Conflict of interest

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Tamura and Fukuda have nothing to disclose. Dr. Okuma reports grants from Roche, grants from ABBVIE K.K, personal fees from AstraZeneca, personal fees from EIi-Lilly K.K, personal fees from Bristol Meiers Squibb, personal fees from Pfizer Taiho Pharma Co. Ltd., personal fees from AstraZeneca Nippon Boehringer Ingelheim, personal fees from Chugai Pharma Co. Ltd., personal fees from Ono Pharma Co. Ltd., personal fees from Taiho Pharma Co. Ltd., outside the submitted work. Dr. Nomura reports grants and personal fees from AstraZeneca, personal fees from Chugai, grants from Amgen, personal fees from KyowaHakko, personal fees from JMDC, grants from Byer, personal fees from Asahi-Kasei Pharma, outside the submitted work. Dr. Masuda reports personal fees from ONO, personal fees from AstraZeneca, personal fees from Chugai, personal fees from Bristol Myers Squibb, outside the submitted work. Dr. Matsumoto reports grants from National Cancer Center Research and Development Fund, grants from Grant-in-Aid for Scientific Research on Innovative Areas, grants from Hitachi, Ltd. Grants, personal fees from Olympus, personal fees from AstraZeneca, personal fees from Novartis, personal fees from COOK, personal fees from AMCO INC, personal fees from Thermo Fisher Scientific, personal fees from Erbe Elektromedizin GmbH, personal fees from Fujifilm, personal fees from Chugai, personal fees from Eli Lilly, outside the submitted work. Dr. Shinno reports personal fees from BMS, personal fees from Chugai, personal fees from Astra Zeneca, personal fees from Eli Lilly, grants and personal fees from Ono, grants from Janssen, grants from Japan Clinical Research Operations K.K., outside the submitted work. Dr. Yoshida reports grants and personal fees from AMGEN, grants and personal fees from Astrazeneca, grants from Takeda, grants from Daiichi Sankyo, grants and personal fees from Ono, grants and personal fees from MSD, grants from Abbvie, grants and personal fees from Novartis, grants and personal fees from Chugai, grants and personal fees from BMS, personal fees from TAIHO, personal fees from Lilly, personal fees from Roche, personal fees from ArcherDX, outside the submitted work. Dr. Goto reports grants from AZK, grants and personal fees from Pfizer, grants from Abbvie, grants and personal fees from Eli Lilly, grants and personal fees from Bristol Myers Squibb, grants and personal fees from Ono, grants and personal fees from Novartis, grants from Kyorin, grants and personal fees from DaiichiSankyo, grants from Prefered Network, personal fees from Chugai, personal fees from Taiho, personal fees from Boehringer Ingelheim, personal fees from MSD, personal fees from Merck, personal fees from Thermo Fischer, personal fees from AstraZeneca, personal fees from Chugai, personal fees from Guardant Health Inc., personal fees from Illumina, outside the submitted work. Dr. Horinouchi reports grants and personal fees from MSD, grants from Abbvie, grants and personal fees from AstraZeneca, grants and personal fees from BMS, grants and personal fees from Ono, grants from Merck Biophama, grants from Daiichi-Sankyo, grants from Janssen, grants from Genomic Helath, grants and personal fees from Chugai, grants and personal fees from Roche, grants and personal fees from Novartis, personal fees from Eli Lilly, personal fees from Kyowa-Kirin, outside the submitted work. Dr. Yamamoto reports grants and personal fees from Chugai, grants from Taiho, grants and personal fees from Eisai, grants and personal fees from Lilly, grants from Quintiles, grants from Astellas, grants and personal fees from BMS, grants from Novartis, grants from Daiichi-Sankyo, grants and personal fees from Pfizer, grants and personal fees from Boehringer Ingelheim, grants from Kyowa-Hakko Kirin, grants from Bayer, grants and personal fees from ONO PHARMACEUTICAL CO., LTD, grants and personal fees from Takeda, grants from Janssen Pharma, grants from MSD, grants from Merck, personal fees from Sysmex, grants from GSK, grants from Sumitomo Dainippon, grants from Chiome Bioscience Inc., grants and personal fees from Otsuka, grants from Carna Biosciences, grants from Genmab, grants from Shionogi, personal fees from AstraZeneca, personal fees from Cimic, outside the submitted work. Dr. Ohe reports grants and personal fees from AstraZeneca, grants and personal fees from Chugai, grants and personal fees from Eli Lilly, grants and personal fees from ONO, grants and personal fees from BMS, grants and personal fees from Kyorin, grants from Dainippon-Sumitomo, grants and personal fees from Pfizer, grants and personal fees from Taiho, grants from Novartis, grants from Takeda, grants from Kissei, grants from Daiichi-Sankyo, grants from Janssen, grants from LOXO, personal fees from Boehringer Ingelheim, personal fees from Bayer, personal fees from MSD, personal fees from Nippon Kayaku, personal fees from Kyowa Hakko Kirin, personal fees from Celltrion, personal fees from Amgen, personal fees from AnHeeart Tharapeutics Inc., outside the submitted work.

Consent to participate

The opportunity to refuse this study by subjects was guaranteed with details of this study available to the public.

Ethics approval

This study was approved by the Committee of the National Cancer Center Hospital (2015–355).