Sanchez DJ, Simon MC. Genetic and metabolic hallmarks of clear cell renal cell carcinoma. Biochim Biophys Acta Rev Cancer. 2018;1870(1):23–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hakimi AA, Pham CG, Hsieh JJ. A clear picture of renal cell carcinoma. Nat Genet. 2013;45(8):849–50.

Article  CAS  PubMed  Google Scholar 

Karakiewicz PI, Briganti A, Chun FK, Trinh QD, Perrotte P, Ficarra V, Cindolo L, De la Taille A, Tostain J, Mulders PF, et al. Multi-institutional validation of a new renal cancer-specific survival nomogram. J Clin Oncol. 2007;25(11):1316–22.

Article  PubMed  Google Scholar 

Ljungberg B, Albiges L, Abu-Ghanem Y, Bensalah K, Dabestani S, Fernandez-Pello S, Giles RH, Hofmann F, Hora M, Kuczyk MA, et al. European Association of Urology guidelines on renal cell carcinoma: the 2019 update. Eur Urol. 2019;75(5):799–810.

Article  PubMed  Google Scholar 

Wood CG. Multimodal approaches in the management of locally advanced and metastatic renal cell carcinoma: combining surgery and systemic therapies to improve patient outcome. Clin Cancer Res. 2007;13(2 Pt 2):697s–702s.

Article  PubMed  Google Scholar 

Kanao K, Mizuno R, Kikuchi E, Miyajima A, Nakagawa K, Ohigashi T, Nakashima J, Oya M. Preoperative prognostic nomogram (probability table) for renal cell carcinoma based on TNM classification. J Urol. 2009;181(2):480–5; discussion 485.

Article  PubMed  Google Scholar 

Rahimi A, Gonen M. Discriminating early- and late-stage cancers using multiple kernel learning on gene sets. Bioinformatics. 2018;34(13):i412–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rau A, Flister M, Rui H, Auer PL. Exploring drivers of gene expression in the Cancer Genome Atlas. Bioinformatics. 2019;35(1):62–8.

Article  CAS  PubMed  Google Scholar 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al. NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013;41(Database issue):D991-995.

CAS  PubMed  Google Scholar 

Mariani L, Miceli R, Kattan MW, Brennan MF, Colecchia M, Fiore M, Casali PG, Gronchi A. Validation and adaptation of a nomogram for predicting the survival of patients with extremity soft tissue sarcoma using a three-grade system. Cancer. 2005;103(2):402–8.

Article  PubMed  Google Scholar 

Kattan MW. Nomograms are superior to staging and risk grouping systems for identifying high-risk patients: preoperative application in prostate cancer. Curr Opin Urol. 2003;13(2):111–6.

Article  PubMed  Google Scholar 

Xia ZN, Wu JG, Yao WH, Meng YY, Jian WG, Wang TD, Xue W, Yu YP, Cai LC, Wang XY, et al. Identification of a differentiation-related prognostic nomogram based on single-cell RNA sequencing in clear cell renal cell carcinoma. Sci Rep. 2022;12(1):10973.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Luo Y, Wang G, Qian K, Qian G, Wu CL, Dan HC, Wang X, Xiao Y. Prognostic value of a gene signature in clear cell renal cell carcinoma. J Cell Physiol. 2019;234(7):10324–35.

Article  CAS  PubMed  Google Scholar 

Debs S, Ferreira CR, Groden C, Kim HJ, King KA, King MC, Lehky T, Cowen EW, Brown LH, Merideth M, et al. Adult diagnosis of congenital serine biosynthesis defect: a treatable cause of progressive neuropathy. Am J Med Genet A. 2021;185(7):2102–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shapira Zaltsberg G, McMillan HJ, Miller E. Phosphoserine aminotransferase deficiency: imaging findings in a child with congenital microcephaly. J Matern Fetal Neonatal Med. 2020;33(6):1033–5.

Article  CAS  PubMed  Google Scholar 

Jin HO, Hong SE, Kim JY, Jang SK, Kim YS, Sim JH, Oh AC, Kim H, Hong YJ, Lee JK, et al. Knock-down of PSAT1 enhances sensitivity of NSCLC cells to glutamine-limiting conditions. Anticancer Res. 2019;39(12):6723–30.

Article  CAS  PubMed  Google Scholar 

Liu B, Jia Y, Cao Y, Wu S, Jiang H, Sun X, Ma J, Yin X, Mao A, Shang M. Overexpression of phosphoserine aminotransferase 1 (PSAT1) predicts poor prognosis and associates with tumor progression in human esophageal squamous cell carcinoma. Cell Physiol Biochem. 2016;39(1):395–406.

Article  CAS  PubMed  Google Scholar 

Hart CE, Race V, Achouri Y, Wiame E, Sharrard M, Olpin SE, Watkinson J, Bonham JR, Jaeken J, Matthijs G, et al. Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway. Am J Hum Genet. 2007;80(5):931–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao R, Lopez-de-Ullibarri I. ROC curves for the statistical analysis of microarray data. Methods Mol Biol. 2019;1986:245–53.

Article  CAS  PubMed  Google Scholar 

Zhang D, Hu J, Liu Z, Wu H, Cheng H, Li C. Prognostic nomogram in patients with epithelioid sarcoma: a SEER-based study. Cancer Med. 2023;12(3):3079–88.

Article  PubMed  Google Scholar 

Rossi SH, Klatte T, Usher-Smith J, Stewart GD. Epidemiology and screening for renal cancer. World J Urol. 2018;36(9):1341–53.

Article  PubMed  PubMed Central  Google Scholar 

Motzer RJ, McDermott DF, Escudier B, Burotto M, Choueiri TK, Hammers HJ, Barthelemy P, Plimack ER, Porta C, George S, et al. Conditional survival and long-term efficacy with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma. Cancer. 2022;128(11):2085–97.

Article  CAS  PubMed  Google Scholar 

Roldan FL, Izquierdo L, Ingelmo-Torres M, Lozano JJ, Carrasco R, Cunado A, Reig O, Mengual L, Alcaraz A. Prognostic gene expression-based signature in clear-cell renal cell carcinoma. Cancers (Basel). 2022;14(15):3754.

Article  CAS  PubMed  Google Scholar 

Klasson TD, LaGory EL, Zhao H, Huynh SK, Papandreou I, Moon EJ, Giaccia AJ. ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma. Cancer Metab. 2022;10(1):14.

Article  PubMed  PubMed Central  Google Scholar 

Delahunt B, Eble JN, Egevad L, Samaratunga H. Grading of renal cell carcinoma. Histopathology. 2019;74(1):4–17.

Article  PubMed  Google Scholar 

Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;6(7):655–63.

Article  CAS  PubMed  Google Scholar 

Lewis G, Maxwell AP. Early diagnosis improves survival in kidney cancer. Practitioner. 2012;256(1748):13–6, 12.

PubMed  Google Scholar 

Bindayi A, Hamilton ZA, McDonald ML, Yim K, Millard F, McKay RR, Campbell SC, Rini BI, Derweesh IH. Neoadjuvant therapy for localized and locally advanced renal cell carcinoma. Urol Oncol. 2018;36(1):31–7.

Article  CAS  PubMed  Google Scholar 

Wood CG, Ferguson JE 3rd, Parker JS, Moore DT, Whisenant JG, Maygarden SJ, Wallen EM, Kim WY, Milowsky MI, Beckermann KE, et al. Neoadjuvant pazopanib and molecular analysis of tissue response in renal cell carcinoma. JCI Insight. 2020;5(22):e132852.

Article  PubMed  PubMed Central  Google Scholar 

Zhu X, Ma X, Wu C. A methylomics-correlated nomogram predicts the recurrence free survival risk of kidney renal clear cell carcinoma. Math Biosci Eng. 2021;18(6):8559–76.

Article  PubMed  Google Scholar 

Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, et al. Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis. Cell. 2013;152(3):599–611.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vie N, Copois V, Bascoul-Mollevi C, Denis V, Bec N, Robert B, Fraslon C, Conseiller E, Molina F, Larroque C, et al. Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells. Mol Cancer. 2008;7:14.

Article  PubMed  PubMed Central  Google Scholar 

Noh S, Kim DH, Jung WH, Koo JS. Expression levels of serine/glycine metabolism-related proteins in triple negative breast cancer tissues. Tumour Biol. 2014;35(5):4457–68.

Article  CAS  PubMed  Google Scholar 

Pollari S, Kakonen SM, Edgren H, Wolf M, Kohonen P, Sara H, Guise T, Nees M, Kallioniemi O. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res Treat. 2011;125(2):421–30.

Article  CAS  PubMed  Google Scholar 

Yang Y, Wu J, Cai J, He Z, Yuan J, Zhu X, Li Y, Li M, Guan H. PSAT1 regulates cyclin D1 degradation and sustains proliferation of non-small cell lung cancer cells. Int J Cancer. 2015;136(4):E39-50.

Article  CAS  PubMed  Google Scholar 

Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. 2012;148(1–2):259–72.

A