Agarwal S, Behring M, Hale K, Al Diffalha S, Wang K, Manne U (2019) MTHFD1L, A folate cycle enzyme, is involved in progression of colorectal cancer. Transl Oncol 12(11):1461–1467

Article  PubMed  PubMed Central  Google Scholar 

Anderson DD, Quintero CM, Stover PJ (2011) Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proc Natl Acad Sci U S A 108(37):15163–15168

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balogh KN, Templeton DJ, Cross JV (2018) Macrophage Migration Inhibitory Factor protects cancer cells from immunogenic cell death and impairs anti-tumor immune responses. PLoS ONE 13(6):e0197702

Article  PubMed  PubMed Central  Google Scholar 

Ben Fradj MK, Ouanes Y, Hadj-Taeib S, Mrad Dali K, Bibi M, Jmal K (2021) Prognostic significance of plasma folate and cobalamin concentrations in non-muscle-invasive bladder cancer: a prospective cohort study. Cancer Invest 39(3):240–250

Article  CAS  PubMed  Google Scholar 

Chen J, Na R, Xiao C, Wang X, Wang Y, Yan D (2021a) The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy. Oncogene 40(23):3974–3988

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Yang J, Xu Q, Wang Z, Wu J, Pan L (2021) Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma. Biosci Rep. https://doi.org/10.1042/BSR20202063

Cohen EE, LaMonte SJ, Erb NL, Beckman KL, Sadeghi N, Hutcheson KA (2016) American cancer society head and neck cancer survivorship care guideline. CA Cancer J Clin 66(3):203–239

Article  PubMed  Google Scholar 

Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297(21):2351–2359

Article  CAS  PubMed  Google Scholar 

DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D (2015) NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet 47(12):1475–1481

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding J, Li T, Wang X, Zhao E, Choi JH, Yang L (2013) The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation. Cell Metab 18(6):896–907

Article  CAS  PubMed  Google Scholar 

Ducker GS, Rabinowitz JD (2017) One-carbon metabolism in health and disease. Cell Metab 25(1):27–42

Article  CAS  PubMed  Google Scholar 

Ebbing M, Bonaa KH, Nygard O, Arnesen E, Ueland PM, Nordrehaug JE (2009) Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 302(19):2119–2126

Article  CAS  PubMed  Google Scholar 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359–E386

Article  CAS  PubMed  Google Scholar 

Figueiredo JC, Grau MV, Haile RW, Sandler RS, Summers RW, Bresalier RS (2009) Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 101(6):432–435

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gore Y, Starlets D, Maharshak N, Becker-Herman S, Kaneyuki U, Leng L (2008) Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J Biol Chem 283(5):2784–2792

Article  CAS  PubMed  Google Scholar 

He H, Shui B (2014) Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies. Int J Food Sci Nutr 65(3):286–292

Article  CAS  PubMed  Google Scholar 

Jiang L, Chen S, Pan Q, Zheng J, He J, Sun J (2022) The feasibility of proteomics sequencing based immune-related prognostic signature for predicting clinical outcomes of bladder cancer patients. BMC Cancer 22(1):676

Article  PubMed  PubMed Central  Google Scholar 

Jin Y, Jung SN, Lim MA, Oh C, Piao Y, Kim HJ (2022) SHMT2 induces stemness and progression of head and neck cancer. Int J Mol Sci 23(17):9714

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR (2020) Head and neck squamous cell carcinoma. Nat Rev Dis Primers 6(1):92

Article  PubMed  PubMed Central  Google Scholar 

Kim YI (2007) Folate and colorectal cancer: an evidence-based critical review. Mol Nutr Food Res 51(3):267–292

Article  CAS  PubMed  Google Scholar 

Kim SE (2020) Enzymes involved in folate metabolism and its implication for cancer treatment. Nutr Res Pract 14(2):95–101

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klemke L, De Oliveira T, Witt D, Winkler N, Bohnenberger H, Bucala R (2021) Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer. Cell Death Dis 12(2):155

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee GY, Haverty PM, Li L, Kljavin NM, Bourgon R, Lee J (2014) Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes. Cancer Res 74(11):3114–3126

Article  CAS  PubMed  Google Scholar 

Li L, Zhang Y, Hu W, Zou F, Ning J, Rao T (2023) MTHFD2 promotes PD-L1 expression via activation of the JAK/STAT signalling pathway in bladder cancer. J Cell Mol Med 27(19):2922–2936

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paijens ST, Vledder A, de Bruyn M, Nijman HW (2021) Tumor-infiltrating lymphocytes in the immunotherapy era. Cell Mol Immunol 18(4):842–859

Article  CAS  PubMed  Google Scholar 

Pantouris G, Ho J, Shah D, Syed MA, Leng L, Bhandari V (2018) Nanosecond dynamics regulate the MIF-induced activity of CD74. Angew Chem Int Ed Engl 57(24):7116–7119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J (2020) The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nat Cancer 1:653–664

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajasekaran D, Groning S, Schmitz C, Zierow S, Drucker N, Bakou M (2016) Macrophage migration inhibitory factor-CXCR4 receptor interactions: evidence for partial allosteric agonism in comparison with CXCL12 CHEMOKINE. J Biol Chem 291(30):15881–15895

Article  CAS  PubMed  PubMed Central  Google Scholar 

Samaniego R, Palacios BS, Domiguez-Soto A, Vidal C, Salas A, Matsuyama T (2014) Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A. J Leukoc Biol 95(5):797–808

Article  PubMed  Google Scholar 

Shang M, Yang H, Yang R, Chen T, Fu Y, Li Y (2021) The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation. Nat Commun 12(1):1940

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sierra-Filardi E, Puig-Kroger A, Blanco FJ, Nieto C, Bragado R, Palomero MI (2011) Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood 117(19):5092–5101

Article  CAS  PubMed  Google Scholar 

Stolzenberg-Solomon RZ, Chang SC, Leitzmann MF, Johnson KA, Johnson C, Buys SS (2006) Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr 83(4):895–904

Article  CAS  PubMed  Google Scholar 

Sugiura A, Andrejeva G, Voss K, Heintzman DR, Xu X, Madden MZ (2022) MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity 55(1):65-81 e9

Article  CAS  PubMed  Google Scholar 

Tibbetts AS, Appling DR (2010) Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annu Rev Nutr 30:57–81

Article  CAS  PubMed  Google Scholar 

Wang H, Yang C, Li D, Wang R, Li Y, Lv L (2023) Bioinformatics analysis and experimental validation of a novel autophagy-related signature relevant to immune infiltration for recurrence prediction after curative hepatectomy. Aging (Albany NY) 15(7):2610–2630

Article  CAS  PubMed  Google Scholar 

Wu Y, Chen W, Xu ZP, Gu W (2019) PD-L1 distribution and perspective for cancer immunotherapy-blockade, knockdown, or inhibition. Front Immunol 10:2022