456–67.

Article  CAS  PubMed  Google Scholar 

Brami-Cherrier K, Lewis RG, Cervantes M, Liu Y, Tognini P, Baldi P, et al. Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation. Nat Commun. 2020;11:4448.

Ketchesin KD, Zong W, Hildebrand MA, Seney ML, Cahill KM, Scott MR, et al. Diurnal rhythms across the human dorsal and ventral striatum. Proc Natl Acad Sci USA. 2021;118:2016150118.

Article  Google Scholar 

Becker-Krail DD, Ketchesin KD, Burns JN, Zong W, Hildebrand MA, DePoy LM, et al. Astrocyte molecular clock function in the nucleus accumbens is important for reward-related behavior. Biol Psychiatry. 2022;92:68–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatcher KM, Royston SE, Mahoney MM. Modulation of circadian rhythms through estrogen receptor signaling. Eur J Neurosci. 2018;51:217–28.

Becker JB, Hu M. Sex differences in drug abuse. Front Neuroendocrinol. 2008;29:36–47.

Article  CAS  PubMed  Google Scholar 

Chandra R, Francis TC, Konkalmatt P, Amgalan A, Gancarz AM, Dietz DM, et al. Opposing Role for Egr3 in nucleus accumbens cell subtypes in cocaine action. J Neurosci. 2015;35:7927.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cornelissen G. Cosinor-based rhythmometry. Theor Biol Med Model. 2014;11:16.

Article  PubMed  PubMed Central  Google Scholar 

Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:1–21.

Article  Google Scholar 

Cahill KM, Huo Z, Tseng GC, Logan RW, Seney ML. Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach. Sci Rep. 2018;8:1–11.

Article  CAS  Google Scholar 

Tran MN, Maynard KR, Spangler A, Huuki LA, Montgomery KD, Sadashivaiah V, et al. Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain. Neuron. 2021;109:3088–3103.e5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kosten TA, Gawin FH, Kosten TR, Rounsaville BJ. Gender differences in cocaine use and treatment response. J Subst Abuse Treat. 1993;10:63–6.

Article  CAS  PubMed  Google Scholar 

Kennedy AP, Epstein DH, Phillips KA, Preston KL. Sex differences in cocaine/heroin users: drug-use triggers and craving in daily life. Drug Alcohol Depend. 2013;132:29–37.

Article  PubMed  PubMed Central  Google Scholar 

Robbins SJ, Ehrman RN, Childress AR, O’Brien CP. Comparing levels of cocaine cue reactivity in male and female outpatients. Drug Alcohol Depend. 1999;53:223–30.

Article  CAS  PubMed  Google Scholar 

Mavroudis PD, DuBois DC, Almon RR, Jusko WJ. Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat. PLoS ONE 2018;13:e0197534.

Article  PubMed  PubMed Central  Google Scholar 

Ozburn AR, Falcon E, Twaddle A, Nugent AL, Gillman AG, Spencer SM, et al. Direct regulation of diurnal drd3 expression and cocaine reward by npas2. Biol Psychiatry. 2015;77:425–33.